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Cefixime
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DRUG INFO
Cefixime
Drug Name:
Cefixime
Indication: For the treatment of the following infections (UTI, respiratory, ENT) caused by; E.coli, P.mirabilis, H.influenzae (beta-lactamase positive and negative strains), M.catarrhalis, (most of which are beta-lactamase positive), S. pyogenes, S.pneumoniae, N.gon
Pharmacology: Cefixime, an antibiotic, a third-generation cephalosporin like ceftriaxone and cefotaxime, is used in the treatment of otitis media, and respiratory tract and urinary tract infections. The antibacterial effect results from inhibition of mucopeptide synthesis in the bacterial cell wall
Mechanism Of Action: Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.
Drug Category: Anti-bacterial Agents; Cephalosporins; ATC:J01DD08
Brand Names/Synonyms: CFIX; Cefixim; Cefixima [Spanish]; Cefixime; Cefixime Anhydrous; Cefixime [Usan:Ban:Inn:Jan]; Cefiximum [Latin]; Cefixoral; Cefspan; Cephoral; FK 027; Oroken; Suprax; Unixime
Dosage Forms: Oral Suspension; Tablet; POWDER FOR SOLUTION; POWDER FOR SUSPENSION
Absorption: Orally 40-50%
Interactions:
DrugBank: Interactions for Cefixime
Interactions for Cefixime:
Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience
when SUPRAX is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in
carbamazepine plasma concentrations.
Warfarin and Anticoagulants: Increased prothrombin time, with or without clinical bleeding,
has been reported when cefixime is administered concomitantly.
Drug/Laboratory Test Interactions
A false-positive reaction for ketones in the urine may occur with tests using nitroprusside but not
with those using nitroferricyanide.
The administration of SUPRAX may result in a false-positive reaction for glucose in the urine using
ClinitestÒ**, Benedictís solution, or Fehlingís solution.
It is recommended that glucose tests based on enzymatic glucose oxidase reactions (such as
Clinistix®** or Tes-TapeÒ**) be
used. A false-positive direct Coombs test has been reported during treatment with other cephalosporin antibiotics;
therefore, it should be recognized that a positive Coombs test may be due to the drug.
Chemical IUPAC Name: 8-[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino-4-ethenyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
Chemical Formula: C16H15N5O7S2
Half Life: 3-4 hours
Drug Type: Approved Drug
# Accession No: APRD00583
CAS Registry Number: 79350-37-1
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Cefixime News
(When available)
Lupin to focus on paediatric products in US Jan 6, 2006
Sify, Check out. Lupin had launched paediatric antibiotic Suprax in the US in April 2004 and spent about $8 million on its promotion last year. ...
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