Cefaclor resources

DRUG INFO
Cefaclor

Drug Name: Cefaclor

Indication: For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A ß-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

Pharmacology: Cefaclor, a second generation cephalosporin with a spectrum resembling first-generation cephalosporins, is used to treat otitis media, sinusitis, and upper respiratory tract infection caused by ampicillin or amoxicillin-resistant H. influenzae. Alsos used to treat ear, lung, skin, throat, and urinary tract infections.

Mechanism Of Action: Cefaclor, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that cefaclor interferes with an autolysin inhibitor.

Drug Category: Anti-bacterial Agents; Cephalosporins; ATC:J01DC04

Brand Names/Synonyms: Alenfral; Alfacet; Alfatil; CCL; Ceclor; Ceclor Cd; Cefaclor; Cefaclor Anhydrous; Cefaclorum; Cefaclorum [Inn-Latin]; Cephaclor; Distaclor; Kefral; Kefral, Raniclor; Panacef; Panoral; Raniclor; S 6472

Dosage Forms: CAPSULE; POWDER; POWDER FOR SOLUTION; POWDER FOR SUSPENSION; SUSPENSION

Absorption: Well absorbed after oral administration, independent of food intake

Interactions: DrugBank: Interactions for Cefaclor

Interactions for Cefaclor:

No information provided.

Chemical IUPAC Name: 8-(2-amino-2-phenyl-acetyl)amino-4-chloro-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Chemical Formula: C15H14ClN3O4S

Half Life: 0.6-0.9 hour

Drug Type: Approved Drug

# Accession No: APRD00243

CAS Registry Number: 53994-73-3

Cefaclor News
(When available)

Second mix-up at pharmacy Jan 31, 2006
...try another antibiotic. He prescribed cefaclor, dispensed as ceclor, and City Health Pharmacy filled the prescription. After three ... - Manawatu Standard,

Preserving Competition, FTC Requires Divestitures Before Allowing ...  Jan 23, 2006
...to develop and market the following generic drugs: 1) amoxicillin clavulanate potassium from IVAX, to be divested to Par; 2) long-acting cefaclor (cefaclor LA ... - PharmaLive.com (press release), Businesses propose political pact to improve Murcia's image  Dec 15, 2005
Typically Spanish, ...of the region. The initiative comes from the business organisations Croem, Coec and Ceclor and the Chambers of Commerce. They say ...

Canadian drug maker coming to town  Dec 28, 2005
Indianapolis Star, Eli Lilly and Co. Lilly made antibiotics such as Ceclor its bread-and-butter products in the 1970s and 1980s. Now, Targanta will ...

Cefaclor resources

DRUG INFO Cefaclor

Interactions for Cefaclor:

DRUG INFO
Cefaclor