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Delavirdine
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DRUG INFO
Delavirdine
Drug Name:
Delavirdine
Indication: For the treatment of HIV-1 infection in combination with appropriate antiretroviral agents when therapy is warranted
Pharmacology: Delavirdine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Delavirdine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of Delavirdine does not compete with template or nucleoside triphosphates. HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by Delavirdine.
Mechanism Of Action: Delavirdine binds directly to viral reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by disrupting the enzyme's catalytic site.
Drug Category: Anti-HIV Agents; Nonnucleoside Reverse Transcriptase Inhibitors; ATC:J05AG02
Brand Names/Synonyms: BHAP-U 90152; Bhap Der; DLV; Delavirdine; Rescriptor; SPP
Dosage Forms: caplets
Absorption: rapidly absorbed
Interactions: Antiacid, clarithromycin, Didanosine, Fluconazole, Fluoxetine, Indanavir,
Ketoconazole, Phenytoin, Phenobarbitol, carbamazepine, Rifabutin, Rifampin,
Ritanovir, Saquinavir.
Chemical IUPAC Name: N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl]methanesulfonamide
Chemical Formula: C22H28N6O3S
Half Life: 5.8 hours
Drug Type: Approved Drug
# Accession No: APRD00149
CAS Registry Number: 136817-59-9
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Delavirdine News
(When available)
Psychiatric Manifestations of HIV Infection and AIDS Dec 5, 2005
Psychiatric Times, The other members of the NNRTI medication class, delavirdine (Rescriptor) and nevirapine (Viramune), have not been associated with significant CNS adverse ...
The 14 Worst Corporate Evildoers Jan 3, 2006
Axis of Logic, In addition to Viagra, Zoloft, Zithromax and Norvasc, Pfizer produces the HIV/AIDS-related drugs Rescriptor, Viracept and Diflucan (fluconazole). ...
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