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DRUG INFO
Cephalexin
Drug Name:
Cephalexin
Indication: For the treatment of respiratory, skin, soft tissue, urintary tract infections caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Pharmacology: Cephalexin is a first-generation cephalosporin antibiotic which is effective against most gram-positive bacteria. Cephalexin is used to treat otitis media and respiratory tract infections caused by susceptible staphylococci, Streptococcus pneumoniae, and group A beta-hemolytic streptococci.
Mechanism Of Action: Cephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.
Drug Category: Anti-bacterial Agents; Cephalosporins; ATC:J01DB01
Brand Names/Synonyms: Alcephin; Alexin; Alsporin; Biocef; CEX; Carnosporin; Cefa-Iskia; Cefablan; Cefadal; Cefadin; Cefadina; Cefaleksin; Cefalessina [Dcit]; Cefalexin; Cefalexin Sodium; Cefalexina [Inn-Spanish]; Cefalexine [Inn-French]; Cefalexinum [Inn-Latin]; Cefalin; Cefaloto; Cefaseptin; Cefax; Ceforal; Cefovit; Celexin; Cepastar; Cepexin; Cephacillin; Cephalexin; Cephalexin Hydrate; Cephalexin Monohydrate; Cephalexine; Cephalexinum; Cephanasten; Cephaxin; Cephin; Cepol; Ceporex; Ceporex Forte; Ceporexin; Ceporexin-E; Ceporexine; Check; Cophalexin; Durantel; Durantel Ds; Ed a-Ceph; Erocetin; Factagard; Felexin; Fexin; HSDB
Dosage Forms: SUSPENSION; TABLET
Absorption: It is rapidly absorbed after oral administration by the gastrointestinal tract
Interactions:
DrugBank: Interactions for Cephalexin
Interactions for Cephalexin:
Metformin ó In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma
metformin mean cmax and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal
clearance decreased by 14%. No information is available about the interaction of cephalexin and metformin following
multiple doses of either drug.
Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin
and metformin by inhibition of tubular secretion via organic cationic transporter systems. Accordingly, careful
patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and
metformin.
Probenecid ó As with other b -lactams, the renal excretion of cephalexin is
inhibited by probenecid.
Drug / Laboratory Test Interactions
As a result of administration of Keflex, a false-positive reaction for glucose in the urine may occur. This has
been observed with Benedictís and Fehlingís solutions and also with Clinitest® tablets.
Chemical IUPAC Name: 8-(2-amino-2-phenyl-acetyl)amino-4-methyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid
Chemical Formula: C16H17N3O4S
Half Life: 1hr
Drug Type: Approved Drug
# Accession No: APRD00250
CAS Registry Number: 15686-71-2
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Advancis Pharmaceutical Reports Fourth Quarter and Full Year 2005 ... 09 Feb 2006
Product Sales - Keflex(R) (cephalexin capsules, USP) Advancis reported net Keflex sales of $1.6 million in the fourth quarter of 2005, up from $1.3 million in ... - PR Newswire (press release),
Health Groups Raising Awareness on Misuse of Antibiotics Jan 25, 2006
Meijer pharmacies are collecting Amoxicillan, Zithromax, Cephalexin and other antibiotics that are used to treat bacterial infections. ... - WLNS,
Hikma part-owned plant given FDA approval Jan 25, 2006
The group said the "US FDA has approved its Abbreviated New Drug Application (ANDA) filings for the oral cephalosporin, Cephalexin in 250mg and 500 mg capsule ... - ShareCast,
GeoPharma Reports 80% Increase in Third Quarter 2006 Revenues; EPS ... Feb 1, 2006
Additions to our Cephalexin plant are progressing and the Consolidated Pharmaceutical facility we acquired in August is on track for FDA inspection and the ... - PR Newswire (press release),
Strep throat grows stronger Feb 3, 2006
By contrast, 14 percent of children receiving older generation cephalosporin antibiotics such as cephalexin, and only 7 percent of children receiving newer ... - Quad City Times,
Kids tee off Jan 10, 2006
By contrast, 14 percent of children receiving older- generation cephalosporin antibiotics such as cephalexin, and only 7 percent of children receiving newer ... - Indianapolis Star,
Underground resistance Jan 19, 2006
More than 90 percent were resistant to cephalexin, used to treat pneumonia and urinary tract infections, and one in 10 resisted the anti-anthrax drug ... - Newsday,
Retapamulin demonstrates promising activity against pathogens ... Jan 10, 2006
...the potential for S. aureus to develop resistance to Retapamulin and seven other commonly-used antibacterials, including Mupirocin, Cephalexin, Vancomycin and ... - Xagena.it,
Stock Watch Jan 24, 2006
It received two ANDA approvals viz. for Lisinopril Tablets and Cephalexin suspension respectively during the quarter under review. ... - Express Pharma Pulse,
Derbys gearing up for the playoffs Jan 10, 2006
Mississauga News, The Derbys plucked power forward Steve Tamaridis from the Toronto Thunderbirds and also picked up forwards Mike Sheu and Brent Alexin from the Buffalo Junior ...
