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Desogestrel
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DRUG INFO
Desogestrel
Drug Name:
Desogestrel
Indication: For the prevention of pregnancy in women who elect to use this product as a method of contraception.
Pharmacology: Desogestrel is used as a female contraceptive. Desogestrel is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Desogestrel tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.
Mechanism Of Action: Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like desogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.
Drug Category: Contraceptives, Oral, Synthetic; ATC:G03AC09
Brand Names/Synonyms: Cerazette; Cyclessa; DESOGESTREL; Desogen; Desogestrel; Desogestrel [Usan:Ban:Inn]; Desogestrelum [Inn-Latin]; HSDB 3593; Kariva; Mircette; ORG 2969; Org-2969, Cerazette; Ortho-Cept
Dosage Forms: TABLET
Absorption: Following oral administration, the relative bioavailability of desogestrel compared to a solution, as measured by serum levels of etonogestrel, is approximately 100%.
Interactions:
DrugBank: Interactions for Desogestrel
Interactions for Desogestrel:
Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have
been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with
barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and
tetracyclines (72).
Chemical IUPAC Name: 13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-ol
Chemical Formula: C22H30O
Half Life: 27.8±7.2 hours
Drug Type: Approved Drug
# Accession No: APRD00762
CAS Registry Number: 54024-22-5
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Desogestrel News
(When available)
Anti-pregnancy pill making a comeback Feb 2, 2006
Desogestrel, whose main ingredient is derived from the roots of a Mexican wild yam, is targeted at the female population (48.1 percent) that, according to the ... - INQ7.net,
Ignorance, not faith, behind baby boom Feb 5, 2006
...should have informed choices and make their own decision," said Ballmer at the relaunching of the modern low-dose oral contraceptive Desogestrel 150 mcg ... - Journal Online,
Cytogen and Savient Sign Letter of Intent for Marketing of ... Feb 8, 2006
Savient's product Mircette(R) (desogestrel/ethinyl estradiol and ethinyl estradiol), an oral contraceptive, is marketed by its licensee, Duramed Pharmaceuticals ... - PR Newswire (press release),
Birth Control Pills Can Cause Blood Clots Jan 30, 2006
Third-generation pills are more likely to cause problems, because they contain desogestrel, a different kind of hormone than older pills. ... - NBC 10.com,
BARR PHARMACEUTICALS: Barr Pharmaceuticals Financial Outlook Jan 5, 2006
Webbolt Business News (subscription), Health, LLC and its ParaGard(R) IUD; (2) the potential impact of its non-binding Letter of Intent to acquire the exclusive rights to Organon's Mircette(R) oral ...
Savient Pharmaceuticals Requests Additional Extension from NASDAQ ... Jan 13, 2006
Genetic Engineering News, ...population. Savient's product Mircette(R), an oral contraceptive, is marketed by its licensee, Duramed Pharmaceuticals, Inc. Puricase ...
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