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Cerulenin
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DRUG INFO
Cerulenin
Drug Name:
Cerulenin
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Indication: For use as a biochemical tool, Cerulenin is shown to cause dramatic weight loss in animals
Pharmacology: Cerulenin is an antifungal antibiotic isolated from Cephalosporium caerulens. It interrupts fungal growth by inhibiting the biosynthesis of sterols and fatty acids (inhibits bacterial fatty acid synthesis). It also inhibits HMG-CoA synthetase activity. Cerulenin produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors.
Mechanism Of Action: Irreversibly binds to fatty acid synthase, specifically b-ketoacyl-acyl carrier protein synthase (FabH, FabB and FabF condensation enzymes). A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FAS). Inhibition of FAS by cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.
Drug Category: Antibiotics, Antifungal; ATC:J04
Brand Names/Synonyms: Cerulenin; Cerulenin From Cephalosporium Caerulens; Helicocerin
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 3-nona-4,7-dienoyloxirane-2-carboxamide
Chemical Formula: C12H17NO3
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00703
CAS Registry Number: 17397-89-6
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