Indication: For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Pharmacology: Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.
Mechanism Of Action: Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism.
Drug Category: Diuretics; Antihypertensive Agents; ATC:C03BA
Absorption: Absorbed relatively rapidly after oral administration
Interactions:
DrugBank: Interactions for Chlorthalidone
Interactions for Chlorthalidone:
Chlorthalidone may add to or potentiate the action of other antihypertensive drugs. Potentiation occurs with
ganglionic peripheral adrenergic blocking drugs.
Medication such as digitalis may also influence serum electrolytes. Warning signs, irrespective of cause, are:
dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue,
hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting.
Insulin requirements in diabetic patients may be increased, decreased, or unchanged. Higher dosage of oral
hypoglycemic agents may be required. Latent diabetes mellitus may become manifest during chlorthalidone
administration.
Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.
Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine. This diminution is not
sufficient to preclude effectiveness of the pressor agent for therapeutic use.
Chemical IUPAC Name: 2-chloro-5-(1-hydroxy-3-oxo-1,2-dihydroisoindol-1-yl)-benzenesulfonamide
Clash of the Local Wrestling TitansJan 4, 2006 WBAY, In the 119-pound weight class, LC was up 28-12 when Wrightstown's Ryan Renon, who's ranked second in the state in his class, got the pin. ...
TURIN 2006: SPORT; HOCKEY, ITALIAN OLYMPIC TEAM NAMEDDec 29, 2005 ansa.it, ...squad.'' Operation Turin will start on February 3 with the preparatory training camp, which will probably take place at Altopiano del Renon (Bolzano), and the ...
Prep wrestling honor rollJan 12, 2006 Appleton Post Crescent, 119: Luke Harness, Winneconne (24-2, .923); Ryan Vosters, Freedom (18-2, .900); Ryan Renon, Wrightstown (23-4, .852); Calvin Krogwold, Appleton West (22-4, .846 ...
Wrestling honor rollJan 12, 2006 Green Bay Press Gazette, 119 — Spencer Peterson, sr., West/Southwest, 18-3; Ryan Renon, so., Wrightstown, 22-4; Kyle VanCamp, sr., Freedom, 14-4; Josh VanderMeulen, sr., Bonduel, 22-3 ...
Kenosha St. Joseph 73, Lake Geneva Badger 64Jan 8, 2006 Appleton Post Crescent, 25. 119 – First: Carson Beebe MONT dec. Shawn Perry MERR 9-3; Third: Ryan Renon WRIG pinned Jefffery Crook RV 1:19. 125 – First ...
Wrestling honor rollJan 5, 2006 Green Bay Press Gazette, ...so., New London, 9-3. 119: Ryan Renon, so., Wrightstown, 16-3; Shane Wotachek, so., Kewaunee, 9-3. 125: Josh VanderMeulen, sr., Bonduel ...
Luxemburg-Casco nips WrightstownJan 4, 2006 Appleton Post Crescent, Ben VandenWymelenberg 9-7; 119: Ryan Renon W pinned Will Stahl 1:02; 125: Chris Seidl LC pinned Cyle Schneider 6:32 (OT); 130: Bret Klopp W pinned Jeremy Treml ...
Ghosts wear Cheesehead crownJan 8, 2006 Appleton Post Crescent, ...in the tournament. The Tigers had two third-place finishers in sophomore Ryan Renon (119) and freshman Bret Klopp (130). As a result ...
Wrestling: Cibula takes title at CheeseheadJan 8, 2006 Green Bay Press Gazette, ...the finals. Wrightstown's Ryan Renon at 119 and Bret Klopp at 130 finished third, and Eric Boylan at 160 took fourth. Luxemburg-Casco's ...
Wrestling: LC holds on, takes showdownJan 4, 2006 Green Bay Press Gazette, Ben VandenWymelenberg, 9-7; 119: Ryan Renon, W, pinned Will Stahl, 1:02; 125: Chris Seidl, LC, pinned Cyle Schneider, 6:32 (OT); 130: Bret Klopp, W, pinned ...
Local standouts Rolfe and Cook victorious in their weight classesDec 17, 2005 Richmond Times Dispatch, Kurt Bloemer won the title match in the 135-pound class, and Stephen Schnurer (103) and Ryan Renon were runner ups in their weight classes to help Wrightsville ...
Wrestling: Tigers have 10 unbeatens at CheeseheadJan 7, 2006 Green Bay Press Gazette, The Tigers' Ryan Renon at 119, Cyle Schneider at 125, Bret Klopp at 130, Kurt Bloemer at 135, Kyle Kamps at 152, Eric Boylan at 160, Beau Carter at 171, Tharin ...
Wrestling: Cream rising to the topDec 22, 2005 Green Bay Press Gazette, Kurt Bloemer went 5-0 to take first in the 135-pound weight class, while Stephen Schnurer, Ryan Renon and Tharin Schussler took home second-place finishes with ...
Wrestling: Luxemburg-Casco, Wrightstown take invitationalsDec 18, 2005 Green Bay Press Gazette, ...injury. The Tigers had three other wrestlers reach the finals: Stephen Schnurer at 103, Ryan Renon at 119 and Tharin Schussler at 189. ...
BAD WEATHER: FREEZING IN ALTO ADIGE, -25 ON THE MOUNTAINSDec 30, 2005 Agenzia Giornalistica Italia, On the skiing slopes of the Plose mountain ( over Bressanone) the temperature reached -21.5, in Corno del Renon -21.5 and in Cima Undici (above Curon Venosta ...
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