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Calcitonin, salmon
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DRUG INFO
Calcitonin, salmon
Drug Name:
Calcitonin, salmon
Indication: For treatment of post-menopausal osteoporosis
Pharmacology: Calcitonin inhibits bone removal by osteoclasts (bone remodeling cells) and promotes bone formation by osteoblasts. This leads to a net increase in bone mass. Calcitonin also reduces plasma calcium levels and enhances secretion of ions in the kidney.
Mechanism Of Action: Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) which then enhances the production of vitamin D producing enzymes (25-hydroxyvitamine D-24-hydroxylase), leading to greater calcium retention and enhanced bone density. Binding of calcitonin to its receptor also activates adenylyl cyclase and the phosphatidyl-inositol-calcium pathway.
Drug Category: Antihypocaclemic Agents; Antiosteporotic Agents
Brand Names/Synonyms: Calcitonin 1 precursor; Miacalcin (Novartis)
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Salmon calcitonin
Chemical Formula: C145H241N43O49S2
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: BIOD00025
CAS Registry Number: 12/9/9007
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Calcitonin, salmon News
(When available)
FDA OKs First IV Osteoporosis Drug Jan 13, 2006
WebMD There are other types of osteoporosis drugs. Fortical and Miacalcin are made from a hormone called calcitonin and delivered by nasal spray. ...
US Federal District Court in Indianapolis Rules in Emisphere's ... Jan 9, 2006
Yahoo! News (press release) Emisphere and its partners have advanced oral formulations or prototypes of salmon calcitonin, heparin, insulin, parathyroid hormone, human growth hormone and ...
Unilateral Hyperechoic Renal Pyramids in a Child With Renal Artery ... Jan 5, 2006
Journal of Ultrasound in Medicine ...persists throughout childhood. 11 This abnormality of the calcium metabolism has been attributed to a deficiency in calcitonin. 12 We ...
... Go to the Article Jan 4, 2006
CancerWise ...break down bone. Miacalcin® (calcitonin) is a nasal spray that works in a similar fashion, but may not be as effective. Sellin says ...
FDA OKs First IV Osteoporosis Drug Jan 13, 2006
WebMD There are other types of osteoporosis drugs. Fortical and Miacalcin are made from a hormone called calcitonin and delivered by nasal spray. ...
... Go to the Article Jan 4, 2006
CancerWise ...break down bone. Miacalcin® (calcitonin) is a nasal spray that works in a similar fashion, but may not be as effective. Sellin says ...
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