|
Dihydroergotamine
resources
|
|
|
|
|
|
DRUG INFO
Dihydroergotamine
Drug Name:
Dihydroergotamine
Indication: For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
Pharmacology: Dihydroergotamine is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. Dihydroergotamine binds with high affinity to 5-HT1Da and 5-HT1Db receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors, noradrenaline a2A, a2B and a receptors, and dopamine D2L and D3 receptors. The therapeutic activity of Dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors.
Mechanism Of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
Drug Category: Analgesics; Vasoconstrictor Agents; Sympatholytics; ATC:N02CA01
Brand Names/Synonyms: Ergotamine, 9,10-dihydro-; Dihydroergotaminum [INN-Latin]; Dihidroergotamina [INN-Spanish]; D.H.E.; D.H.E. 45; Agit; Angionorm; D.H.E. 45; DET MS; DHE-45; Dergotamine; Diergo; Dihydergot; Dihydroergotamine; Dihydroergotamine mesylate; Dihydroergotamine methanesulfonate; Dihydroergotamine monomethanesulfonate; Dirgotarl; Endophleban; Ergomimet; Ergont; Ergotonin; Ikaran; Migranal; Morena; Orstanorm; Tonopres; Verladyn
Dosage Forms: LIQUID
Absorption: Interpatient variable and may be dependent on the administration technique
Interactions: Interactions for Dihydroergotamine:
Vasoconstrictors: D.H.E. 45 (dihydroergotamine mesylate) injection, USP should not be used with peripheral vasoconstrictors because the combination may cause synergistic elevation of blood pressure.
Sumatriptan: Sumatriptan has been reported to cause coronary artery vasospasm, and its effect could be additive with D.H.E. 45 (dihydroergotamine mesylate) injection, USP. Sumatriptan and D.H.E. 45 (dihydroergotamine mesylate) injection, USP should not be taken within 24 hours of each other.
Beta Blockers: Although the results of a clinical study did not indicate a safe problem associated with the administration of D.H.E. 45 (dihydroergotamine mesylate) injection, USP to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine.
Nicotine: Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy.
Macrolide Antibiotics (e. g. erythromycin and troleandomycin): Agents of the ergot alkaloid class, of which D.H.E. 45 (dihydroergotamine mesylate) injection, USP is a member, have been shown to interact with antibiotics of the macrolide class, resulting in increased plasma levels of unchanged alkaloids and peripheral vasoconstriction. Vasospastic reactions have been reported with therapeutic doses of ergotamine-containing drugs when co-administered with these antibiotics.
SSRI's: Weakness hyperreflexia, and incoordination have been reported rarely when 5-HT1 agonists have been co-administered with SSRI's (e.g. fluoxetine, fluvoxamine, paroxetine, sertraline). There have been no reported cases from spontaneous reports of drug interaction between SSRI's and D.H.E. 45 (dihydroergotamine mesylate) injection, USP.
Oral Contraceptives: The effect of oral contraceptives on the pharmacokinetics of D.H.E. 45 (dihydroergotamine mesylate) injection, USP has not been studied.
Chemical IUPAC Name: Not Available
Chemical Formula: C33H37N5O5
Half Life: 9 hours
Drug Type: Approved Drug
# Accession No: APRD00476
CAS Registry Number: 6190-39-2
|
|
|
|
|
|
Dihydroergotamine News
(When available)
Poor, poor winners! Jan 14, 2006
INQ7.net, ...might have been bypassed in favor of Reyes. That is silly agit-prop at best. This most political of political directors seems to ...
Saturday's films in the spotlight Jan 14, 2006
The Desert Sun, Scorecard: 7. In its often-brutal melodrama, "Barrio Cuba" recalls Mikhail Kalatozov's 1964 agit-prop masterpiece, "I Am Cuba," though it thankfully refrains ...
Squaring the circle Jan 12, 2006
St.Petersburg Times.ru, ...such as Altman, Ivan Puni, Vladimir Lebedev, Alexander Samokhvalov and Kuzma Petrov-Vodkin — were attracted to the porcelain factory to produce agit-prop art ...
Conservative Negative Ads Misleading Canadians Jan 4, 2006
Liberal Party of Canada (press release), It’s an established fact – I accept it. LE COMMISSAIRE: Je pense que vous avez établi le fait que le Parti libéral agit en toute légalité. ...
2005’s best outsider and experimental music Jan 4, 2006
LA Weekly, Choubi Choubi! Folk & Pop Sounds From Iraq and Radio Pyongyang: Commie Funk & Agit Pop plus eight other essential titles. (SCG’s ...
GW, l’homme qui n’abandonne jamais Jan 4, 2006
de defensa, ...controversée. Il s’agit de l’amendement McCain sur la torture (amendement à la loi budgétaire 2007 du Pentagone). Lancé ...
La NSA après la CIA Dec 25, 2005
de defensa, Agency). Il s’agit de l’effet sur le moral du personnel de l’Agence, sur son statut, sur la légalité de son action. Cet ...
Unserious Syriana Dec 15, 2005
Town Hall, On the panel, he claimed he had no political agenda and hates “agit-prop� posing as art. He has spent quite a bit of time traveling in the Middle East. ...
ROCKING AROUND THE CHRISTMAS TREE Dec 23, 2005
Mirror.co.uk, Meanwhile, anyone who missed the summer stadium spectaculars by Dublin's favourite sons U2 might like to tune into Bono and co in full agit-rock flight on U2 ...
Hopeless Hollywood Dec 16, 2005
Evansville Courier & Press (subscription), ...the Michael Moore mold. On the panel, he claimed he had no political agenda and hates "agit-prop" posing as art. He lauded Paul ...
Of Human Bondage Dec 22, 2005
Hartford Advocate, The agit-prop, sporadically published student paper, which was founded in 1996, featured writers and editors who went on to appear in publications such as the ...
ODDBALLS AND EVENTS Dec 20, 2005
Seattle Weekly, Based on a cult novel by Sam Greenlee, Spook earns no points for subtlety, but it's an interesting agit-prop companion to Sweet Sweetback's Baad Asssss Song. ...
Film Shorts Dec 15, 2005
TheStranger.com, Apocalyptic, much? This agit-doc tells us why buying Christmas presents brings environmental doom to our doorsteps. Keystone Church, Fri Dec 16 at 7 pm. ...
Face To Face & Inquisition Dec 27, 2005
A.V. Club Face To Face played the bigger rock clubs during its brief run of success, Virginia hardcore quartet Inquisition spent those same years dispensing agit-prop to ...
T-shirt statements Dec 29, 2005
Sur, Remember, “Make Love Not War,� and “I’m the Greatest - Signed Mohammed Ali,� not very effective as agit-prop but we needed banality in those frenetic ...
'Syriana' misses the point Dec 17, 2005
Ocala.com, ...immensely consequential issue. On the panel, he claimed he had no political agenda and hates ‘‘agit-prop’’ posing as art. He has ...
GRISWOLD'S Disastrous Leadership...20 ECUSA bishops say Crisis ... Dec 13, 2005
Virtue Online, One can now add Scotland, Wales, and Ireland succumbing to the charms of gay agit-prop, and now you know why Nigerian Primate Peter Akinola and the majority of ...
Boom with a view Dec 13, 2005
hotpress.com (subscription), ...back. “I’m not trying to preach, ‘yknow,� she says of her agit-prop lyrics. “I just talk about the world the way I see it. ...
The price of fun Dec 12, 2005
Stuff.co.nz, This somehow involves 1960s beach babes, rockers and lifesavers. Yes, political theatre has arrived in theme park world. Agit-prop on aqua. ...
Thank You and Farewell to Dr. WG Speed, III Dec 15, 2005
About - News & Issues, In the 1960's, Dr. Speed was a key researcher in proving inhaled ergotamine such as Migranal Nasal Spray to be an effective treatment. ...
|
|
|
