Chlorpheniramine resources


DRUG INFO
Chlorpheniramine

Drug Name: Chlorpheniramine

Indication: For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.



Pharmacology: In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Mechanism Of Action: Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Drug Category: Anti-allergic Agents; Antipruritics; Antihistamines; ATC:R06AB02

Brand Names/Synonyms: Aller-Chlor; Allergican; Allergisan; Antagonate; Chlo-Amine; Chlor-Trimeton; Chlor-Trimeton Allergy; Chlor-Trimeton Repetabs; Chlor-Tripolon; Chlorate; Chloropheniramine; Chlorophenylpyridamin; Chlorophenylpyridamine; Chloropiril; Chloroprophenpyridamine; Chlorphenamine; Chlorpheniramine; Chlorpheniramine Maleate; Chlorprophenpyridamine; Clorfeniramina; Cloropiril; Dexchlorpheniramine; Dexchlorpheniramine Maleate; Efidac 24 Chlorpheniramine Maleate; Gen-Allerate; Haynon; Histadur; Kloromin; Mylaramine; Novo-Pheniram; Pediacare Allergy Formula; Phenetron; Piriton; Polaramine; Polaronil; Pyridamal 100; Telachlor; Teldrin

Dosage Forms: Tablet (chlorpheniramine maleate)

Absorption: Well absorbed by gastrointestinal tract

Interactions: DrugBank: Interactions for Chlorpheniramine

Interactions for Chlorpheniramine:


Substrate of CYP2D6 (minor), 3A4 (major); Inhibits CYP2D6 (weak).

Increased toxicity (CNS depression): CNS depressants, MAO inhibitors, tricyclic antidepressants, phenothiazines.

CYP3A4 inhibitors: May increase the levels/effects of chlorpheniramine. Example inhibitors include azole antifungals, ciprofloxacin, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, and verapamil.





Chemical IUPAC Name: 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine

Chemical Formula: C16H19ClN2

Half Life: 21-27 hours

Drug Type: Approved Drug

# Accession No: APRD00001

CAS Registry Number: 132-22-9



Chlorpheniramine News
(When available)



Epilepsy - UCB Receives EMEA Positive Opinion And FDA Approvable ...  Feb 5, 2006
UCB key products are Keppra® (levetiracetam), Zyrtec®* (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex), and Equasym(TM ... - Medical News Today (press release),

Sniffing? Sneezing? Think twice before medicating  Feb 3, 2006
...with a cough needs, according to Dr. Richard D. Irwin, is a first-generation antihistamine such as diphenhydramine, chlorpheniramine and brompheniramine with a ... - Lowell Sun,

New Cough Medicine Guidelines  Jan 29, 2006
For coughs tied to the common cold, consider older types of antihistamines -- such as diphenhydramine (found in Benadryl), chlorpheniramine (found in Chlor ... - Charlotte Observer,

No evidence cough syrups work, panel says  Jan 25, 2006
...telephone interview. The older-generation antihistamines that work against cough include chlorpheniramine, he said. Newer, brand ... - Daily Nation (subscription),

Need help surfing cold and flu medicines?  Feb 1, 2006
Cold and allergy remedies generally include antihistamines (such as chlorpheniramine, brompheniramine or diphenhydramine) to reduce the drips and the sneezes ... - South Bend Tribune,

No evidence cough syrups work  Jan 9, 2006
...children, he said. The older-generation antihistamines that work against cough include chlorpheniramine, he said. Newer, brand-name ... - Australian,

Doctors critical of cough syrups  Jan 10, 2006
...antihistamine with a decongestant. Antihistamines that work against cough include chlorpheniramine and diphenhydramine. "There is no ... - Seattle Times,

Spoonful of cold reality  Jan 10, 2006
They include the diphenhydramine in Benadryl, the brompheniramine in Dimetapp, the chlorpheniramine in Chlor-Trimeton, and many other products by the same over ... - Chicago Tribune,

Some Cough Medicines May Hurt, Not Help  Jan 14, 2006
...to children. The older-generation antihistamines that work against cough include chlorpheniramine, Dicpinigaitis said. Newer, brand ... - Los Angeles Times,

In The News: Next Time, Try Soup  Jan 14, 2006
Or try the older-generation antihistamine chlorpheniramine combined with the decongestant pseudoephedrine; they treat the runny nose and nasal congestion that ... - Newsweek

Panel Sees Over-the-Counter Cough Medicines as Useless  Jan 11, 2006
According to the new guidelines, older-generation OTC decongestants and antihistamines such as chlorpheniramine will work best for adults, because they stop ... - Newsinferno.com,

Children Remain Highly Vulnerable to Potentially Deadly Medication ...  Jan 13, 2006
The drugs detected were ephedrine, pseudoephedrine, dextromethorphan, diphenhydramine, chlorpheniramine, brompheniramine, ethanol, carbinoxamine, levorphanol ... - Newsinferno.com,

New guidelines say which drugs really kill a cough  Jan 19, 2006
Newer, not better. Brompheniramine, chlorpheniramine, and diphenhydramine are acceptable antihistamines for ordinary coughs. Newer ... - U.S. News & World Report

Updated Guidelines For Treating Coughs  Jan 24, 2006
...naproxen (sold under several brand names, including Aleve) or older antihistamines, such as diphenhydramine (found in Benadryl), chlorpheniramine (found in ... - Hartford Courant,

Non-prescription cough medicine won't help that cough  Jan 9, 2006
Dicpinigaitis advises the use of the older-generation antihistamines that work against coughs which include chlorpheniramine, newer, brand-name antihistamines ... - News-Medical.net, [an error occurred while processing this directive] Trainer Holloway Disqualified Over Drugs  16 Jan 2006
Virtual Form Guide, Both Holloway and Hedges denied giving the six-year-old the substance Acepromazine Maleate, commonly known as Ace, and offered that it could have been done by ...

Avandia (rosiglitazone maleate): Post-marketing Reports of New ...  Jan 5, 2006
PharmaLive.com (press release), ROCKVILLE, Md., Jan. 5, 2006--GlaxoSmithKline and FDA notified healthcare professionals about post-marketing reports of new onset ...

NSW stewards inquiry into tranquiliser find  Jan 13, 2006
ThoroughbredNews.co.nz, 1pm on Monday, 16 January 2006, following the Analyst's report of the presence of a metabolite of the veterinary tranquiliser Acepromazine Maleate being found ...

BioDelivery Sciences Retains The Investor Relations Group of New ...  Jan 13, 2006
Genetic Engineering News, As previously announced, BDSI submitted a New Drug Application (NDA) on Emezine(R), a dissolving buccal tablet formulation of prochlorperazine maleate for the ...

NPPA FIXES/REVISES THE PRICES OF BULK DRUGS AND FORMULATIONS  Dec 27, 2005
Press Information Bureau (press release), Bulk Drugs – The prices of bulk drugs Sodium Penicillin G, Procaine Penicillin G, Benzathine Penicillin G, Phenramine Maleate, Trimethoprim, Pentoxyphylline ...

Bulk drug prices revised  Dec 27, 2005
Business Standard, Authority (NPPA) has revised the prices of some bulk drugs and formulations, including Sodium and Procaine Penicillin G, Phenramine Maleate, Trimethoprim and ...

NPPA revamps bulk drugs/formulation prices  Dec 27, 2005
NewKerala.com, Meanwhile, the prices of bulk drugs Pheniramine Maleate, Trimethoprim, Rifampicin were revised upwards to Rs 1107/kg, Rs 840/kg, Rs 3560/kg from the existing ...

In fine health  Jan 8, 2006
Business Standard, ...companies. The company has also recently received tentative US FDA approval for its anti-diabetic drug, Rosiglitazone Maleate tablets. ...

BioDelivery Sciences Files IND for BEMA(TM) LA, a treatment for ...  Jan 9, 2006
dBusinessNews Triangle (press release), Needless to say, with our existing NDA for Emezine(R) (prochlorperazine maleate) under review at FDA; BEMA(TM) Fentanyl entering Phase III and now with our ...

Drug prices may face a small hike  Dec 28, 2005
Andhra Cafe, Also, prices of other bulk drugs such as pheniramine maleate and timethoprim have been raised by 3.65 and 20 per cent respectively. ...

Easing IBS  Jan 4, 2006
WOWT, Researchers are now testing the use of another drug, tegaserod maleate, can help prevent overgrowth of bacteria for longer periods of time.

Irritable Bowel Syndrome (IBS)  Dec 16, 2005
WSOCtv.com, Tegaserod maleate (Zelnorm®) is approved for women with IBS who have constipation as their main symptom. There aren't any conclusive diagnostic tests for IBS. ...

An Association Between Avandia® and Avandamet® and Vision ...  Dec 23, 2005
DG News MISSISAUGA, ONTARIO, CANADA -- December 23, 2005 -- Avandia(R) (rosiglitazone maleate) tablets and Avandamet(R) (rosiglitazone maleate/metformin hydrochloride ...

Pen G derivatives prices reduced by up to 32%  Dec 27, 2005
Financial Express, The authority also announced hike in prices of bulk pheniramine maleate (3.65%), trimethoprim (20%) and rifampicin (2.3%), citing rise in prices of raw ...

Novartis Remains Committed to Making Zelnorm Available for Women ...  Dec 15, 2005
PharmaLive.com (press release), Novartis markets Zelnorm® (tegaserod maleate) in the US, Canada, Philippines and South Africa; and under the trademark Zelmac® (tegaserod) in Switzerland ...

Sensex snaps 5-day rally; rupee climbs  Dec 14, 2005
Gulf Times, The company won approval to sell 2-milligram, 4-milligram and 8-milligram tablets of rosiglitazone maleate in the US, the drug regulator said in an e-mailed ...

Mother explains horrors of local OTC drug abuse  Dec 15, 2005
Atlanticville, C (CCC), a nickname for the cough medicine Coricidin HBP Cold & Cough, the most popular brand of dextromethorphan (DXM) and chlorpheniramine maleate that is ...


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