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Dicumarol
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DRUG INFO
Dicumarol
Drug Name:
Dicumarol
Indication: For decreasing blood clotting
Pharmacology: Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It is also used in biochemical experiments as an inhibitor of reductases.
Mechanism Of Action: Dicumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
Drug Category: Uncoupling Agents; Anticoagulants; Enzyme Inhibitors; ATC:B02
Brand Names/Synonyms: Acadyl; Acavyl; Antitrombosin; BHC; Baracoumin; Bis-Hydroxycoumarin; Bishydroxycoumarin; Cuma; Cumid; Dicoumal; Dicoumarin; Dicoumarol; Dicuman; Dicumaol R; Dicumarine; Dicumarol; Dicumol; Dikumarol; Dufalone; Kumoran; Melitoxin; Temparin; Trombosan
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 2-hydroxy-3-[(2-hydroxy-4-oxo-chromen-3-yl)methyl]chromen-4-one
Chemical Formula: C19H12O6
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00761
CAS Registry Number: 66-76-2
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Dicumarol News
(When available)
Oppie collects items while traveling Jan 14, 2006
Jakarta Post, ...added. Oppie rose to fame through her song Andai (If), Cuma Khayalan (Only A Dream) and Bidadari Badung (Naughty Princess). Asiaweek ...
Egyptian Opposition Leader Sentenced to 5 yrs. Dec 24, 2005
Zaman Online, ...jail. After chief judge Adil Abdelsalem Cuma read the verdict, Nour chanted slogans “Fall with Mubarak, and Fall with regime.''. ...
ITALIAN HOSTAGES RELEASED. CIAMPI: HOPEFULLY IN ITALY TONIGHT Jan 6, 2006
Agenzia Giornalistica Italia, ...their release". THe head of state, on a private visit in Naples since New Year's day, visited the acropolis in Cuma today. (AGI) .
Deportee being sought for double murder in Tower Hill Dec 30, 2005
RJR, The victims, Donovan Bailey otherwise called Jah Love and Patrick Morrison otherwise called Cuma were playing dominoes with a group of friends when they were ...
GREAT DANE'S A SCARLET LADY Jan 14, 2006
Glasgow Sunday Mail, By Billy Sloan And Mickey Mcmonagle. DANISH singer Tina Dico is set to hit the big time with her UK debut Warm Sand. And the 27-year ...
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