Carboplatin resources


DRUG INFO
Carboplatin

Drug Name: Carboplatin

Indication: For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide.



Pharmacology: Carboplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Mechanism Of Action: Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

Drug Category: Antineoplastic Agents; ATC:L01XA02

Brand Names/Synonyms: Cbdca; Carboplatin (USAN); cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II); Platinum(II), (1, 1-cyclobutanedicarboxylato)diammine-, cis-; Platinum, {diammine[1,1-cyclobutanedicarboxylato(2-)-O,O']-,} (SP-4-2)-; Platinum, diamine(1, 1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)-; Paraplatin; Paraplatin-AQ

Dosage Forms: SOLUTION

Absorption: Not Available

Interactions: Interactions for Carboplatin: The renal effects of nephrotoxic compounds may be potentiated by Carboplatin.



Chemical IUPAC Name: platinum;cyclobutane-1,1-dicarboxylicacid;azanide

Chemical Formula: C6H12N2O4Pt2

Half Life: 1.1-2 hours

Drug Type: Approved Drug

# Accession No: APRD00466

CAS Registry Number: 41575-94-4



Carboplatin News
(When available)



Gemzar® May Improve Results of Taxol®/Paraplatin® Regimen for ...  09 Feb 2006
Researchers from Italy have reported that the addition Gemzar® (gemcitabine) to Taxol (paclitaxel)/Paraplatin (carboplatin) improves survival of patients with ... - Cancer Consultants (press release),

Telik Announces Fourth Quarter and 2005 Year End Financial Results ...  09 Feb 2006
The ASSIST-3 trial was initiated to evaluate the combination of TELCYTA plus carboplatin in second-line platinum refractory or resistant ovarian cancer. ... - Yahoo! News (press release)

Addition of Gemzar® to Paclitaxel/Carboplatin Improves Survival ...  Jan 31, 2006
...addition of the chemotherapy agent Gemzar (gemcitabine) to the commonly used chemotherapy regimen paclitaxel (Taxol®) plus carboplatin (Paraplatin®) appears ... - Cancer Consultants (press release),

InterMune Discontinues Ovarian Cancer Trial  Feb 2, 2006
GRACES was a Phase III trial comparing carboplatin plus paclitaxel (standard of care chemotherapy) combined with Actimmune(R) to carboplatin plus paclitaxel ... - PR Newswire (press release),

InterMune Halts All Cancer Research Into Actimmune  Feb 3, 2006
The study compared the combination of Actimmune with the standard regimen of carboplatin and paclitaxel to the two chemo agents alone in advanced ovarian cancer ... - BioWorld Online (subscription),

Doxil®/Eloxatin® May Provide a Treatment Option in Advanced ...  Feb 6, 2006
...included women with recurrent ovarian cancer who had previously been treated with a regimen containing a platinum agent (Paraplatin® [carboplatin] or Platinol ... - Cancer Consultants (press release),

Novel Strategies for Treating Lung Cancer: Chemotherapy  Jan 24, 2006
...and apoptotic effect, and it has shown activity in a number of human cancer cell lines, without cross-resistance with cisplatin, carboplatin, or paclitaxel. ... - Medscape (subscription)

Cisplatin Benefits Patients with Metastatic Osteosarcoma  Jan 12, 2006
...of two clinical trials suggests that the chemotherapy drug cisplatin is more effective against metastatic osteosarcoma than the chemotherapy drug carboplatin. ... - Cancer Consultants (press release),

BioSphere Medical Reports Fourth Quarter and Full Year 2005 ...  Feb 2, 2006
Publication in the December 2005 Journal of Vascular Interventional Radiology - Effects of the Type of Embolization Particles on Carboplatin Concentration in ... - Genetic Engineering News,

Cytokinetics, Incorporated Reports Fourth Quarter and Year End ...  Jan 31, 2006
...a third dose-escalating Phase Ib clinical trial, designed to evaluate the safety, tolerability and pharmacokinetics of ispinesib in combination with carboplatin ... - PR Newswire (press release),

Update on Adjuvant Therapy for Breast Cancer: The Expanding Role ...  Jan 30, 2006
AC T]) vs the same chemotherapy plus trastuzumab (AC TH) vs a nonanthracycline triplet chemotherapy combination of docetaxel, carboplatin, and trastuzumab (TCH ... - Medscape (subscription)

InterMune Announces Fourth Quarter and Year End 2005 Financial ...  Feb 2, 2006
Monitoring Board (DSMB) on the Phase III GRACES trial evaluating Actimmune(R) in combination with standard of care chemotherapy (carboplatin/paclitaxel) in the ... - PR Newswire (press release),

Hearing loss from chemotherapy underestimated  Jan 8, 2006
A study published in the Journal of Clinical Oncology found that the frequency and severity of ototoxicity from the chemotherapy ( Carboplatin, Cisplatin ), as ... - Xagena.it,

Individualized Treatment May Be Best in Testicular Cancer  Jan 11, 2006
...toxicity. Relapses were seen in 6 (6.0%) of patients on surveillance and 7 (3.3%) of those who were treated with carboplatin. All ... - Cancerpage.com,

Struggle shows obstacle  Jan 28, 2006
...incurred.". Dakhil originally prescribed Bowles a combination of three drugs -- carboplatin, Gemzar (gemcitabine) and Taxol (paclitaxel). ... - Kansas.com,

Chemotherapy for Childhood Cancer: Side Effects on Hearing  Jan 27, 2006
One common group of medications used to treat some childhood cancers are platinum-based drugs (like cisplatin and carboplatin). ... - WSOCtv.com,

Response to Chemotherapy May Guide Treatment of Patients with ...  Feb 1, 2006
IV laryngeal cancer. The initial cycle of chemotherapy involved cisplatin or carboplatin along with flouorouracil. The response ... - Cancer Consultants (press release),

Abdominal chemo boosts survival in ovarian cancer patients  Jan 8, 2006
...tumor ( debulking ), followed by six to eight courses of IV chemotherapy given every three weeks with a platinum drug, such as cisplatin or carboplatin, and a ... - PressZoom (press release),

RCT's Chad Souvignier Gets Promotion  Jan 17, 2006
...role in the commercial success of some of today's landmark pharmaceuticals and diagnostics, including the anticancer drugs cisplatin and carboplatin, the PSA ... - Genetic Engineering News,

Oregon study claims hearing damage from chemotherapy goes ...  Jan 16, 2006
Johnson, now 33, has suffered since 1986 from the effects of ototoxicity, a condition in which platinum-based chemotherapy drugs, such as carboplatin and the ... - Newstarget.com,

Chinese Herbal Medicine May Increase Effectiveness of Lung Cancer ...  Jan 20, 2006
Chemotherapy regimens that include a platinum-based drug such as carboplatin are often used in the treatment of advanced NSCLC, but frequently cause ... - Cancer Consultants (press release),

Lilly's Gemzar For Ovarian Cancer To Receive Oncologics Cmte. ...  Jan 19, 2006
Lilly is seeking approval for the use of Gemzar (gemcitabine) in combination with carboplatin for the treatment of patients with advanced ovarian cancer that ... - FDA Advisory Committee

Chemotherapy after surgery extends survival for patients with ...  Jan 20, 2006
Another GOG study is underway to see if the chemotherapy drugs Carboplatin and Paclitaxel will be as effective, but with fewer serious side effects. ... - Xagena.it,

Cytokinetics Raising $33M For Clinic, Corporate Uses  Jan 18, 2006
...patients. In addition, GSK is evaluating the drug in combination with docetaxel, carboplatin and capecitabine in three Phase Ib trials. ... - BioWorld Online (subscription),

Human Genome Sciences Reports on Progress Toward Commercialization ...  Jan 10, 2006
A Phase 1 and pharmacological study of HGS-ETR1, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid ... - PR Newswire (press release),

Herceptin plus chemotherapy improves disease-free survival in ...  Jan 7, 2006
2001 and February 2004. - an experimental regimen of Taxotere and Carboplatin with one year of Herceptin ( TCH ). Reduction in risk ... - Xagena.it, Erbitux® Plus Gemzar®/Paraplatin® Promising for Stage IV NSCLC  Dec 19, 2005
Cancer Consultants (press release), ...in the Journal of Clinical Oncology, the treatment combination consisting of Erbitux (cetuximab) plus Gemzar (gemcitabine) and Paraplatin (carboplatin) appears ...

Preferred Treatment for Advanced Ovarian Cancer: Questions and ...  Jan 5, 2006
Food Consumer, Platinum, which include cisplatin (or Platinol) and carboplatin (or Paraplatin), have the element platinum as part of their molecular structure. ...

Intraperitoneal Chemotherapy Effective for Ovarian Cancer  Jan 5, 2006
Cancer Consultants (press release), The number of protocol cycles of therapy was 6 and Paraplatin (carboplatin) was substituted for patients intolerant to Platinol. ...

Christmas tree pickup established at 3 parks  Dec 27, 2005
Beaumont Enterprise, Trees stripped of their stands, decorations and any plastics can be left at Rogers Park at Dowlen and Gladys; Sprott Park at Usan and Virginia; and Magnolia ...

Clemson 52, Winthrop 51  Dec 20, 2005
Gainesville Sun, ...usan Yenser's putback in the final second gave Clemson a 52-51 win over Winthrop on Tuesday night. The Lady Tigers (5-6) led 48-37 ...


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