Indication: For use in the treatment of allergic rhinitis, hay fever, and allergic skin disorders
Pharmacology: Diphenylpyraline is an antihistamine that prevents, but does not reverse, responses mediated by histamine alone. Diphenylpyraline antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. Also, diphenylpyraline may exhibit anticholinergic actions (as do most of the antihistamines) and may thus provide a drying effect on the nasal mucosa.
Mechanism Of Action: Antihistamines such as diphenylpyraline used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. This reduces the effects of histamine, leading to a temporary reduction of allergy symptoms.
Absorption: Well absorbed after oral administration.
Interactions:
DrugBank: Interactions for Diphenylpyraline
Interactions for Diphenylpyraline:
This drug may interact with alcohol or other CNS depressants (may
potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other
medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used
concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may
prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).
Chemical IUPAC Name: 4-benzhydryloxy-1-methyl-piperidine
Chemical Formula: C19H23NO
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00719
CAS Registry Number: 147-20-6
Diphenylpyraline News (When available)
Study: Cockroach Allergen a Primary Contributor to Childhood ...Jan 8, 2006 About - News & Issues, Results from a nationwide study on factors that affect asthma in inner-city children show that cockroach allergen appears to worsen asthma symptoms more than ...
Carpet and Stuffed Animals Not Good for Allergen LevelsJan 10, 2006 About - News & Issues, Carpeting and stuffed animals increase cat and dog allergen levels, even in homes that don't have cats or dogs, according to research presented at the 2002 ...
Allergen Labeling Takes EffectJan 5, 2006 Food Consumer, The Food Allergen Labeling and Consumer Protection Act of 2004, or FALCPA, applies to foods labeled on or after 1 January 2006. ...
New allergen labeling to boost growing ‘free-from’ market?Jan 2, 2006 Beverage Daily, 02/01/2006 - Consumers who suffer from food allergies are set to benefit from new “plain English� allergen labeling rules, which also provide food and ...
Inamed says board OKs Allergen's $3.2 bln offerDec 15, 2005 Reuters CHICAGO, Dec 15 (Reuters) - Inamed Corp. (IMDC.O: Quote, Profile, Research) said on Thursday its board has unanimously approved ...
Food allergen labeling - FDA Guidance for food industryDec 20, 2005 Food Consumer, ...name of an ingredient may be unfamiliar to consumers and many consumers do not recognize that certain ingredients contain or are derived from a food allergen. ...
Company gears up to meet demand for allergen testing kitsDec 16, 2005 FoodProductionDaily.com, 16/12/2005 - With the implementation of EU allergen labelling regulations, more and more companies are producing testing kits to meet the demand from food ...
Food-allergen law spurs label changes, confusionDec 21, 2005 Fort Wayne Journal Gazette, The law – the Food Allergen Labeling and Consumer Protection Act – requires food labels to list in “plain language� whether they contain any of the ...
Publix Issues Key Lime Pie Allergen WarningDec 28, 2005 Business Wire (press release), 28, 2005--Publix Super Markets is issuing a voluntary allergen warning on Publix Key Lime Pie (whole, half and single serve slices), sold between Dec. ...
Inamed says board OKs Allergen's $3.2 bln offerDec 15, 2005 NewKerala.com, CHICAGO, Dec 15 : Inamed Corp. said on Thursday its board has unanimously approved Botox maker Allergan Inc.'s $3.2 billion offer ...
Inamed says board OKs Allergen's $3.2 bln offerDec 15, 2005 Webindia123, Inamed Corp. said on Thursday its board has unanimously approved Botox maker Allergan Inc.'s $3.2 billion offer in a deal that would ...
Food Allergen Labels on the WayDec 22, 2005 KLAS-TV, Most food labels in the US will require so-called plain language additions beginning in January. One of these new requirements is ...
Allergic ReactionsJan 12, 2006 TheHorse.com, The substance that enters the body and triggers an allergic reaction is called an allergen. So what happens once the allergen enters the body? ...
Law requiring better food labels could save livesJan 12, 2006 DetNews.com, The new labeling law requires manufacturers to identify the source of the food allergen in the list of ingredients, or to print "contains milk" or "contains soy ...
New law means food allergies must be notedJan 11, 2006 Pueblo Chieftain, The law - the Food Allergen Labeling and Consumer Protection Act - does allow for exemptions. Companies are expected to take this ...
Idaho Establishment Recalls Pot Roast Dinners Due To Undeclared ...Dec 12, 2005 Community Dispatch (press release) ...a Pocatello, Idaho, establishment, is voluntarily recalling approximately 325 pounds of frozen pot roast dinners due to an undeclared allergen (dried whole eggs ...
Food fads, fine print in '06Jan 11, 2006 Seattle Times, This month, newly printed labels have to say in clear, understandable language whether a product contains one of eight food-allergen groups. ...
New labeling law is big help to people with food allergiesJan 8, 2006 Winston-Salem Journal, That's because as of Jan. 1, newly printed labels have to say in clear, understandable language whether a product contains one of eight food-allergen groups. ...
Food allergies: New food-labeling requirementsJan 3, 2006 MayoClinic.com ...death. Despite your best efforts, you may not always know where you might encounter a food allergen. The ... Type of allergen. It requires ...
Altering home environment controls asthmaJan 13, 2006 Daily Times, The treatment, or study group, received home-based education, common pest extermination, allergen-proof fitted mattress and pillow coverings and a high ...
Facial Contact DermatitisJan 13, 2006 About - News & Issues, Patch testing for facial contact dermatitis may reveal an allergen that the patient or dermatologist had not previously considered because it was not ...
Products tackle indoor allergensJan 13, 2006 Pittsburgh Tribune-Review, Their mattress and pillows are protected with dust-resistant coverings. A self-cleaning whole-house electronic filter helps keep the air allergen-free. ...
Red, Itchy, Watery EyesJan 14, 2006 About - News & Issues, To remove mucous and allergen material from the eye, a simple irrigation with normal saline solution or artificial tears can be helpful to dilute the allergens ...
New law ensures allergens clearly listed on the labelJan 10, 2006 Evansville Courier & Press (subscription), The new Food Allergen Labeling and Consumer Protection Act allows grocery stores to sell off products that were labeled before Jan. ...
labels must be in plain languageJan 11, 2006 NorthJersey.com, The changes are part of the Food Allergen Labeling and Consumer Protection Act, which was signed in 2004 but went into effect on the first day of 2006. ...
At-home changes may help control asthma symptomsJan 10, 2006 Reuters.uk, Various reports have pointed to indoor allergen and pollutant levels as important contributors to the disproportionate burden of asthma carried by inner-city ...
Going nuts about ingredientsJan 10, 2006 Ferret, Said says there are a number of practical guidelines and strategies that food manufacturers can put in place to address the allergen issue. ...
Nothing to sneeze at: New labels point out allergensJan 5, 2006 OSU - The Lantern, Dayton, Ohio. As a result of the Food Allergen Labeling and Consumer Protection Act of 2004, which Congress passed on Aug. 2, 2004 ...
Food label law could help those with allergiesJan 2, 2006 Muncie Star Press, The label changes that took effect Sunday stem from passage of the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA). ...
Allergy education food for thoughtJan 4, 2006 Grand Traverse Herald, More immediate assistance for parents of children with food allergies comes by way of The Food Allergen Labeling and Consumer Protection Act (FALCPA). ...
Food labels now required to list major allergensJan 3, 2006 Newsday, The 2004 Food Allergen Labeling and Consumer Protection Act was sparked by fears that many food labels either didn't include the allergens in their listed ...
New Law Toughens Food Allergy Labeling RequirementsJan 3, 2006 NewsNet5.com, The Food Allergen Labeling and Consumer Protection Act of 2004, which took effect Sunday, requires food labels to list ingredients made from proteins derived ...
FDA requires food labels to list eight major allergensJan 5, 2006 Louisville Courier-Journal, Thanks to the Food Allergen Labeling and Consumer Protection Act of 2004, manufacturers are to start noting the presence of the eight major allergens -- milk ...
Vaccine candidate CYT005-AllQbG10 for allergic diseases shows ...Dec 14, 2005 Biotech Intelligence (press release), ...and asthma due to house dust mite allergy met its primary efficacy endpoint, defined as a median ten-fold increase in allergen tolerance upon conjunctival ...
Wrinkle fillers could face off in '06Jan 11, 2006 CNN/Money If an Allergen-Inamed deal goes through, Nachman said that Inamed could use the market clout from Allergen's Botox to grab market share for Juvederm. ...
Animal scares create demand for vegetarian ingredientsJan 13, 2006 NutraIngredients.com, Part of the motivation behind this is fluctuating shrimp supply from Asia, but the fact that it is allergen-free, vegetarian and kosher is a unique selling ...
Food labels will get a new look in the new yearJan 1, 2006 DetNews.com, Food allergen. ... The FDA is allowing companies to continue to use labels that were made before 2006 -- without allergen declarations. ...
New year brings new kind of food labelJan 2, 2006 Fort Wayne Journal Gazette, The flurry of label activity reflects several factors, from regulatory changes such as the implementation of a 2004 allergen law to food companies’ own ...
Nestle count the calories with new nutritional labellingJan 9, 2006 ConfectioneryNews.com, ...of any potential EU legislation concerning compulsory nutritional labelling in addition to current laws requiring full ingredient lists, allergen warnings and ...
Label law puts food allergens in spotlightJan 7, 2006 Palm Beach Post, That starts phasing out this month with the dawn of a new federal food labeling law: the Food Allergen Labeling and Consumer Protection Act. ...
Bellandur Lake plays villainJan 11, 2006 Times of India, ...menacingly. “Because of some allergen in the air, almost 50% population suffers from urticaria (skin allergy) or respiratory allergy. ...
New labeling rules a boon for consumers with allergiesJan 11, 2006 Amarillo.com (subscription), It's too easy.". The new Food Allergen Labeling and Consumer Protection Act allows grocery stores to sell off products that were labeled before Jan. ...
Nut and peanut allergy dietJan 10, 2006 Dominican Today, You may not even recognize an allergic reaction, depending on the severity, the age of the child, and previous exposure to the allergen. ...
Tree Pollen SeasonJan 12, 2006 About - News & Issues, ...addition to medication to get relief. It helps reduce the body's sensitivity to almost any airborne allergen. If you need to check ...
New label lawsJan 11, 2006 San Jose Mercury News, ...blood. Allergens: New labels must say in clear, understandable language whether a product contains one of eight food allergen groups. ...
New Food Labeling Laws Now in EffectJan 4, 2006 Wisconsin Ag Connection, Another food rule that went into effect on January 1 is the Food Allergen Labeling and Consumer Protection Act, which requires food processors to identify, "in ...
Chow Line: More children with peanut allergiesJan 2, 2006 North Texas e-News, To help stem that tide, in 2004 Congress passed the Food Allergen Labeling and Consumer Protection Act, which required the top eight allergens in foods to be ...
FDA to Require Food Manufacturers to List Food AllergensDec 20, 2005 WebWire (press release), As a result of the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA), manufacturers are required to identify in plain English the presence of ...
FDA: Food Labels Must List AllergensDec 21, 2005 WebMD The new labeling will become effective Jan. 1, 2006. This change came about as a result of the Food Allergen Labeling and Consumer Protection Act of 2004. ...
Why your food labels are suddenly easier to readDec 22, 2005 Savannah Morning News, The law, called the Food Allergen Labeling and Consumer Protection Act, requires labels use everyday words when explaining ingredients. ...
Other News To NoteDec 20, 2005 TMCnet ...rhinoconjunctivitis and asthma due to house dust mite allergies met its primary efficacy endpoint, a median 10-fold increase in allergen tolerance upon ...
Food firms must now list allergensDec 20, 2005 United Press International As another option, the labeling can say "contains" followed by the name of the source of the food allergen after or adjacent to the list of ingredients. ...
Fighting Food Allergies with LabelsDec 21, 2005 KCRG, Now the government is taking action, and it's starting with food labels. It's called the Food Allergen Labeling and Consumer Protection Act, or FALCPA. ...
Neogen Reports 32% Increase in Net IncomeJan 5, 2006 MSN Money Sales of food allergen testing products continued to show sustained growth. New allergen tests, new test formats, and anticipation ...
Food recallsJan 9, 2006 Boston Globe, ...because the product contains undeclared peanuts, a known allergen. The recalled 32-ounce plastic cans bear a best-by code of 110506 S1. ...
Restaurants should protect allergy sufferersDec 18, 2005 Cherry Hill Courier Post, The government has begun to address this issue. The Food Allergen Labeling and Consumer Protection Act of 2004, set to take effect Jan. ...
OTHER CHANGESDec 31, 2005 Kansas.com, The addition of trans fat is only one change being made to nutrition labels. Allergen listings will also be coming to a food package near you. ...
FDA requires food labels to read clearlyDec 31, 2005 Daily News - Galveston County, The Food Allergen Labeling and Consumer Protection Act of 2004 now requires manufacturers to identify the presence of ingredients that contain protein derived ...
Full disclosure of trans fats aids consumersJan 8, 2006 Kansas City Star, Paula Antonacci. “Up to this point, people have had to avoid whole classes of foods they thought might include an allergen.�. An ...
Food labels now alert consumers to allergensJan 2, 2006 Danbury News Times, Most labels will either use the word "contains" to describe the allergen, or put parenthesis around the food substance, for example "albium (egg).". ...
Kathryn Rem ColumnJan 4, 2006 Springfield State Journal Register, ...food-allergy-related reactions. The allergen labeling applies to foods manufactured on or after Jan. 1. Another labeling change ...
health: improved food labelingJan 7, 2006 Pioneer Press, 1, food labels must say if a product contains one of eight major food allergen groups: milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat or ...
DJ Livestock Update: US Group Seeks To Stop Canada CattleJan 9, 2006 TMCnet Hatfield Quality Meats of Hatfield, Pa., is voluntarily recalling about 464,820 pounds of beef franks because they contain an undeclared allergen (soy protein ...
Parents challenged by children's food allergiesJan 3, 2006 Greenwich Time, ...peanut allergy therapy, which would work in the same fashion as allergy shots, in which allergic people are given increasing doses of an allergen, but using a ...
Food recalls announcedJan 9, 2006 Providence Eyewitness News, Just over 52-hundred jars of Fisher Brand Deluxe Mixed Nuts have been recalled because the product contains undeclared peanuts, a known allergen. ...
Food recallsJan 9, 2006 WCAX, 5,232 jars of Fisher Brand Deluxe Mixed Nuts, distributed by John B. Sanfilippo and Son Inc., because the product contains undeclared peanuts, a known allergen ...
Neuropathy Mystery Solved. New Study proves electronic ReBuilder ...Jan 11, 2006 Emediawire (press release), ...the technology to send the patient home with a small battery operated device that will record the patient's response when he merely touches a suspected allergen ...
Peanut allergies on the riseJan 9, 2006 Beaver County Times, The Food Allergen Labeling and Consumer Protection Act requires that companies disclose the contents even if the ingredients are present only in coloring ...
Injections the answer for allergy sufferersJan 1, 2006 Daytona Beach News-Journal, The solution is composed of inhalant allergen extracts which you are allergic to, from tree, grass and weed pollens, mold spores, dust mites or animals. ...
James Le Fanu investigates some pillow ploys for runny nosesJan 9, 2006 Telegraph.co.uk, This is usually due to allergic rhinitis curable by identifying and excluding the allergen (coffee, pollen, house dust mites, etc) combined with a steroid ...
Doctors puzzled by surge in peanut allergiesJan 9, 2006 Maryville Daily Times, The drug Xolair is being examined as a way to quiet the immune system and increase the amount of allergen necessary to set off an anaphylactic reaction. ...
New law helps consumers avoid potentially fatal food allergiesJan 9, 2006 Woonsocket Call, The Food Allergen Labeling and Consumer Protection Act requires labels to identify, in plain English, the presence of milk, eggs, fish, shellfish, tree nuts ...
Beef Frank RecallJan 10, 2006 WSTM-TV, Hatfield Quality Meats, from Pennsylvania, is voluntarily recalling about 464,820 pounds of beef franks due to an undeclared allergen, soy protein. ...
Food Industry Advances In Labeling FightJan 9, 2006 Truth about Trade & Technology, Michigan and Connecticut mandate allergen warnings about preservatives such as sulfur dioxide at salad bars and other settings. ...
Maryland researchers discover allergens in alarming placesDec 22, 2005 Newstarget.com, Baltimore and colleagues previously reported two cases of life-threatening asthma episodes in patients who used nebulizers contaminated with cockroach allergen ...
The Hypereosinophilic SyndromesDec 27, 2005 Medscape (subscription) Of particular interest is the finding that inhalational exposure to an allergen may lead to an increased concentration of eosinophils in the esophagus. ...
New Ingredient Lists Make Spotting Food Allergens EasierDec 20, 2005 WSAW, A law called the Food Allergen Labeling and Consumer Protection Act goes into effect next year, so major food allergens have to be listed clearly on all ...
New Food Label LawDec 29, 2005 WCAV, Effective January 1, the Food Allergen Labeling and Consumer Protection Act states companies must label each ingredient in plain language. ...
Broadening of allergy portfolio - Start of phase IIa clinical ...Dec 14, 2005 Biotech Intelligence (press release), One part of the study is a randomized, double-blind and placebo-controlled (allergen alone) trial with 18 patients, which will assess safety, tolerability and ...
Teen dietingDec 13, 2005 Malaysia Star, ...and allergy researchers have found dust mite allergens in umbilical cord blood of some infants whose mothers were positive for the allergen, whereas none of ...
Trans Fat Food Labels Are ComingDec 30, 2005 Forbes ..."They will choose.". Choice will also be an option now under the new FDA requirement for labeling allergen content in food. Labels ...
New labels to cover trans-fat amounts, allergensJan 4, 2006 San Francisco Chronicle, The second is that the allergen labels are being phased in. Food companies aren't being forced to replace or relabel products already on store shelves. ...
Food labels soon to list allergenic ingredients in USDec 21, 2005 Xinhua, US food labels will have to list the common name of the source product of the allergen as well as the name of the specific allergen involved. ...
Custom manufacturing in pharma gains momentumJan 1, 2006 Financial Express, Piramal. NPIL is already supplying bulk formulations and eye products for companies like Allergen and Advanced Medical Optics. The ...
US tells food manufacturers to list food allergensJan 1, 2006 Thanh Nien Daily, ...from milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, or soybeans or to say "contains" followed by name of the source of the food allergen. ...
Labels must be clear on fatJan 2, 2006 Salt Lake Tribune, However, federal officials caution consumers to expect a transition period because the Food Allergen Labeling and Consumer Protection Act does not require ...
US Agency To Require Food Labels to Cite Presence of AllergensDec 21, 2005 Washington File, ...domestic and imported foods sold in the United States will have to state clearly in English if a food product contains an ingredient considered a food allergen ...
Most users at one timeDec 13, 2005 sportnetwork.net, In the Ray Nedin West Wales Junior Cup, Village have been handed a home tie against Carmarthenshire Junior League side Dafen Welfare, who enjoyed a 7-0 win at ...
GUAM: Ice Epidemic Sweeps Guam16 Jan 2006 Pacific Magazine, Pacific Daily News reports that since November, Guam Customs and Quarantine has seized more than $2 million worth of methamphetamine hydrochloride, the drug ...
Truck overturns, spills hydrochlorideDec 16, 2005 Montgomery Advertiser, DAPHNE -- Some Daphne businesses near the Interstate 10 exit were evacuated temporarily Thursday after a truck overturned, spilling hydrochloride. ...
PLIVA Announces Tentative Approval for Sertraline Hydrochloride ...Dec 23, 2005 Biotech Intelligence (press release), Food and Drug Administration ("FDA") has granted tentative approval for its Abbreviated New Drug Application ("ANDA") for Sertraline Hydrochloride tablets, 25 ...
Black-market bird flu drug seized in raidsJan 14, 2006 The Sunday Times, One British firm was last week offering on its website a cheaper, less effective antiviral drug called Amantadine Hydrochloride and calling it Tamiflu. ...
2 Maranaos face drug transport rapJan 13, 2006 Sun.Star, ...shabu. The materials taken from the suspects were tested positive for Methamphetamine Hydrochloride or commonly known as shabu. ...
Aricept (donepezil Hydrochloride), Orodispersible Tablet ...Dec 29, 2005 Medical News Today (press release), Tokyo, Japan, (JCN Newswire) - Eisai Co., Ltd (TSE: 4523) announced that its UK subsidiary, Eisai Ltd, has received notification of the completion of the ...
Seized jeans impregnated with cocaineJan 13, 2006 Irish Medical News, ...was detained at Dublin airport on suspicion of smuggling illegal substances, and was later found to have been carrying around 865g of cocaine hydrochloride. ...
Do the math: Same drugs, lower priceJan 15, 2006 Boston Globe, For example, Metformin hydrochloride, a diabetes drug, cost $18 at Johnson compared with $88.19 at Walgreens and $85.59 at CVS at the same quantity and ...
Genzyme Reports 22 Percent Increase in Fourth-Quarter RevenueJan 9, 2006 MSN Money Fourth-quarter revenue for Renagel(R) (sevelamer hydrochloride), a phosphate binder for patients with end-stage kidney disease on hemodialysis, grew 12 percent ...
Sepracor Receives Notice of Second Abbreviated New Drug ...Jan 12, 2006 Business Wire (press release), FDA) has received an abbreviated new drug application (ANDA) from Dey, LP for a generic version of levalbuterol hydrochloride inhalation solution. ...
McDermott´s 2005 Top 10 Life Science DecisionsJan 10, 2006 Mondaq News Alerts, ...to the Hatch-Waxman Amendments to the Federal Food, Drug and Cosmetic Act, seeking approval to market its generic version of the drug sertraline hydrochloride. ...
Sepracor to defend XopenexJan 12, 2006 MetroWest Daily News, ...maker Merck KGaA, had filed a generic drug application with the Food and Drug Administration for a version of inhalable levalbuterol hydrochloride, the active ...
Cops, NBI raid idle ‘shabu lab’Jan 13, 2006 Sun.Star, ...an empty warehouse in Barangay Pulpogan, Consolacion, Cebu were equipment units essential to the manufacture of methamphetamine hydrochloride, commonly known ...
Local newsJan 10, 2006 Pacific Daily News, In a plea agreement, Cole pleaded guilty to conspiracy to distribute more than 92 grams of methamphetamine hydrochloride from Mexico to California to Hawaii to ...
City Councilman resignsJan 12, 2006 Myrtle Beach Sun News, ...and July 5. Those drugs included hydrocodone, marijuana, OxyContin, Zyrtec 10, buspirone hydrochloride and ranitidine. He also is ...
Sepracor Receives Notice of Second Abbreviated New Drug ...Jan 12, 2006 Finanzen.net, Administration (FDA) hasreceived an abbreviated new drug application (ANDA) from Dey, LP fora generic version of levalbuterol hydrochloride inhalation solution ...
Protein Design Labs Becomes PDL BioPharmaJan 9, 2006 MSN Money The company now markets Cardene(R) IV (nicardipine hydrochloride) for short-term treatment of hypertension when oral therapy is not feasible or desirable ...
Speaking the truth on prostitutionJan 11, 2006 Taipei Times, ...do to me unless I was high," she said of her days as a sex worker, when she masked her pain through marijuana and methamphetamine hydrochloride, a stimulant ...
