Indication: For short-term treatment of insomnia and anxiety disorders
Pharmacology: Butabarbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
Mechanism Of Action: Butabarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.
Drug Category: Anti-anxiety Agents; Hypnotics and Sedatives; Barbiturates; ATC:N05CA
Interactions:
DrugBank: Interactions for Butabarbital
Interactions for Butabarbital:
Interactions may occur with the following: adrenocorticoids (cortisone-like
medicine), anticoagulants (blood thinners), carbamazepine, corticotropin (barbiturates may decrease the effects of
these medicines), central nervous system (CNS) depressants (using these medicines with barbiturates may result in
increased CNS depressant effects), divalproex sodium, valproic acid (using these medicines with barbiturates may
change the amount of either medicine that you need to take), and oral contraceptives containing estrogens
(barbiturates may decrease the effectiveness of these oral contraceptives, and you may need to change to a different
type of birth control).
Chemical IUPAC Name: 5-ethyl-5-(1-methylpropyl)hexahydropyrimidine-2,4,6-trione
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