Cefprozil resources


DRUG INFO
Cefprozil

Drug Name: Cefprozil

Indication: For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph



Pharmacology: Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.

Mechanism Of Action: Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.

Drug Category: Anti-bacterial Agents; Cephalosporins; ATC:J01DC10

Brand Names/Synonyms: Arzimol; Brisoral; Cefprozil anhydrous; Cefprozilo [INN-Spanish]; Cefprozilum [INN-Latin]; Cefzil; Cronocef; Procef; Serozil

Dosage Forms: Cefzil tablets contain cefprozil equivalent to 250 mg or 500 mg of anhydrous cefprozil.

Absorption: Oral_~95%

Interactions: Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics. Concomitant administration of probenecid doubled the AUC for cefprozil. The bioavailability of the capsule formulation of cefprozil was not affected when administered 5 minutes following an antacid.



Chemical IUPAC Name: 8-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-7-oxo-4-prop-1-enyl-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Chemical Formula: C18H19N3O5S

Half Life: 1.3 hours

Drug Type: Approved Drug

# Accession No: APRD00461

CAS Registry Number: 92665-29-7



Cefprozil News
(When available)



Orchid receives USFDA nod for Cefprozil tablets  Jan 24, 2006
...based pharma major, Orchid Chemicals & Pharmaceuticals announced that it has received the formal approval from the USFDA for its ANDA for Cefprozil tablets USP ... - Express Pharma Pulse,

Third-quarter earnings perk up Lupin by 5%  Jan 30, 2006
...investment of Rs 26 crore. Lupin launched five products in the US market in the quarter, which included Cefprozil suspension and tablets. - Business Standard,

First-Time Generic Approvals: Zithromax, Cefzil, Zonegran  Jan 27, 2006
...the treatment of community-acquired pneumonia and for pelvic inflammatory disease caused by susceptible strains of designated microorganisms; cefprozil 125-mg/5 ... - Medscape (subscription)

Lupin hunts for brand buyouts in US, Europe  Feb 3, 2006
The company launched five products in the US market in the last quarter, which included Cefprozil suspension and tablets on patent expiry. - Daily News & Analysis,

Orchid Q3 turnover up  Jan 19, 2006
The growth momentum of the second quarter (Q2) has been sustained with the ramp-up of Ceftriaxone injection and introduction of Cefprozil tablets and ... - Webindia123,

for Oral Suspension  Jan 18, 2006
...recently announced that it had received final approval from the FDA for its Abbreviated New Drug Application for cefprozil for oral suspension. ... - Pharmaceutical Processing,

Orchid gets USFDA nod for Cefoxitin  Jan 27, 2006
Director K Raghavendra Rao. The current US market size for Cefprozil tablets is estimated at 117 million dollars. This is the eighth ... - NewKerala.com,

Zacks.com Announces That Vivian Lewis Highlights the Following ...  Jan 17, 2006
C virus. It also won FDA ok for cefprozil in tablet and oral form, and oxydine in 3 doses including extended release. Successful ... - Business Wire (press release), Par Pharmaceutical Receives Final Approval To Market Generic ...  Dec 30, 2005
PR Newswire (press release), Cefprozil is the generic version of Bristol-Myers Squibb Company's broad-spectrum cephalosporin antibiotic Cefzil(R). Annual US sales of Cefzil(R) for Oral ...

Par Pharmaceutical Receives Final Approval To Market Generic ...  Dec 30, 2005
Yahoo! News (press release) Cefprozil is the generic version of Bristol-Myers Squibb Company's broad-spectrum cephalosporin antibiotic Cefzil®. Annual US sales ...

First-Time Generic Approvals: Dilaudid, Cefzil, Zithromax  Dec 30, 2005
Medscape (subscription) 14, the FDA approved first-time generic formulations of cefprozil 250- and 500-mg tablets (made by Sandoz, Inc; brand name Cefzil, made by Bristol-Myers Squibb ...

Business briefs  Dec 31, 2005
NorthJersey.com, Cefprozil is the generic version of Bristol-Myers Squibb Co.'s cephalosporin antibiotic Cefzil. Annual US sales of Cefzil exceed ...

Wal-Mart delays opening until the spring  Dec 31, 2005
The Journal News.com, Cefprozil, which is used to treat infections, is the generic version of Bristol-Myers Squibb Co.'s cephalosporin antibiotic Cefzil. ...

Orchid Chemicals’ drug gets USFDA nod  Jan 2, 2006
Sify, ...that it had received approval from the US Food and Drug Administration for a generic of an oral suspension form of Bristol-Myers Squibb's antibiotic Cefzil. ...

Stocks set to open up on oil prices  Dec 27, 2005
BusinessWeek ...for its abbreviated new-drug application for cefprozil, the generic version of Bristol-Myers Squibb Co.'s broad-spectrum cephalosporin antibiotic Cefzil. ...

Lupin gets USFDA nod for Cefprozil suspension  Dec 20, 2005
Business Standard, According to a release issued by Lupin to the BSE today, Cefprozil is the generic equivalent of Bristol Myers Squibb’s Cefzil. ...

Lupin gets US FDA nod for Cefprozil oral suspension  Dec 20, 2005
Webindia123, ...the USFDA for Cefprozil tablets. Cefprozil is the generic equivalent of Bristol Myers Squibb's Cefzil®. The suspension market in ...

Lupin wins USFDA okay for Cefprozil suspension  Dec 20, 2005
India Infoline.com, ...ml and 250 mg/5 ml. Cefprozil is the generic equivalent of Bristol Myers Squibb's Cefzil. The American market for Cefprozil Oral ...

Par Pharmaceutical gets FDA approval for cefprozil drug  Dec 30, 2005
Reuters The company said cefprozil is the generic version of Bristol-Myers Squibb Co.'s (BMY.N: Quote, Profile, Research) broad-spectrum cephalosporin antibiotic Cefzil ...

US FDA approves Lupin's cefprozil suspension, Orchid's tablets  Dec 20, 2005
domain-B, Cefprozil is the generic equivalent of Bristol Myers Squibb's Cefzil. The suspension market in the US is valued at $119 million. ...

Par Pharmaceuticals Antibiotic Approved  Dec 23, 2005
Schaeffers Research, ...received approval from the US Food and Drug Administration to market cefprozil, an antibiotic which is the generic version of Bristol-Myers Squibb Co.'s Cefzil ...

Par gets FDA approval for infection treatment  Dec 30, 2005
NewYorkBusiness.com, ...such as bronchitis, tonsillitis, or ear infections and is a generic version of Bristol-Myers Squibb Co.'s cephalosporin antibiotic Cefzil, which generates more ...

Indian shares end off new peak  Jan 2, 2006
Daily Times, ...after it said it had approval from the US Food and Drug Administration for a generic of an oral suspension form of Bristol-Myers Squibb’s antibiotic Cefzil. ...

Orchid Chemicals gets USFDA nod for Cefprozil oral suspension  Jan 1, 2006
Hindu Business Line, Par). Cefprozil, an anti-biotic, is the generic version of Bristol-Myers Squibb's broad-spectrum Cephalosporin antibiotic Cefzil. ...

Orchid Chemicals gets USFDA nod for Cefprozil susp  Jan 2, 2006
India Infoline.com, ...mg /5 ml. Cefprozil is the generic version of Bristol-Myers Squibb's broad-spectrum cephalosporin antibiotic Cefzil. The current ...

Orchid Chemicals gets USFDA nod for Cefprozil oral suspension  Jan 2, 2006
Webindia123, The Company informed the BSE that Cefprozil is the generic version of Bristol-Myers Squibb's broad-spectrum cephalosporin antibiotic Cefzil. ...

Orchid Chemicals receives US FDA approval for Cefprozil  Jan 2, 2006
New Ratings ...suspension at $120 million. Cefprozil is a generic version of Bristol-Myers Squibb's (BMY) Cefzil. Orchid Chemicals & Pharmaceuticals ...

Par gets US FDA nod for antibiotic cefprozil  Dec 23, 2005
Reuters Cefprozil is the generic version of Bristol-Myers Squibb Co.'s (BMY.N: Quote, Profile, Research) broad-spectrum cephalosporin antibiotic Cefzil, whose annual ...

Corporate Briefs  Dec 23, 2005
Calcutta Telegraph, ...its cefprozil oral suspension of 125mg/5ml and 250mg/5ml. Cefprozil is the generic equivalent of Bristol Myers Squibb’s cefzil.

(PRN) - Certegy Inc. to Acquire Assets of FastFunds Financial ...  Dec 23, 2005
Bolsamania.com, Share Offer ... [+. PRN) - Par Pharmaceutical Receives Final Approval to Market Generic Cefzil(R) Tablets ... [+. PRN) - Bookstore ...

(PRN) - JB Oxford Announces Effectiveness of Reverse Stock Split . ...  Dec 30, 2005
Bolsamania.com, Washington ... [+. PRN) - Par Pharmaceutical Receives Final Approval To Market Generic Cefzil(R) For Oral Suspension ... [+. PRN ...


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