Indication: For the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain;Diverticulitis
Pharmacology: Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Mechanism Of Action: Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Drug Category: Anticholinergic Agents; Antispasmodics; Antimuscarinics; Antispasmodics; ATC:A03BA
Interactions:
DrugBank: Interactions for Dicyclomine
Interactions for Dicyclomine:
The following agents may increase certain actions or side effects of anticholinergic drugs. amantadine
antiarrhythmic agents of class (e.g. quinidine), antihistamines antipsychotic agents (e.g. phenothiazines),
benzodiazepines. MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic
agents, tricyclic antidepressants, and other drugs having anticholinergic activity.
Anticholinergics antagonize the effects of antiglaucoma agents. Anticholinergic drugs in the presence of increased
intraocular pressure may be hazardous when taken concurrently with agents such as corti costeroids..
Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage
forms of digoxin; increased serum digoxin concentrations may result.
Anticholinergic drugs may antagonize the effects of the drugs that alter gastrointestinal motility, such as
metoclopramide. Because antacids may interfere with the absorption of anticholinergic agents, simultaneous use of
these drugs should be avoided.
The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents
used to treat achlorhydria and those used to test gastric secretion.
Chemical IUPAC Name: 2-diethylaminoethyl1-cyclohexylcyclohexane-1-carboxylate
Chemical Formula: C19H35NO2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00113
CAS Registry Number: 77-19-0
Dicyclomine News (When available)
Lannett president named CEOJan 3, 2006 philly.com, Lannett makes generic versions of the epilepsy medicine Mysoline, migraine headache treatment Fiorinal, and Bentyl for irritable bowel syndrome.
Business news in briefJan 4, 2006 Philadelphia Inquirer, Lannett, which has 180 employees, makes generic versions of the epilepsy medicine Mysoline, migraine headache treatment Fiorinal, and Bentyl for irritable ...
GUAM: Ice Epidemic Sweeps Guam16 Jan 2006 Pacific Magazine, Pacific Daily News reports that since November, Guam Customs and Quarantine has seized more than $2 million worth of methamphetamine hydrochloride, the drug ...
Truck overturns, spills hydrochlorideDec 16, 2005 Montgomery Advertiser, DAPHNE -- Some Daphne businesses near the Interstate 10 exit were evacuated temporarily Thursday after a truck overturned, spilling hydrochloride. ...
PLIVA Announces Tentative Approval for Sertraline Hydrochloride ...Dec 23, 2005 Biotech Intelligence (press release), Food and Drug Administration ("FDA") has granted tentative approval for its Abbreviated New Drug Application ("ANDA") for Sertraline Hydrochloride tablets, 25 ...
Black-market bird flu drug seized in raidsJan 14, 2006 The Sunday Times, One British firm was last week offering on its website a cheaper, less effective antiviral drug called Amantadine Hydrochloride and calling it Tamiflu. ...
2 Maranaos face drug transport rapJan 13, 2006 Sun.Star, ...shabu. The materials taken from the suspects were tested positive for Methamphetamine Hydrochloride or commonly known as shabu. ...
Aricept (donepezil Hydrochloride), Orodispersible Tablet ...Dec 29, 2005 Medical News Today (press release), Tokyo, Japan, (JCN Newswire) - Eisai Co., Ltd (TSE: 4523) announced that its UK subsidiary, Eisai Ltd, has received notification of the completion of the ...
Seized jeans impregnated with cocaineJan 13, 2006 Irish Medical News, ...was detained at Dublin airport on suspicion of smuggling illegal substances, and was later found to have been carrying around 865g of cocaine hydrochloride. ...
Do the math: Same drugs, lower priceJan 15, 2006 Boston Globe, For example, Metformin hydrochloride, a diabetes drug, cost $18 at Johnson compared with $88.19 at Walgreens and $85.59 at CVS at the same quantity and ...
Genzyme Reports 22 Percent Increase in Fourth-Quarter RevenueJan 9, 2006 MSN Money Fourth-quarter revenue for Renagel(R) (sevelamer hydrochloride), a phosphate binder for patients with end-stage kidney disease on hemodialysis, grew 12 percent ...
Sepracor Receives Notice of Second Abbreviated New Drug ...Jan 12, 2006 Business Wire (press release), FDA) has received an abbreviated new drug application (ANDA) from Dey, LP for a generic version of levalbuterol hydrochloride inhalation solution. ...
McDermott´s 2005 Top 10 Life Science DecisionsJan 10, 2006 Mondaq News Alerts, ...to the Hatch-Waxman Amendments to the Federal Food, Drug and Cosmetic Act, seeking approval to market its generic version of the drug sertraline hydrochloride. ...
Sepracor to defend XopenexJan 12, 2006 MetroWest Daily News, ...maker Merck KGaA, had filed a generic drug application with the Food and Drug Administration for a version of inhalable levalbuterol hydrochloride, the active ...
Cops, NBI raid idle ‘shabu lab’Jan 13, 2006 Sun.Star, ...an empty warehouse in Barangay Pulpogan, Consolacion, Cebu were equipment units essential to the manufacture of methamphetamine hydrochloride, commonly known ...
Local newsJan 10, 2006 Pacific Daily News, In a plea agreement, Cole pleaded guilty to conspiracy to distribute more than 92 grams of methamphetamine hydrochloride from Mexico to California to Hawaii to ...
City Councilman resignsJan 12, 2006 Myrtle Beach Sun News, ...and July 5. Those drugs included hydrocodone, marijuana, OxyContin, Zyrtec 10, buspirone hydrochloride and ranitidine. He also is ...
Sepracor Receives Notice of Second Abbreviated New Drug ...Jan 12, 2006 Finanzen.net, Administration (FDA) hasreceived an abbreviated new drug application (ANDA) from Dey, LP fora generic version of levalbuterol hydrochloride inhalation solution ...
Protein Design Labs Becomes PDL BioPharmaJan 9, 2006 MSN Money The company now markets Cardene(R) IV (nicardipine hydrochloride) for short-term treatment of hypertension when oral therapy is not feasible or desirable ...
Speaking the truth on prostitutionJan 11, 2006 Taipei Times, ...do to me unless I was high," she said of her days as a sex worker, when she masked her pain through marijuana and methamphetamine hydrochloride, a stimulant ...
City police plans to clamp down on 'date rape' drugsJan 10, 2006 Economic Times, The drugs — lorezapam, ketamine hydrochloride, alprazolam, gamma hydroxybutyric acid and flunitrazepam — are essentially sleeping pills or tranquilizers. ...
CTMA OKs supplier switchJan 12, 2006 Daily American Online (subscription), Chemstream, owned by Mike Kaufman of Boswell, will now provide the plant with sodium hydrochloride (chlorine) and phosphate, replacing SAL Chemical Co. ...
Customs officer recounts raid at hearing in ice caseJan 9, 2006 Pacific Daily News, ...afternoon as attorneys grilled Guam Customs and Quarantine officers about the raid of a hotel room allegedly being used to produce methamphetamine hydrochloride ...
Simply FitJan 12, 2006 Mercury-Register, ...after a meal. This formula contains betaine hydrochloride which starts the first phase of digestion in the stomach. It also provides ...
New hope for smokersDec 23, 2005 USA Weekend ...up. And there are non-nicotine methods, including behavior modification and the prescription drug bupropion hydrochloride (Zyban). ...
GENZYME: Pipeline HighlightsJan 12, 2006 Webbolt Business News (subscription), Enrollment has been completed in a trial evaluating the product's equivalence to sevelamer hydrochloride for patients with end-stage renal disease. ...
2100 units but no ‘checks’Jan 5, 2006 Hindustan Times, Ayurvedic officials received another complain that ephedrine hydrochloride was being mixed in ‘Som churn’ again the officials prefer to look the other way. ...
Date rape drugs available freelyJan 1, 2006 Times of India, There are at least three date rape drugs known internationally—GHB (gamma hydroxybutyric acid), Rohypnol (flunitrazepam) and Ketamine (ketamine hydrochloride ...
Company Says FDA Has OK'd its Sodium Treatment DrugDec 31, 2005 HealthCentral.com Astellas Pharma US Inc. said it would sell the drug, conivaptan hydrochloride, under the brand name Vaprisol, the Associated Press said. ...
Depomed Announces Positive Results of Phase II Clinical Trial for ...Jan 4, 2006 PharmaLive.com (press release), Proquin(R) XR (ciprofloxacin hydrochloride) once daily, extended-release tablets have been approved by the FDA for the treatment of uncomplicated urinary tract ...
Trader gets life for selling shabuJan 3, 2006 The Mindanao Daily Mirror, A 24-year-old compact disc vendor was sentenced to life imprisonment for selling eight small sachets of shabu (methamphe-tamine hydrochloride) at a pool resort ...
Amicus Therapeutics to Present at JPMorgan Healthcare ConferenceJan 4, 2006 PR Newswire (press release), The company's lead compound Amigal(TM) (migalastat hydrochloride) is in Phase ll clinical trials for Fabry disease and the company plans to initiate clinical ...
Evidence questioned in ice caseJan 5, 2006 Pacific Daily News, Justin Keith Guerrero and Renea Dorleen Cruz-Taitano, who were arrested on charges of possession of methamphetamine hydrochloride as part of the September ice ...
Major new medication promising for black heart patientsJan 2, 2006 Fort Lauderdale Sun Sentinel, The two drugs -- hydralazine hydrochloride and isosorbide dinitrate -- increase nitric oxide that relaxes and dilates blood vessels to improve blood flow. ...
Advisory - Health Canada advises consumers not to use Kaizen ...Dec 28, 2005 Canada NewsWire (press release), Kaizen Ephedrine HCL tablets contain ephedrine hydrochloride, which is authorized by Health Canada only for use as a nasal decongestant in over-the- counter ...
Pharmacogenomic Test Predicts Chemo Toxicity 1/5/06Jan 5, 2006 Bioscience Technology, ...test that identifies individuals at high risk of adverse reactions to the colon cancer chemotherapy drug irinotecan hydrochloride (Camptosar) is now being ...
Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Final ...Dec 19, 2005 PR Newswire (press release), Drug Administration (FDA) have granted final approval for the Company's Abbreviated New Drug Application (ANDA) for Tramadol Hydrochloride with Acetaminophen ...
OxyContin(R) Dismissals and Withdrawals Exceed 400Jan 5, 2006 Yahoo! News (press release) OxyContin Tablets are a controlled-release oral formulation of oxycodone hydrochloride indicated for the management of moderate to severe pain when a continuous ...
Amicus Therapeutics Appoints David J. Lockhart Chief Scientific ...Jan 6, 2006 Yahoo! News (press release) The company's lead compound Amigal(TM) (migalastat hydrochloride) is in Phase II clinical trials for Fabry disease and the company plans to initiate clinical ...
Health in 2005: the Efforts, the ResultsJan 6, 2006 AllAfrica.com, During the conference, it was said a new drug, chlorproguannil hydrochloride-clapsone-artesunate, CDA, had been discovered to be an effective cure for ...
Two indicted for "ice" distributionJan 4, 2006 KUAM.com, Wednesday. Pauline Marie Castro and John Junior Cruz were charged with distribution of methampethamine hydrochloride. According ...
Ukraine river contaminated with chlorineDec 22, 2005 ITAR-TASS, ...mountainous Sivka River, a tributary of the Dniester River in the Ivano-Frankovsk region, has been contaminated with calcium hydrochloride, substance identical ...
Moldova says no warning from Ukraine over river contaminationDec 22, 2005 ITAR-TASS, Moldova about the contamination of Ukraine’s mountainous Sivka River, a tributary of the Dniester River, with calcium hydrochloride, substance identical to ...
Antibiotic approved for honeybee diseaseJan 6, 2006 Capital Press (subscription), Before tylosin tartrate, only one other antibiotic, oxytetracycline hydrochloride (Terramycin), was available for use against American foulbrood. ...
Data Show Cost-Effectiveness of NitroMed's BiDil Through Reduced ...Dec 13, 2005 PharmaLive.com (press release), ...with Heart Failure" published today in Circulation: Journal of the American Heart Association, BiDil(R) (isosorbide dinitrate/hydralazine hydrochloride) is a ...
Aurobindo’s drug gets final nod from USFDADec 14, 2005 Daily News & Analysis, With this approval, coupled with the earlier tentative nod for its Sertraline Hydrochloride, dubbed as the bio-equivalent of Pfizer’s anti-depressant Zoloft ...
Targacept and AstraZeneca Announce Global License and Research ...Dec 31, 2005 Drug Newswire (press release), Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, including ...
FDA Approves Astellas' Vaprisol® For Treatment Of Euvolemic ...Jan 1, 2006 Medical News Today (press release), ...that the US Food and Drug Administration (FDA) has approved VAPRISOL® (investigational name: YM087, generic name: conivaptan hydrochloride injection), an ...
State to seize 'drug farm'Dec 22, 2005 News24, Nkosi said there was sufficient ephedrine hydrochloride, synthesized product and "tik" crystals on the farm premises to produce approximately 45 kg of "tik ...
Company says FDA OKs sodium level drugDec 30, 2005 Seattle Post Intelligencer ...manufacturer said Friday. Astellas Pharma US Inc. said it would market the drug, conivaptan hydrochloride, as Vaprisol. It will be ...
DRL gets tentative US nod for antidepressanDec 29, 2005 Sify, ...on Thursday received tentative approval from the US Food and Drug Administration for antidepressant drug sertraline hydrochloride. |Read more Finance news.|. ...
Sensex gains 41 pts @ 10:50 hrsDec 29, 2005 Sify, ...cent to Rs 965.90 after it received on Thursday tentative approval from the US Food and Drug Administration for anti-depressant drug sertraline hydrochloride. ...
Indian shares climb, Colombo also upDec 30, 2005 Daily Times, ...percent to Rs 978.50 after it received on Thursday tentative approval from the US Food and Drug Administration for anti-depressant drug sertraline hydrochloride ...
FDA OKs Caraco generic brand of UltracetDec 19, 2005 BusinessWeek ...less. The therapy combines a product called tramadol hydrochloride with acetaminophen, also known by its Tylenol brand name. Caraco ...
'Tik' farm seizedDec 22, 2005 News24, Nkosi said at the time there was enough ephedrine hydrochloride on the premises to produce approximately 45kg of "tik" with a value of R11.3m. ...
Dr Reddy's gets tentative nod for antidepressantDec 30, 2005 Economic Times, ...on Thursday received tentative approval from the US Food and Drug Administration for antidepressant drug sertraline hydrochloride. ...
Metro/State business briefsDec 20, 2005 DetNews.com, Monday that the US Food and Drug Administration has granted final approval for the company's new drug application for Tramadol Hydrochloride with Acetaminophen ...
Targacept, AstraZeneca Enter TC-1734 Deal For Up To $300MDec 28, 2005 BioWorld Online (subscription), Targacept has one marketed product, Inversine (mecamylamine hydrochloride), which was acquired from Sunnyvale, Calif.-based Layton Bioscience Inc. ...
Bio-IT BriefsDec 22, 2005 Bio-IT World, ...its laboratory to determine through genetic screening which patients are likely to have a serious adverse reaction to irinotecan hydrochloride (Camptosar), a ...
State to Confiscate 'Tik' FarmDec 22, 2005 AllAfrica.com, Mr Nkosi said there was sufficient ephedrine hydrochloride, synthesized product and "tik" crystals on the premises to produce approximately 45kg of "tik" with ...
Depomed, Biovail Revise Partnership Agreement for Development ...Dec 13, 2005 CCNMatthews (press release), ...agreement for the development and commercialization of Glumetza(tm), a once-daily, extended-release formulation of metformin hydrochloride (HCl) for the ...
BioCryst Initiates Intravenous Phase I/II Clinical Trial of ...Dec 22, 2005 PR Newswire (press release), ...(NASDAQ: BCRX) today announced that it has initiated a Phase I/II clinical trial of Fodosine(TM) (forodesine hydrochloride), the company's lead anti-cancer ...
America's Weight Problem - Where Is The Pharmaceutical Industry?Dec 19, 2005 Medical News Today (press release), Meridia® (sibutramine hydrochloride monohydrate) from Knoll Pharmaceuticals, one of two weight loss Rx drugs that have been approved by the Food and Drug ...
MGI PHARMA to Present at the JPMorgan Healthcare ConferenceDec 21, 2005 Genetic Engineering News, MGI PHARMA markets Aloxi(R) (palonosetron hydrochloride) injection and Gliadel(R) Wafer (polifeprosan 20 with carmustine implant) in the United States. ...
Woman gets 46 months in ice caseDec 14, 2005 Pacific Daily News, Deanna Morales was sentenced in the US District Court of Guam yesterday after pleading guilty to possession of methamphetamine hydrochloride with intent to ...
Pyrotechnics Suspended in GuatemalaDec 30, 2005 Prensa Latina, The fact shocked Guatemalans and drove different sectors to request the prohibition of the petards made of hydrochloride of potassium and fulminating mercury. ...
Termination of firefighter reversedDec 21, 2005 KUAM.com, ...reversed. John Troy Santos was charged with attempted possession with the intent to distribute methamphetamine hydrochloride. While ...
Cops bust shabu lab in Angeles CityDec 20, 2005 Sun.Star, ...scraped off from strainer funnels, drying pans, and other handling equipment by Babor's team tested positive of methamphetamine hydrochloride during an on-the ...
A combined effort to end methDec 30, 2005 Daily Home Online, ...through state and federal grants, got retailers from Wal-Mart to Dollar General involved in tracking thefts of pseudoephedrine hydrochloride, ephedrine and ...
Cephalon, Inc. Completes Acquisition of Zeneus Holdings LimitedDec 22, 2005 Yahoo! News (press release) ...company currently markets four proprietary products in the United States: PROVIGIL® (modafinil) [C-IV], GABITRIL® (tiagabine hydrochloride), ACTIQ® (oral ...
Chemicals send Disneyland workers to hospitalDec 16, 2005 OCRegister, ...the Anaheim Fire Department. The chemicals were hydrochloric acid and sodium hydrochloride, a bleach, she said. She said the result ...
Extended-Release Metformin Combo Drug Given the Green LightDec 20, 2005 Diabetes Interview, Glumetza, a once-daily extended-release formulation of metformin hydrochloride, was granted FDA approval in June 2005 for the treatment of type 2 diabetes. ...
Abelson-Taylor Wins International Award CompetitionsDec 19, 2005 PharmaLive.com (press release), ...an acne product used in the treatment of acne vulgaris, and a Sliver Award in the Dimensional Mailer Campaign for Allegra (fexofenadine hydrochloride), used to ...
Cat, cocaine and tik have firm hold on South AfricansDec 20, 2005 Mail & Guardian Online, ...in five provinces in the first six months of this year, almost one in three reported having used crack cocaine, cocaine hydrochloride, methamphetamine (tik ...
Hyperphosphatemia and Mortality: What's The ConnectionDec 27, 2005 Medscape (subscription) ...of phosphorus from the gut include aluminum hydroxide, calcium carbonate, calcium acetate, magnesium carbonate, sevelamer hydrochloride, and lanthanum carbonate ...
Irritable Bowel Syndrome (IBS)Dec 16, 2005 WSOCtv.com, ...for IBS. Alosetron hydrochloride (Lotronex®) relaxes the colon and slows the passage of waste products through the bowel. The drug ...
Facing the hard facts...Dec 21, 2005 The Kerryman, It is generally sold on the street as cocaine hydrochloride - a fine, white crystalline powder, soluble in water, known in Kerry as ‘coke’, ‘C’ and ...
Gerber: Protect your pets against insect infectionsDec 16, 2005 Mansfield News, Luckily their vet knew exactly what was causing the problem and after receiving a shot of Benadryl (diphenhydramine hydrochloride), an antihistamine, their dog ...
Two Customs officials retireDec 16, 2005 Saipan Tribune, Interior and the Australian Customs Services, has been responsible for the seizure of millions of dollars in illegal drugs such as methamphetamine hydrochloride ...
'Drug peddler' fallsDec 30, 2005 Sun.Star, Mangaliman said the suspect was collared in the act of selling suspected methamphetamine hydrochloride known as shabu, weighing some .1367 grams, to a poseur ...
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