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Desoxycorticosterone Pivalate
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DRUG INFO
Desoxycorticosterone Pivalate
Drug Name:
Desoxycorticosterone Pivalate
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Indication: For treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis.
Pharmacology: Used to treat adrenocortical insufficiency, desoxycorticosterone pivalate is a mineralocorticoid hormone and an analogue of desoxycorticosterone. It primarily acts on the metabolism of sodium, potassium and water. When the drug is given, there is decreased excretion of sodium accompanied by increased excretion of potassium; the concentration of sodium in the blood is thereby increased whereas that of potassium is decreased. There is a concomitant increase in the volume of blood and extracellular fluids, with a fall in hematocrit. It increases the rate of renal tubular absorption of sodium.
Mechanism Of Action: Desoxycorticosterone Pivalate binds to the mineralocorticoid receptor. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. Desoxycorticosterone pivalate exerts its effect through its interaction with the mineralocorticoid receptor (MR), whereby it reacts with the receptor proteins to form a steroid-receptor complex. This complex moves into the nucleus, where it binds to chromatin which results in genetic transcription of cellular DNA to messenger RNA. The steroid hormones appear to induce transcription and synthesis of specific proteins, which produce the physiological effects seen after administration.
Drug Category: Diuretics; Anti-Addison Agents; ATC:H02A
Brand Names/Synonyms: BRN 3174879; Cortexone M; DOCP; DTMA; Deoxycorticosterone Pivalate; Deoxycorticosterone Trimethylacetate; Deoxycortolone Pivalate; Deoxycortone Pivalate; Deoxycortone Trimethylacetate; Desoxycorticosterone Pivalate; Desoxycorticosterone Trimethylacetate; Desoxycortone Pivalate; NSC 95278; Neodin-Depositum; Percorten; Percorten M; Percorten Pivalate
Dosage Forms: CREAM; SUSPENSION; IMPLANTATION; PELLET
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: [2-(10,13-dimethyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl]2,2-dimethylpropanoate
Chemical Formula: C26H38O4
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00709
CAS Registry Number: 808-48-0
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