|
Candoxatril
resources
DRUG INFO
Candoxatril
Drug Name:
Candoxatril
|
|
|
Indication: For treatment of hypertension, improve exercise capacity in patients with CHF receiving angiotensin converting enzyme inhibition.
Pharmacology: Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure in man.
Mechanism Of Action: Neutral endopeptidase inhibitors such as Candoxatril have a dual mechanism of action. They inhibit two metalloprotease enzymes, neutral endopeptidase and ACE, resulting in an increased availability of natriuretic peptides that exhibit vasodilatory effects and, possibly, tissue protective effects.
Drug Category: Prodrugs; Antihypertensive Agents; ATC:C02K
Brand Names/Synonyms: Candoxatril; Candoxatrilat
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: 4-[1-[2-(2,3-dihydro-1H-inden-5-yloxycarbonyl)-3-(2-methoxyethoxy)propyl]cyclopentyl]carbonylaminocyclohexane-1-carboxylicacid
Chemical Formula: C29H41NO7
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00027
CAS Registry Number: 118785-03-8
| | |
