Indication: For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders.
Pharmacology: Chlorprothixene is a typical antipsychotic drug of the thioxanthine class. It has a low antipsychotic potency (half to 2/3 of chlorpromazine). An intrinsic antidepressant effect of chlorprothixene has been discussed, but not proven yet. Likewise, it is unclear, if chlorprothixene has genuine analgesic effects. An antiemetic effect, as with most antipsychotics, exists. It is used in the treatment of nervous, mental, and emotional conditions. Improvement in such conditions is thought to result from the effect of the medicine on nerve pathways in specific areas of the brain. Chlorprothixene has a strong sedative activity with a high incidence of anticholinergic side-effects. Chlorprothixene is structurally related to chlorpromazine, with which it shares in principal all side effects. Allergic side-effects and liver damage seem to appear with an appreciable lower frequency.
Mechanism Of Action: Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Drug Category: Antipsychotics; Dopamine Antagonists; ATC:N05AF03
Interactions:
DrugBank: Interactions for Chlorprothixene
Interactions for Chlorprothixene:
Chlorprothixene may increase the plasma-level of concomitantly given
lithium. In order to avoid lithium intoxication, lithium plasma levels should be monitored closely. If
chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. 50%), because
chlorprothixene amplifies the therapeutic actions and side-effects of opioids massively. Avoid the concomitant use of
chlorprothixene and tramadol (Ultram). Massive seizures may be encountered with this combination. Consider additive
sedative effects and confusional states to emerge, if chlorprothixene is given with benzodiazepines or barbituates.
Choose particular low doses of these drugs. Exert particular caution in combining chlorprothixene with other
anticholinergic drugs (tricyclic antidepressants and antiparkinsonian agents): Particularly the elderly may develop
delirium, high fever, severe obstipation, even ileus and glaucoma.
Chemical IUPAC Name: 3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethyl-propan-1-amine
Chemical Formula: C18H18ClNS
Half Life: 8 to 12 hours
Drug Type: Approved Drug
# Accession No: APRD00718
CAS Registry Number: 113-59-7
Chlorprothixene News (When available)
Study briefs, 1/03: Antipsychotics, kidney disease, foot soresJan 3, 2006 Lincoln Journal Star, ...included the conventional antipsychotics Tindal, Thorazine, Prolixin, Permitil, Serentil, Trilafon, Mellaril, Stelazine, Vesprin, Taractan, Haldol, Loxitane ...
Neighborhood digest: Dec. 26Dec 26, 2005 Annapolis Capital, ...can access testing services, academic advising, registration and financial aid and can pay for classes, work on research projects at Truxal Library and buy ...
Neighborhood digest: Dec. 28Dec 28, 2005 Annapolis Capital, If students lack adequate computer access at home or work, they may use computers on the Arnold campus in the Truxal Library, at the Glen Burnie Town Center or ...
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