Indication: For treatment and relief of symptoms of allergies, hay fever, and colds
Pharmacology: In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dexbrompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Mechanism Of Action: Dexbrompheniramine competitively binds to the histamine H1-receptor. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Absorption: Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
Interactions:
DrugBank: Interactions for Dexbrompheniramine
Interactions for Dexbrompheniramine:
Dexbrompheniramine can interact with alcohol or other CNS depressants
(may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other
medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used
concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may
prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).
Chemical IUPAC Name: 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
Spoonful of cold realityJan 10, 2006 Chicago Tribune, They include the diphenhydramine in Benadryl, the brompheniramine in Dimetapp, the chlorpheniramine in Chlor-Trimeton, and many other products by the same over ...
Cough Medicine Doesn't Work, May Harm KidsJan 9, 2006 FOX News They specifically suggest the antihistamine brompheniramine and the decongestant pseudoephedrine, both found in many over-the-counter cold remedies. ...
Don't sneeze at this: Cough remedies uselessJan 10, 2006 Globe and Mail, ...respiratory tract. Adult consumers can look on the label for active ingredients such as brompheniramine and pseudoephedrine. A number ...
ACCP: No evidence shows cough syrups work for coughsJan 10, 2006 Food Consumer, For adults, the report recommends use of older antihistamine such as brompheniramine with a decongestant such as pseudoephedrine for treatment of acute coughs ...
Chest Physicians Challenge Benefit Of Cold MedsJan 10, 2006 KDKA, The study recommends using older antihistamines like brompheniramine which is in Dimetapp and pseudophedrine in Sudafed, but not the non-drowsy antihistamines. ...
New Guidelines Suggest Most Cough Medicines Don't WorkJan 10, 2006 WISC, The new cough guidelines recommend using older antihistamines with a decongestant like Brompheniramine and Pseudoephedrine for adult coughs. ...
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