Indication: For symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis
Pharmacology: Carbinoxamine is an antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. Rather than preventing the release of histamine, as do cromolyn and nedocromil, carbinoxamine competes with free histamine for binding at HA-receptor sites. Carbinoxamine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Ethanolamine derivatives have greater anticholinergic activity than do other antihistamines, which probably accounts for the antidyskinetic action of carbinoxamine.
Mechanism Of Action: Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown.
Interactions:
DrugBank: Interactions for Carbinoxamine
Interactions for Carbinoxamine:
Antihistamines may enhance the effects of tricyclic antidepressants, barbiturates, alcohol, and other CNS
depressants. MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Sympathomimetic
amines may reduce the antihypertensive effects of reserpine, veratrum alkaloids, methyldopa and mecamylamine. Effects
of sympathomimetics are increased with MAO inhibitors and beta adrenergic blockers.
Chemical IUPAC Name: 2-sulfanylethanesulfonicacid
Chemical Formula: C16H19ClN2O
Half Life: 10 to 20 hours
Drug Type: Approved Drug
# Accession No: APRD00765
CAS Registry Number: 486-16-8
Carbinoxamine News (When available)
Trainer Holloway Disqualified Over Drugs16 Jan 2006 Virtual Form Guide, Both Holloway and Hedges denied giving the six-year-old the substance Acepromazine Maleate, commonly known as Ace, and offered that it could have been done by ...
NSW stewards inquiry into tranquiliser findJan 13, 2006 ThoroughbredNews.co.nz, 1pm on Monday, 16 January 2006, following the Analyst's report of the presence of a metabolite of the veterinary tranquiliser Acepromazine Maleate being found ...
NPPA FIXES/REVISES THE PRICES OF BULK DRUGS AND FORMULATIONSDec 27, 2005 Press Information Bureau (press release), Bulk Drugs – The prices of bulk drugs Sodium Penicillin G, Procaine Penicillin G, Benzathine Penicillin G, Phenramine Maleate, Trimethoprim, Pentoxyphylline ...
Bulk drug prices revisedDec 27, 2005 Business Standard, Authority (NPPA) has revised the prices of some bulk drugs and formulations, including Sodium and Procaine Penicillin G, Phenramine Maleate, Trimethoprim and ...
NPPA revamps bulk drugs/formulation pricesDec 27, 2005 NewKerala.com, Meanwhile, the prices of bulk drugs Pheniramine Maleate, Trimethoprim, Rifampicin were revised upwards to Rs 1107/kg, Rs 840/kg, Rs 3560/kg from the existing ...
In fine healthJan 8, 2006 Business Standard, ...companies. The company has also recently received tentative US FDA approval for its anti-diabetic drug, Rosiglitazone Maleate tablets. ...
BioDelivery Sciences Files IND for BEMA(TM) LA, a treatment for ...Jan 9, 2006 dBusinessNews Triangle (press release), Needless to say, with our existing NDA for Emezine(R) (prochlorperazine maleate) under review at FDA; BEMA(TM) Fentanyl entering Phase III and now with our ...
Drug prices may face a small hikeDec 28, 2005 Andhra Cafe, Also, prices of other bulk drugs such as pheniramine maleate and timethoprim have been raised by 3.65 and 20 per cent respectively. ...
Easing IBSJan 4, 2006 WOWT, Researchers are now testing the use of another drug, tegaserod maleate, can help prevent overgrowth of bacteria for longer periods of time.
Irritable Bowel Syndrome (IBS)Dec 16, 2005 WSOCtv.com, Tegaserod maleate (Zelnorm®) is approved for women with IBS who have constipation as their main symptom. There aren't any conclusive diagnostic tests for IBS. ...
Pen G derivatives prices reduced by up to 32%Dec 27, 2005 Financial Express, The authority also announced hike in prices of bulk pheniramine maleate (3.65%), trimethoprim (20%) and rifampicin (2.3%), citing rise in prices of raw ...
Novartis Remains Committed to Making Zelnorm Available for Women ...Dec 15, 2005 PharmaLive.com (press release), Novartis markets Zelnorm® (tegaserod maleate) in the US, Canada, Philippines and South Africa; and under the trademark Zelmac® (tegaserod) in Switzerland ...
Sensex snaps 5-day rally; rupee climbsDec 14, 2005 Gulf Times, The company won approval to sell 2-milligram, 4-milligram and 8-milligram tablets of rosiglitazone maleate in the US, the drug regulator said in an e-mailed ...
Mother explains horrors of local OTC drug abuseDec 15, 2005 Atlanticville, C (CCC), a nickname for the cough medicine Coricidin HBP Cold & Cough, the most popular brand of dextromethorphan (DXM) and chlorpheniramine maleate that is ...
FULL MONTE FOR TWISTON-DAVIESJan 6, 2006 Sportinglife.com, Nigel Twiston-Davies showed his stable remains in form when Montecorvino stayed on stoutly up the hill to take the Happy 40th Birthday Clare Fogarty Novices ...
Racing: Cool Guy picks up the flame for Twiston-DaviesDec 31, 2005 Independent, ...slate, a fresh start. And for the Gloucestershire trainer Nigel Twiston-Davies, today is entwined with such symbolism. Five days ago ...
CASBAA Files 12 Copyright Infringement ActionsJan 15, 2006 ag-IP-news Agency, ...enforcement actions. Pay-TV signal theft must be penalized as an unlawful practice,� said CASBAA CEO Simon Twiston Davies. “While ...
Llewellyn has no desire to settle for the quiet lifeJan 13, 2006 Telegraph.co.uk, ...widely acknowledged to work harder than most: Carl Llewellyn, who manages to combine two full-time careers in one, as stable jockey to Nigel Twiston-Davies and ...
Twiston-Davies star heads Wetherby fieldDec 26, 2005 ic Wales, ...today. The Nigel Twiston-Davies-trained Fundamentalist is poised to make his eagerly-awaited seasonal bow in the £50,000 contest. ...
WINDRUSH NOT A CLASSIC CERTAINTYJan 11, 2006 Sportinglife.com, Trainer Nigel Twiston-Davies is keen to see the results of routine tests on the eight-year-old before committing to a run in Saturday's £35,000 contest over ...
Baron ruled out of Classic dateJan 12, 2006 RTE.ie, ...miles and five furlongs. "He's fine but he's just not quite well enough to run," said trainer Nigel Twiston-Davies. We wanted to ...
Another win for WilliamsJan 6, 2006 GG Racing, Nigel Twiston-Davies showed his stable remain in form when Montecovino stayed on stoutly up the hill to take the Happy 40th Birthday Clare Fogarty Novices ...
CASBAA lodges Legal action against Filipino Cable platformJan 10, 2006 Televisionpoint.com, ...charges the legitimate cable TV industry is demonstrating full commitment to following through on enforcement actions," said CASBAA CEO Simon Twiston Davies. ...
CASBAA takes action against Filipino cable-TV operatorJan 11, 2006 Asia-Pacific Broadcasting Union (press release), CASBAA Chief Executive Officer, Simon Twiston Davies, said: “While a significant number of cable operators engaging in unauthorised broadcasting expressed ...
CHANDLER TARGET FOR FUNDAMENTALISTJan 6, 2006 Sportinglife.com, Nigel Twiston-Davies is hoping for an improved showing from Fundamentalist when he tackles the Victor Chandler Chase at Cheltenham on January 28. ...
KNIGHT FAVOURITE FOR CHEPSTOW GLORYDec 22, 2005 Sportinglife.com, Nigel Twiston-Davies' 11-year-old suffered a setback in training and will play no part in the extended three-mile-five-furlong feature. ...
AINTREE HERO BINDAREE BOWS OUTDec 29, 2005 Sportinglife.com, Trained by Nigel Twiston-Davies, the chestnut gelding landed the Grand National in 2002, added the Welsh equivalent a year and a half later and was being ...
Grand National winner Bindaree retiredDec 30, 2005 Thoroughbred Times, Trained by Nigel Twiston-Davies, the 11-year-old gelding by Roselier out of Flowing Tide, by Main Reef, won nine times and placed in nine other events in 40 ...
Joaaci faces Classic testJan 12, 2006 Ireland Online, Nigel Twiston-Davies is represented by Shardam, but not last year’s winner Baron Windrush, who misses the race after developing an infection. ...
Glassonbury shows skill on StrandJan 7, 2006 Ireland Online, The Nigel Twiston-Davies-trained gelding was having his first run for 294 days after he finished “jarred up� after his last start. ...
Thornton hopes high for RembrandtJan 12, 2006 Ireland Online, Nigel Twiston-Davies is represented by Shardam, but not last year’s winner Baron Windrush,who misses the race after developing an infection. ...
Bother for big brotherJan 9, 2006 Telegraph.co.uk, ...then beat me. When we rode out for Nigel Twiston-Davies he was always the one that looked like Cash Asmussen.". Michael's debut is ...
Tendon injuries prove an Achilles heel for trainersJan 10, 2006 Unison.ie, ...jointly own the horse, opted last autumn for stem-cell treatment that worked for some high-profile French jumpers and has also got Nigel Twiston-Davies' chaser ...
EYECATCHER OF THE DAY:Dec 31, 2005 Sportinglife.com, The Nigel Twiston-Davies-trained gelding was given a patient ride by Carl Llewellyn before taking control four out in the beginners' chase over three and a ...
Ollie could have layers in a right mess in King GeorgeDec 22, 2005 The Herald, Of course, one man who could help us in this aspect is Nigel Twiston-Davies, who trains Ollie Magern, and he believes that there is no reason why his boy ...
McCoy on Impek as Murphy misses outDec 21, 2005 Times Online, Monkerhostin is on target for the race and will be ridden by Richard Johnson, while Nigel Twiston-Davies reported that Ollie Magern, who suffers from ...
Good ground at SandownDec 22, 2005 Ireland Online, Nigel Twiston-Davies sees no reason why Ollie Magern cannot return to his best form in the extended three-mile contest at the Esher venue. ...
PUT FAITH IN MAGERN MAGICDec 23, 2005 Sportinglife.com, Nigel Twiston-Davies' seven-year-old returned from injury in the best possible way by defeating Kingscliff in the Charlie Hall at Wetherby with a brilliant ...
Cheltenham plans guide Phillips out of shadowsDec 30, 2005 Times Online, Nigel Twiston-Davies, who runs The Cool Guy in the Challow, suffered some disappointments over Christmas with Ollie Magern and Fundamentalist but yesterday ...
Results from yesterday's three meetingsJan 6, 2006 Times Online, 7-2 fav). 16 ran. 1l, 1l. N Twiston-Davies. Tote: £5.00; £1.50, £2.60, £1.90. Exacta: £70.90. CSF: £45.62. 2.20 (3m 110yd ...
Racing: Rhinestone Cowboy doubtul for stayers' eventJan 6, 2006 Independent, Nigel Twiston-Davies is hoping for an improved showing from Fundamentalist when he tackles the Victor Chandler Chase at Cheltenham on 28 January. ...
PUNTERS IN CLIFF PLUNGEDec 23, 2005 Glasgow Daily Record, ..."I don't think the ground will be a problem.". Nigel Twiston-Davies sees no reason why Ollie Magern can't return to his best form in the King George. ...
Cowboy 50-50 for CheltenhamJan 6, 2006 Unison.ie, NIGEL TWISTON-Davies is hoping for an improved showing from Fundamentalist when he tackles the Victor Chandler Chase at Cheltenham on January 28. ...
Chase kings renew battle of Boxing DayDec 23, 2005 Financial Times, ...who was second in the Hennessy. Nigel Twiston-Davies contests with former star novice Ollie Magern. Henrietta Knight, who won the ...
GERAGHTY FULL OF HOPEDec 23, 2005 Sportinglife.com, Completing the line-up are Charlie Hall Chase winner Ollie Magern, trained by Nigel Twiston-Davies, and Irish Hussar from Nicky Henderson's stable.
REBEL WITH A CAUSEDec 26, 2005 Sportinglife.com, Other interesting runners include last year's second Strong Resolve from Lucinda Russell's Kinross stable and the Nigel Twiston-Davies-trained Shardam, who has ...
JOHNSON FACING KNIGHT DILEMMADec 26, 2005 Sportinglife.com, ...runners include last year's second Strong Resolve from Lucinda Russell's Kinross stable, Peter Bowen's McKelvey and the Nigel Twiston-Davies-trained Shardam ...
Brave Inca 5-1 for ChampionDec 29, 2005 Telegraph.co.uk, Nigel Twiston-Davies has confirmed that he has retired the 2002 Grand National winner Bindaree because a small hind-leg problem was interfering with his ...
CLASSY CHALLOWDec 30, 2005 Sportinglife.com, Nicky Henderson runs his Punchestown Festival bumper winner Its A Dream, who easily landed his recent debut over hurdles, while Nigel Twiston-Davies' The Cool ...
Drever heads Walk fieldDec 22, 2005 Ireland Online, ...possibles include Nicholls’ Le Duc, the Alan King-trained pair of Crystal D’Ainay and My Way De Solzen, as well as Nigel Twiston-Davies’ Mistanoora.
Johnson back to winning ways at TauntonDec 30, 2005 Ireland Online, ...in the second division of the novice hurdle when Loita Hills failed by four lengths to hold 7-1 chance Prestbury Knight, trained by Nigel Twiston-Davies and ...
Results from yesterday's two meetingsDec 30, 2005 Times Online, 6-1). 9 ran. NR: Pirate Flagship. 4l, 2l. N Twiston-Davies. Tote: £6.60; £2.20, £1.10, £1.70. Exacta: £17.60. CSF: £16.06.
All systems go for MoscowDec 22, 2005 IrishExaminer.com, ...notable possibles include Nicholls' Le Duc, the Alan King-trained pair of Crystal D'Ainay and My Way De Solzen, as well as Nigel Twiston-Davies' Mistanoora.
Kicking King back to his very bestDec 22, 2005 Kildare Nationalist, Nigel Twiston-Davies has had his string in excellent form and says “There’s no injury to Ollie. He was lame after Haydock but he’s perfectly sound now. ...
Racing: Solzen does it his wayDec 28, 2005 ic Wales, Nigel Twiston-Davies pulled off one of the training feats of the season to saddle Lord Maizey to repeat his 2003 triumph in the At The Races Red Betting ...
Inside the World of RacingDec 23, 2005 Waterford News, The Henrietta Knight trained Impek and Nigel Twiston Davies trained Ollie Magern are both on course for a tilt at the King George V1 Chase on St Stephens Day. ...
Equine farewells of 2005Dec 28, 2005 Horse & Hound Online, The only horse to win the Aintree, Scottish and Welsh Grand Nationals, Earth Summit was trained by Nigel Twiston-Davies and Peter Scudamore. ...
Fighting fit Seychellois returnsDec 30, 2005 Scotsman, Boychuk's credentials are hard to argue with but we may have still to see the best of The Cool Guy so Nigel Twiston-Davies's runner gets the vote while Le Duc ...
River among Chandler entriesDec 22, 2005 RTE.ie, ...entries include Paul Nicholls Kauto Star, Isio from the Nicky Henderson yard and one of last year's top novices Fundemantalist, trained by Nigel Twiston-Davies ...
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