Indication: For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia.
Pharmacology: Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Chloroprocaine is an ester anesthetic.
Mechanism Of Action: Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Chloroprocaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
Drug Category: Anesthetics; Local Anesthetics; ATC:N01BA04
Interactions:
DrugBank: Interactions for Chloroprocaine
Interactions for Chloroprocaine:
The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving
monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension
or hypertension. Concurrent use of these agents should generally be avoided. In situations when concurrent therapy is
necessary, careful patient monitoring is essential.
Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and
ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.
The para-aminobenzoic acid metabolite of chloroprocaine inhibits the action of sulfonamides. Therefore,
chloroprocaine should not be used in any condition in which a sulfonamide drug is being employed.
Chemical IUPAC Name: 2-diethylaminoethyl4-amino-2-chloro-benzoate
Chemical Formula: C13H19ClN2O2
Half Life: 21 +/- 2 seconds
Drug Type: Approved Drug
# Accession No: APRD00404
CAS Registry Number: 133-16-4
Chloroprocaine News (When available)
Laser use becoming popularJan 1, 2006 Berkshire Eagle, ...said. By using the laser instead of the traditional drill, many dentists find that their patients require little to no Novocain. ...
Barry Tompkins: From sadists to good guysJan 12, 2006 Marin Independent-Journal, ..."I'm going to numb your gums now before I give you the Novocain that will numb the rest of your face for the next week and a half," says Janet, the dental ...
A little light drillingDec 28, 2005 North Adams Transcript, That's because Klemm uses a laser, which doesn't require injection of the traditional Novocain, for filling a cavity or performing oral surgery. ...
PEACHY KEENJan 3, 2006 Kingwood Now, ...rather than just sweet. Granulated sugar is like Novocain to your taste buds, so avoid overly sweetening if you can. The idea is ...
Laser Dentistry May Make Investors SmileDec 23, 2005 TheStreet.com (subscription), It must be done, yet the prospect is filled with fears of screeching drills, big needles filled with Novocain, sore gums and numb lips. ...
Authors don't just write — they read, tooDec 31, 2005 Milwaukee Journal Sentinel (subscription), It so shook me that I've decided not to die. A historical novel about the Oregon Trail - I know, I know, sounds like a trip to the dentist sans Novocain. ...
Wettest and bestJan 5, 2006 Pasadena Star-News, ...abuse of power, wielded by a Tournament of Roses board member who promised her the Rose crown if only she would allow him to hypnotize her in lieu of Novocain. ...
John Grogan | Resolved for '06: Let's get boringJan 2, 2006 Philadelphia Inquirer, Let's promise to not slip back into our collective, Novocain-numb apathy. Like all of us, politicians perform better when they know the boss is watching. ...
The gift of readingDec 18, 2005 The Journal News.com, ...beautiful style. A historical novel about the Oregon Trail — I know, I know, sounds like a trip to the dentist sans Novocain. But ...
Bulk drug prices revisedDec 27, 2005 Business Standard, National Pharmaceutical Pricing Authority (NPPA) has revised the prices of some bulk drugs and formulations, including Sodium and Procaine Penicillin G ...
NPPA FIXES/REVISES THE PRICES OF BULK DRUGS AND FORMULATIONSDec 27, 2005 Press Information Bureau (press release), Bulk Drugs – The prices of bulk drugs Sodium Penicillin G, Procaine Penicillin G, Benzathine Penicillin G, Phenramine Maleate, Trimethoprim, Pentoxyphylline ...
Pen G derivatives prices reduced by up to 32%Dec 27, 2005 Financial Express, ...of 1.2%. It cut prices of three penicillin G derivatives, namely sodium (32%), procaine (28%), and benzathine (17%). The authority ...
NPPA revamps bulk drugs/formulation pricesDec 27, 2005 NewKerala.com, Other drugs, whose prices have been decreased are Procaine penicillin G from Rs 1,357/BU to Rs 971/BU, and Benzathine Penicillin G from Rs 2469/kg to Rs 2055/kg ...
Drug prices may face a small hikeDec 28, 2005 Andhra Cafe, Also the NPPA decided to reduce prices of the bulk drugs sodium penicillin G, procaine penicillin G and Benzathine penicillin C by 31.73 per cent, 28.45 per ...
Boca man accused of unlicensed doctoringDec 29, 2005 Palm Beach Post, He left the room and came back with two unwrapped syringes. Brown then injected her with the liquid B and B-12 vitamins, folic acid and Procaine. ...
Thirty years on quinidine for paroxysmal ventricular tachycardiaDec 31, 2005 Journal of the Royal Society of Medicine Procaine amide and practolol had failed to give control and I started him on quinidine sulphate, in the form of Kinidin Durules (Astra), 2 g per day. ...
Skin Diseases in HorsesDec 22, 2005 TheHorse.com, A cure can normally be effected with a single intra-muscular injection of procaine penicillin (22,000 IU/kg) and streptomycin (22mg/kg). ...
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