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Chlordiazepoxide
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DRUG INFO
Chlordiazepoxide
Drug Name:
Chlordiazepoxide
Indication: For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
Pharmacology: Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Mechanism Of Action: Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. BZDs enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.
Drug Category: Anti-anxiety Agents; Hypnotics and Sedatives; Adjuvants, Anesthesia; Benzodiazepines; GABA Modulators; ATC:N05BA02
Brand Names/Synonyms: A-Poxide; Abboxide; Apo-Chlordiazepoxide; Balance; CD 2; CDO; CDP; Chloradiazepoxide; Chlordiazachel; Chlordiazepoxid; Chlordiazepoxide; Chlordiazepoxide Base; Chlordiazepoxide Hcl; Chlordiazepoxidum; Chloridazepoxide; Chloridiazepide; Chloridiazepoxide; Chlorodiazepoxide; Chlozepid; Clopoxide; Clordiazepossido; Contol; Control; Decacil; Eden; Elenium; Helogaphen; Ifibrium; Kalmocaps; Librax; Librelease; Librinin; Libritabs; Librium; Limbitrol; Limbitrol Ds; Lygen; Menrium; Mesural; Methaminodiazepoxide; Mildmen; Multum; Napoton; Napton; Novo-Poxide; Psicosan; Radepur; Risolid; Silibrin; Tropium; Viopsicol
Dosage Forms: CAPSULE (5 mg, 10 mg or 25 mg)
Absorption: Not Available
Interactions: Interactions for Chlordiazepoxide:
Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects an blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide.
The concomitant use of alcohol or other central nervous system depressants may have an additive effect.
Chemical IUPAC Name: 10-chloro-3-hydroxy-N-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-1,6,8,10-tetraen-5-imine
Chemical Formula: C16H14ClN3O
Half Life: 24-48 hours
Drug Type: Approved Drug
# Accession No: APRD00682
CAS Registry Number: 58-25-3
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Chlordiazepoxide News
(When available)
Curfew plan to contol unruly children Dec 25, 2005
Telegraph.co.uk, By George Jones, Political Editor. Tearaway children will be subject to tough control orders and night-time curfews even before they ...
YOUR REMOTE CONTOL GUIDE Dec 16, 2005
Glasgow Daily Record, When are the shows on STRICTLY COME DANCING BBC 1 Final show 6.30pm-7.50pm 9.20pm-10.10pm Results show . Bruce Forsyth and Tess ...
Engage to become first in-game ad agency Jan 10, 2006
Ars Technica, ...(Because it gives him wings!) With any luck, users will be able to contol the appearance of ads; after all, if I'm paying $50 for a game or $10 for a monthly ...
Russia turns down the gas Jan 2, 2006
National Business Review, Since Ukraine's Orange Revolution last year, however, which saw a pro-Western government acquire contol of the country, Moscow has been much at odds with ...
Lalu puts private sector on rails Jan 6, 2006
Hindustan Times, ...the Railways will provide the engines. The running of the trains will be under the contol of the Railways. The scheme is open to ...
Cornice introduces new 8GB and 10GB micro hard drives Jan 2, 2006
MobileWhack.com, Crash Guard includes features such as Active Latch, Skip Contol, and Drop Safe. The drives will be available for $85 a unit in quantities of 10,000. ...
I'll have Fergie's job Dec 27, 2005
The Sun, By GAVIN GLICKSMAN. Capello is happy in Italy with Juventus but has been widely tipped as one of the leading candidates to take contol at Old Trafford. ...
'Sanrasoft' unveils 'Rudra' Dec 21, 2005
NewKerala.com, New files, changes in configuration, changes in system contol files and changes in critical application program files were all evaluated for potential threats. ...
FG Approves N4.9bn for Air Force Plane, Power Dec 22, 2005
AllAfrica.com, Liyel said the national Contol Tower in Osogbo will cost N223 million, while the two regional sub-stations in Ikeja and Benin will gulp N143.9 million and N122 ...
Bison's defense rattles Blues Dec 28, 2005
Staunton News Leader, The full-court, man-to-man pressure forced 14 first-quarter turnovers when the Gap took contol 16-3, and had forced 27 by halftime when it led 30-10. ...
Board Holds Final 2005 Meeting Dec 28, 2005
Marshall County Journal, The letter also indicated that the Dairy had completed requirements to obtain coverage under the general water pollution contol permit for concentrated animal ...
Police: woman with stun gun stripped during call about dog Jan 11, 2006
Southeast Missourian, Also found were four pills of Klonopin, an anti-anxiety medication, and seven pills of Librax, a medication for the treating of peptic ulcer disease, the ...
Are we a country of pill takers? Jan 2, 2006
Cassopolis Vigilant, ...their futures. Sedatives, such as Valium, Xanax and Librium, are also being misused by the younger generation. Psychotherapeutic ...
Teens popping pills more than other drugs Jan 9, 2006
Boca Raton News, ...after a substantial rise in use.". Sedative use also increased, including Valium, Xanax and Librium. In 2005, nearly 8 percent of ...
Here's Looking at Jew, Kid Jan 3, 2006
Blogcritics.org, Allan: You want a Fresca with a Darvon? Allan: Apple juice and Darvon is fantastic together! Linda: Have you ever had Librium and tomato juice? ...
Girl Scouts can expand with move to Burnley Dec 20, 2005
Pocono Record, With the new addition of the Girl Scouts office, Burnley Workshop houses three non-profit United Way member agencies including Equi-librium, which is a horse ...
Prescription Drug Use Remains High Among Teens Dec 27, 2005
PR Web (press release), ...depressants and are similar to tranquilizers. Some names of sedatives include Valium, Xanax and Librium. In 2005, nearly 8 percent ...
Here's to you, Mrs Robinson Dec 26, 2005
Mail & Guardian Online, Elizabeth Sneddon (98), South Africa’s first speech and drama professor. Leo Sternbach (97), chemist who led development of Librium and Valium. ...
UK. Webasto dealers gain awards at London Boat Show Jan 12, 2006
BYM News (press release), ...during 2005. The companies honoured on the stand were BK Marine of Napton Junction, JPC Ltd of Wroxham and Keto of Poole. Further ...
Ozark fire district will charge nonresidents Jan 7, 2006
News-Leader.com, To make the law clear, the district approached its state senator, Bill Stouffer, R-Napton, who helped revise state laws to grant fire districts the power to ...
Wonderful Marguerite Dec 22, 2005
Kenilworth Weekly News, Brighton. She taught in Coventry, but joined the Women's Royal Air Force after her school was evacuated to Napton during the blitz. ...
Stouffer named chairman of Senate Transportation Committee Dec 19, 2005
Boonville Daily News, JEFFERSON CITY - State Senator Bill Stouffer, R-Napton, was chosen Thursday, Dec. 15, to head the Missouri Senate's committee dealing ...
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