Indication: For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria
Pharmacology: Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis.
Mechanism Of Action: Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side chain.
Drug Category: Anti-allergic Agents; Antihistamines; ATC:R06AE07; ATC:R06AE09
Absorption: mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine
Interactions:
DrugBank: Interactions for Cetirizine
Interactions for Cetirizine:
Pharmacokinetic interaction studies with cetirizine in adults were conducted with pseudoephedrine, antipyrine,
ketoconazole, erythromycin and azithromycin. No interactions were observed. In a multiple dose study of theophylline
(400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of
cetirizine was observed. The disposition of theophylline was not altered by concomitant cetirizine
administration.
Drug-Drug Interactions: No clinically significant drug interactions have been found with
theophylline at a low dose, azithromycin, pseudoephedrine, ketoconazole, or erythromycin. There was a small decrease
in the clearance of cetirizine caused by a 400-mg dose of theophylline; it is possible that larger theophylline doses
could have a greater effect.
Chemical IUPAC Name: 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]aceticacid
Chemical Formula: C21H25ClN2O3
Half Life: 8.3 hours
Drug Type: Approved Drug
# Accession No: APRD00630
CAS Registry Number: 83881-51-0
Cetirizine News (When available)
Epilepsy - UCB Receives EMEA Positive Opinion And FDA Approvable ...Feb 5, 2006 UCB key products are Keppra® (levetiracetam), Zyrtec®* (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex), and Equasym(TM ... - Medical News Today (press release),
Kopran licenses out all drug brands to SarabhaisJan 4, 2006 Business Standard, ...heart burn drug, Caditone (carvedilol) a Rs 0.03-crore anti-hypertension drug, Ketotif (ketotifen) an anti-asthma drug, Zimat (cetrizine dihydrochloride) a Rs ...
Loris councilman guilty of drug chargesJan 13, 2006 Myrtle Beach Sun News, ...to four charges of distributing the illegal drug hydrocone, two charges of distributing marijuana, possession of oxycodone and possession of Zyrtec without a ...
Some Cough Medicines May Hurt, Not HelpJan 14, 2006 Los Angeles Times, Dicpinigaitis said. Newer, brand-name antihistamines such as Claritin and Zyrtec do not help coughs, Dicpinigaitis said. Under the ...
Experts sniff at cough syrupsJan 11, 2006 Independent Online, ...chlorpheniramine, he said. Newer, brand-name antihistamines such as Claritin and Zyrtec did not help coughs, Dicpinigaitis said. Under new ...
Chest doctors discourage use of over-the-counter cough syrupJan 9, 2006 Austin American-Statesman (subscription), This includes drugs such as Benadryl and Dristan. Newer, expensive antihistamines such as Allegra, Claritin and Zyrtec do not help, the group said. ...
Cough syrups get the cold shoulder from doctors groupJan 10, 2006 Columbus Dispatch, Allergy. Newer, more expensive antihistamines do not help a cough, the group said. Those includes Allegra, Claritin and Zyrtec. Over ...
Panel Sees Over-the-Counter Cough Medicines as UselessJan 11, 2006 Newsinferno.com, ...coughs. Newer brand name OTC antihistamines, however, such as Zyrtec and Claritin for example, do not help coughs experts say. Even ...
City Councilman resignsJan 12, 2006 Myrtle Beach Sun News, ...and July 5. Those drugs included hydrocodone, marijuana, OxyContin, Zyrtec 10, buspirone hydrochloride and ranitidine. He also is ...
News & NotesDec 19, 2005 St. Petersburg Times, ...bumming around, he eventually settled down and took over his father's ad firm, where he came up with some memorable ads for monster.com, Zyrtec and LensCrafters ...
Non-prescription cough medicine won't help that coughJan 9, 2006 News-Medical.net, ...older-generation antihistamines that work against coughs which include chlorpheniramine, newer, brand-name antihistamines such as Claritin and Zyrtec will not ...
