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Chlorzoxazone
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DRUG INFO
Chlorzoxazone
Drug Name:
Chlorzoxazone
Indication: For the relief of discomfort associated with acute painful musculoskeletal conditions.
Pharmacology: Chlorzoxazone, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Chlorzoxazone is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis. Chlorzoxazone is also a centrally-acting agent for painful musculoskeletal conditions. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex a.c. involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles.
Mechanism Of Action: Chlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium influx.
Drug Category: Muscle Relaxants, Central; ATC:M03BB03
Brand Names/Synonyms: Biomioran; Chloroxazone; Chlorzoxane; Chlorzoxazon; Chlorzoxazone; EZE-DS; Escoflex; Flexazone; Mioran; Miotran; Myoflexin; Myoflexine; Neoflex; Paraflex; Parafon Forte Dsc; Pathorysin; Relaxazone; Remular; Remular-S; Solaxin; Strifon Forte Dsc; Usaf Ma-10
Dosage Forms: Tablet (500 mg)
Absorption: Not Available
Interactions: Interactions for Chlorzoxazone:
The concomitant use of alcohol or other central nervous system depressants may have an additive effect.
Chemical IUPAC Name: 5-chloro-3H-benzooxazol-2-one
Chemical Formula: C7H4ClNO2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00308
CAS Registry Number: 95-25-0
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Chlorzoxazone News
(When available)
Rogers Corp. to Showcase “Green� High Frequency Circuit ... Dec 23, 2005
PCB007 (press release), ...of the two new lines of 2L-FCCL API materials include R/flex® AP 200 material, a single-clad, cast-on type product and Mitsui Chemicals NEOFLEX™ NFX material ...
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