Pharmacology: Candesartan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Unlike the angiotensin receptor antagonist losartan, Candesartan does not have an active metabolite or possess uricosuric effects.
Mechanism Of Action: Candesartan competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance.
Drug Category: Antihypertensive Agents; Angiotensin II Receptor Antagonists; ATC:C09CA06
Interactions:
DrugBank: Interactions for Candesartan
Interactions for Candesartan:
No significant drug interactions have been reported in studies of candesartan cilexetil given with other drugs
such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide, and oral contraceptives in healthy volunteers,
or given with enalapril to patients with heart failure (NYHA class II and III). Because candesartan is not
significantly metabolized by the cytochrome P450 system and at therapeutic concentrations has no effects on P450
enzymes, interactions with drugs that inhibit or are metabolized by those enzymes would not be expected.
Lithiumó Reversible increases in serum lithium concentrations and toxicity have been reported during
concomitant administration of lithium with ACE inhibitors, and with some angiotensin II receptor antagonists. An
increase in serum lithium concentration has been reported during concomitant administration of lithium with ATACAND,
so careful monitoring of serum lithium levels is recommended during concomitant use.
Chemical IUPAC Name: 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-benzoimidazole-4-carboxylicacid
Chemical Formula: C24H20N6O3
Half Life: 9 hours
Drug Type: Approved Drug
# Accession No: APRD00420
CAS Registry Number: 139481-59-7
Candesartan News (When available)
Kidney Trouble Speeds Heart FailureFeb 6, 2006 ...study finds. Researchers analyzed data on 2,680 North American patients who took part in a study involving the drug candesartan. "We ... - Forbes
Music, Healing Touch May Aid RecoveryJan 16, 2006 New analysis of a major heart failure study demonstrates that patients treated with Atacand (candesartan) to lower blood pressure reported greater improvement ... - Saturday Evening Post,
D for ‘dud’Jan 12, 2006 People's Weekly World For one volunteer in our organization that means her Atacand (for high blood pressure) and Nexium (acid reflux) will not be available to her. ...
Adherence alone cuts heart failure mortalityDec 13, 2005 AustralianDoctor.com (subscription), ...more than 80% of the time experienced a 35% reduction in all-cause mortality, regardless of whether that medication was candesartan (Atacand) or placebo ...
AstraZeneca keeps medicine chest stockedJan 4, 2006 The News Journal, Co. Sales of Crestor reached $908 million in 2004. It also licenses Atacand, sales of which were $879 million in 2004. Two notable ...
