Indication: For as adjunctive therapy in the management of diarrhea
Pharmacology: Diphenoxylate, an antidiarrheal, is effective as adjunctive therapy in the management of diarrhea. Diphenoxylate is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood.
Mechanism Of Action: Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa.
Drug Category: Narcotics; Antidiarrheals; Antiperistaltic; ATC:A07DA01
Interactions:
DrugBank: Interactions for Diphenoxylate
Interactions for Diphenoxylate:
Known drug interactions include barbiturates, tranquilizers, and alcohol. Diphenoxylate HCl and atropine sulfate
may interact with MAO inhibitors
In studies with male rats, diphenoxylate hydrochloride was found to inhibit the hepatic microsomal enzyme system
at a dose of 2 mg/kg/day.
Therefore, diphenoxylate has the potential to prolong the biological half-lives of drugs for which the rate of
elimination is dependent on the microsomal drug metabolizing enzyme system.
Chemical IUPAC Name: ethyl 1-(3-cyano-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate
Prescribed drug addiction on riseJan 1, 2006 Ludhiana Newsline, Many people are into high addiction of lomotil, a medicine administered while someone suffers from diarrhoea. ‘‘We have been ...
Wortham: Club sicker than dogsDec 21, 2005 Bryan College Station Eagle, ...door. "Get some Peptol Bismol or Lomotil!" Doc shouted just before the door closed behind him. "Upset stomach," Doc answered. "We ...
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