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Chlorpromazine
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DRUG INFO
Chlorpromazine
Drug Name:
Chlorpromazine
Indication: For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness.
Pharmacology: Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.
Mechanism Of Action: Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use).
Drug Category: Antipsychotics; Antiemetics; Dopamine Antagonists; Phenothiazines; ATC:N05AA01
Brand Names/Synonyms: Largactil; Contomin; Chlorpromados; Chlorderazin; Ampliactil; Aminazine; Aminazin; Fenactil; Fenaktyl; Chlorpromanyl-20; Chlorpromanyl-40; Chlorpromazine Hydrochloride Intensol; Largactil Liquid; Largactil Oral Drops; Novo-Chlorpromazine; Thorazine; Thorazine Spansule
Dosage Forms: DROPS; LIQUID; SOLUTION; SYRUP; TABLET
Absorption: Not Available
Interactions: Interactions for Chlorpromazine:
The concurrent use of two or more drugs with anticholinergic activity--such as an antipsychotic drug (eg, chlorpromazine), an antiparkinsonian drug (eg, trihexyphenidyl), and/or a tricyclic antidepressant (eg, amitriptyline)--commonly results in excessive anticholinergic effects, including dry mouth and associated dental complications, blurred vision, and, in patients exposed to high temperature and humidity, hyperpyrexia.
Interactions may also occur with the following: anti-depressants/anti-anxiety drugs, drugs used to treat an overactive thyroid, beta-blockers (e.g., propranolol), sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medication (e.g., codeine), drugs used to aid sleep, drowsiness-causing antihistamines (e.g., diphenhydramine), any other drugs that may make you drowsy.
Chemical IUPAC Name: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
Chemical Formula: C17H19ClN2S
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00482
CAS Registry Number: 50-53-3
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Chlorpromazine News
(When available)
Psychiatric drugs restored Nia's sanity and destroyed her beauty ... Jan 25, 2006
The older drugs like Chlorpromazine and Haloperidol were felt to be “dirtier� and to have worse side effects, including the irreversible lip-smacking and ... - Prospect Magazine,
Brief Reports: Patterns of Psychotropic Medication Use by Race ... Jan 25, 2006
First-generation antipsychotics included chlorpromazine, fluphenazine, mesoridazine, thiothixene, perphenazine, thioridazine, trifluoperazine, haloperidol ... - Psychiatric Services (subscription)
A Horrific Case of Hiccups, a Novel Treatment Jan 9, 2006
Mr. Shafer "had essentially been tried on everything," Dr. Payne said, including a major tranquilizer, chlorpromazine; a muscle relaxant, baclofen; and ... - New York Times,
The phone that can steer you away from traffic hell Jan 13, 2006
Important, too, was the new range of drugs like chlorpromazine and other anti-depressants. In 1961, attitudes to mental hospitals had irrevocably changed. ... - Leeds Today,
Extra suicide care call Jan 24, 2006
...so. He also revealed he had ingested a quantity or chlorpromazine, which had been prescribed for his partner," Mr Matterson said. ... - The Mercury,
Time to repay debt to developing nations Jan 18, 2006
The medications they use in the public service are Chlorpromazine, tricyclics, Haloperidol, diazepam, Chlordiazepoxide and lithium. ... - Irish Medical Times,
A Trip to the Far Side of Madness Jan 2, 2006
CounterPunch, ...doctors, who persuaded themselves that I was suicidal, piled into two cars, sped to my apartment, broke in, and jammed me with needles full of Largactil, a fast ...
Geoghan's killer reserves his remarks for reporters, not the jury 16 Jan 2006
Salem News, Records introduced during that trial showed he took the anti-psychotic drug Thorazine and the hyperactivity treatment Ritalin as a teenager. ...
Opening statements scheduled in case of alleged Geoghan killer Jan 10, 2006
Boston Globe, Records introduced at the trial showed he took the anti-psychotic drug Thorazine and the hyperactivity treatment Ritalin as a teenager. ...
Starring Lauren Lee Smith Jan 13, 2006
Winnipeg Free Press (subscription), ...but limited in the underwritten dramatic scenes, a problem that is exacerbated by her habit of describing her sexploits with a thorazine-drip voiceover ...
Jury Selection Begins For Man Who Killed Pedophile Priest Jan 9, 2006
All Headline News As a teen, he took the anti-psychotic drug Thorazine and Ritalin for hyperactivity. Druce also claimed to have been sexually abused as a child. ...
Kooky sitcom fails to tickle my funny bone Jan 12, 2006
Charlotte Observer, Kate and Allie" and "3rd Rock From the Sun," is left to flail around the set in a desperate effort to inject some energy into a script marinated in Thorazine. ...
Caveat conquer Dec 30, 2005
Canoe.ca, Secret in an attempt to showcase how far they’ve come since its release, thanks in part to the addition of guitarist Joe Sikorski ex of local vets Thorazine. ...
Study briefs, 1/03: Antipsychotics, kidney disease, foot sores Jan 3, 2006
Lincoln Journal Star, The drugs included the conventional antipsychotics Tindal, Thorazine, Prolixin, Permitil, Serentil, Trilafon, Mellaril, Stelazine, Vesprin, Taractan, Haldol ...
From our January issue: How one effective and largely unsung ... Dec 24, 2005
The American Prospect, ...are. He should be greeted at the door with a smile, a pat on the back, and a handful of Thorazine, and then sent on his way. What ...
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