Indication: For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.
Pharmacology: Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Mechanism Of Action: Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Drug Category: Antineoplastic Agents; Immunosuppressive Agents; Alkylating Agents; ATC:L01AB01
Absorption: Completely absorbed from the gastrointestinal tract.
Interactions:
DrugBank: Interactions for Busulfan
Interactions for Busulfan:
Itraconazole decreases busulfan clearance by up to 25%, and may produce AUCs > 1500 µM·min in some
patients. Fluconazole, and the 5-HT3 antiemetics odansetron (Zofran) and granisetron (Kytril) have all been used with
BUSULFEX.
Phenytoin increases the clearance of busulfan by 15% or more, possibly due to the induction of
glutathione-S-transferase. Since the pharmacokinetics of BUSULFEX were studied in patients treated with phenytoin,
the clearance of BUSULFEX at the recommended dose may be lower and exposure (AUC) higher in patients not treated with
phenytoin. Because busulfan is eliminated from the body via conjugation with glutathione, use of acetaminophen prior
to (<72 hours) or concurrent with BUSULFEX may result in reduced busulfan clearance based upon the known property
of acetaminophen to decrease glutathione levels in the blood and tissues.
Chemical IUPAC Name: 1,4-bis(methylsulfonyloxy)butane
Protein Design Labs Becomes PDL BioPharmaJan 9, 2006 PR Newswire (press release), ...of hypertension when oral therapy is not feasible or desirable, Retavase(R) (reteplase) for acute myocardial infarction (AMI), and IV Busulfex(R) (busulfan), a ...
Exploring The Alternatives16 Jan 2006 Saturday Evening Post, One form of chelation therapy, EDTA (ethylenediamine tetra-acetic acid)--a synthetic, or man-made, amino acid--is delivered intravenously and, as practiced in ...
Excise Duty On Bottled Water Squeezes Keringet's Margins16 Jan 2006 AllAfrica.com, ...bottled water. The juice market is a crowded field with local and imported brands, tetra-packed juices and the fresh products. Besides ...
Blade stock contest in full swing16 Jan 2006 Toledo Blade, Diane Jacobson, 60, of Findlay, chose an eclectic portfolio consisting of Gamestop Corp., a video and entertainment-software firm; Tetra Technologies Inc., an ...
TETRA TECHNOLOGIES: Announces 2006 Earnings GuidanceJan 9, 2006 Webbolt Business News (subscription), By MM - Webbolt Newsroom. TETRA Technologies, Inc. ... The low end of the range approximately doubles analysts' current estimates of TETRA's 2005 earnings. ...
EADS signs three major contracts for delivery of TETRA terminalsJan 9, 2006 noticias.info, .../noticias.info/ EADS has received three major contracts delivering its TETRA secure communications terminals to the Belgian fire brigades, to the Irish police ...
Tetra Tech gets deals worth up to $88.5MJan 5, 2006 BusinessWeek 5 4:16 PM ET Tetra Tech Inc., a provider of environmental cleanup services, management and consulting, said Thursday it received two contracts worth a total of ...
Tetra Technologies upgraded to "buy"Jan 6, 2006 New Ratings NEW YORK, January 6 (newratings.com) – Analyst Martin W Malloy of Hibernia Southcoast Capital upgrades Tetra Technologies Inc (TTI.NYS) from "hold" to "buy ...
TETRA Technologies, Inc. Announces 2006 Earnings GuidanceJan 5, 2006 Business Wire (press release), 5, 2006--TETRA Technologies, Inc. (TETRA or the Company) (NYSE:TTI) today announced earnings guidelines for 2006 of $2.09 - $2.35 per diluted share. ...
Tetra Tech Awarded $48.5 Million US EPA START Region 4 ContractJan 5, 2006 Finanzen.net, Tetra Tech, Inc. ... We are very pleased that EPAselected Tetra Tech again to lead the critical Region 4 START programas we have done during the past 10 years. ...
Tetra Tech awarded $48.5 Million US EPA START Region 4 contractJan 6, 2006 Construction and Maintenance News, Tetra Tech, Inc. ... Under the previous contract, Tetra Tech continues to support EPA by performing hurricane response work in the Gulf Coast region. ...
Motorola, T-Systems, R&S deploy TETRA in HamburgJan 5, 2006 Telecom Paper (subscription), The network is based on the mobile radio standard TETRA. As one of the first deployments, the partners will cover Hamburg with a ...
Interxion hosts MCCN TETRA networkDec 20, 2005 Telecom Paper (subscription), ...has chosen the provider of carrier-neutral data centre and managed services in Europe, Interxion, to host the switching and management hub of its TETRA network ...
Tetra Tech Gets Deals Worth Up to $88.5MJan 5, 2006 MSN Money PASADENA, Calif. (AP) - Tetra Tech Inc., a ... The new contract combines an existing contract Tetra Tech has had with the agency for years, the company said. ...
Tetra Tech Gets Deals Worth Up to $88.5M (AP)Jan 5, 2006 Schaeffers Research, Tetra Tech Inc., a provider of environmental cleanup services, management and consulting, said Thursday it received two contracts worth a total of up to $88.5 ...
Residents are wise to voice phone mast fearsJan 13, 2006 Hampstead and Highgate Express, Sir William Stewart in his two reports on mobile phone masts, and TETRA have repeatedly recommended a precautionary approach and further research, but in over ...
Blacksburg firm sues fish supply firm in Fla.Jan 4, 2006 Roanoke Times, Tetra Holding Inc. of Blacksburg ... of Dania, Fla., for $200,942.72, the full amount Tetra claims it is owed for the products. Tetra's Blacksburg ...
Sepura wins 'Stage One' Security Approval in UKJan 10, 2006 Telecom Paper (subscription), Sepura radios are the first and only TETRA radios so far in the United Kingdom to be awarded 'Stage One' Security Approval by the UK Government's ...
Angry OAPs lose TV signalJan 12, 2006 Exmouth Journal, They say interference problems began in the autumn - around the same time the police switched to a new Tetra digital radio system.
Group to assess risks of pylons and radiationJan 11, 2006 Edinburgh Evening News, ...to meet to discuss the risk to public health of electricity pylons and other radiation-emitting sources such as the new generation of Tetra communication masts ...
Amul may witness 50% increase in exportsJan 13, 2006 Sify, ...countries during the year. The product range includes butter, cheese, srikhand, gulab-jamuns, paneer and tetra pack milk. Ice-creams are ...
Find Out The Truth About Oral Chelation TherapyJan 5, 2006 PR Web (press release), This is accomplished by administering an amino acid, ethylene-diamine-tetra-acetic acid (EDTA), by an intravenous infusion using a small 25-gauge needle. ...
Contracted service costs too much, official saysJan 5, 2006 The Grand Rapids Press, ...the city is "spending more money (rather) than less money" for contracted treatment plant operations, Bowers voted against extending Tetra Tech MPS's pact ...
Sweet Success to initiate production of Powerblend beverageJan 12, 2006 Food Ingredients First (press release), ...in Savannah, GA. Powerblend will come packaged in 330ml (11 ounce) aseptic Tetra Prisma containers packaged as four-packs. It is ...
So many SamsJan 13, 2006 Indian Express, He first founded the Tetra Society, which recruits technically-skilled volunteers to contrive assistive devices for disabled people. ...
What to do instead of detoxJan 2, 2006 ic Wales, ...some cold meats to throw together at lunchtime. And make smoothies at weekends rather than drinking squash or Tetra-packed juices.
Friendly Bacteria at WorkJan 1, 2006 Natural Life, A group of 181 workers at a Tetra Pak factory in Lund, Sweden were randomly assigned to receive a drink with or without L. reuteri, every day for a period of ...
Review of the Year: Part II (May-August)Dec 28, 2005 Siliconrepublic.com, The Garda SÃochána signalled its intentions to move into the world of Tetra (Terrestrial Trunked Radio) and issued a tender for 100, rising to possibly 150 ...
Sepura signs partnership with BESCom ElektronikDec 22, 2005 Telecom Paper (subscription), UK-based TETRA radio supplier Sepura has signed a partnership agreement with German systems integrator BESCom Elektronik. BESCom ...
45 and Counting: Turn up the volumeDec 27, 2005 Fauquier Times-Democrat, Tetra Nova, a rock band featuring RJ Haynes, Zack Hale, Doug Sherman and Brian Brower, ushered in the crowd. Haynes is well-known to the Liberty community. ...
Updates, advisories and surprisesJan 5, 2006 Investor's Business Daily (subscription) The stock closed Wednesday at $51.63, down 19 cents. Tetra Tech sees 2006 earns above Wall St. view (8:53 AM ET) NEW YORK (MarketWatch ...
The Winchester StarJan 11, 2006 Winchester Star, Tetra Partnerships, a Reston-based real estate and development company, has purchased commercial real estate property in the industrial park, Barker said. ...
Experts say dust plumes at mine caused by more than windJan 12, 2006 Reno Gazette Journal, Elaborating on some interesting findings so far, Douglas Herlocker, environmental scientist/senior air quality specialist of Tetra Tech EM, Inc., spoke during ...
Cloning MilestonesJan 10, 2006 Fact Monster, 1999 Dr. Gerald Schatten (US) leads a team of researchers who become the first to create a clone (Tetra, a rhesus monkey) by embryo splitting. ...
Amul ready to take on Pepsi, Coke in sports drink segmentJan 10, 2006 Financial Express, With lemon flavour, it will be available in Tetra Paks and is priced at Rs 12(for 200 ml). Two years ago, we entered flavoured milk segment,"said Mr Sodhi. ...
Noga plans new unit in food parkJan 1, 2006 Business Standard, Two years ago, MAIDC had acquired three acres of land for setting up a tetra pack unit in the food park. The plan was, however, shelved ...
Council sets hearing on utility rate hikesJan 12, 2006 Ann Arbor News, As Chelsea prepares to expand its wastewater treatment plant, Tetra Tech MPS was unanimously chosen Tuesday night by the Chelsea City Council to prepare ...
Inmarko fully placed primary bond issue.Dec 23, 2005 Analytical Information Agency, Inmarko ice cream is manufactured under high-end European technologies using state-of-the-art equipment of GRAM, Tetra Pak, APV, GEA. ...
Backwash storage tank project moving along in MCDec 21, 2005 New Baltimore Voice Newspapers, ..."Construction is underway, the steel sheeting is in place, it's temporary, the excavation is complete,“ said Ken Kingsley of Tetra Tech MPS, the project ...
Preview: People in PlanesDec 21, 2005 ic Wales, FRESH from touring the UK with The Crimea and America with The Bravery, local heroes People In Planes (formerly known as Tetra Splendour) are back in Clwb Ifor ...
Stocks Tread Water Despite Jump In VolumeJan 3, 2006 Investor's Business Daily (subscription) ...from $50. Other movers in the group included Tetra Technologies (TTI), Oil States International (OIS) and Schlumberger (SLB). The ...
Kenya Switches to Unleaded FuelJan 3, 2006 AllAfrica.com, ...enhancement additives. The refineries previously added tetra-ethyl lead to petrol to improve its anti-knocking capabilities. Under ...
TURIN 2006: FOCUS; AIR SHIELD AND 9,000 SECURITY PERSONNELJan 2, 2006 ansa.it, Communications between the security forces will be guaranteed by the new 'Tetra' system: instead of the old radios, digital devises similar to mobile ...
Death of 5-year-old boy linked to controversial chelation therapyJan 5, 2006 Pittsburgh Post Gazette, In layman's terms, the administration of ethylene diamine tetra-acetate, commonly known as chelation, resulted in a lack of oxygen to the brain as well as ...
Analyst RatingsJan 8, 2006 Asbury Park Press, StealthGas Inc. (GASS) was rated new "outperform" in new coverage by analyst J. Michael Drickamer at Morgan Keegan. Tetra Technologies Inc. ...
New drinks review: a colorful approach to cocktail presentationJan 3, 2006 Drinks Business Review The punch comes in a compact package design so that it can be easily stored and which is microwave safe. It also has a resealable quick-peel Tetra top. ...
Playground SafetyJan 4, 2006 Child Care Business Magazine, A number of material choices are available in today’s market, including Teflon-coated fiberglass or PTFE, Hybrid forms of PTFE, Ethylene tetra ethylene (ETFE ...
Rockabilly non-revivalJan 6, 2006 Jerusalem Post, When Bill Flag was working on his seminal Tetra Records sessions in 1955 and 1956, he named the style "rockabilly," and the name stuck. ...
The Legend of Zelda: The Wind WakerJan 6, 2006 IGN, Take that PigDemon!) the pirates on the island help you out to go rescue your sister. It seems Link has another girlfriend, Tetra. ...
Rasna Juc FitJan 6, 2006 Chennai Online, ...build a brand. The 200 ml tetra pack of Rasna Juc Fit will be available for Rs 10 while the one litre pack comes at Rs 45. Rasna Pvt ...
Fitness in's and out'sDec 31, 2005 INQ7.net, ...from the production process, packaging and others. The multinational Tetra Pak has set up collection. points in a growing number of ...
Remember the three Rs during the holidays: council appealDec 29, 2005 Meath Chronicle, ...are in Navan and Trim, where householders can bring a wide range of materials including Christmas cards, Christmas trees, wrapping paper, Tetra Pak cartons ...
Laois people urged to do their bit to have a greener ChristmasDec 22, 2005 Laois Nationalist, ...visit the civic amenity site at Kyletalesha Landfill in Portlaoise - where everything from plastic bottles, aluminium cans, cardboard, glass and Tetra Pak can ...
Peak of the Market soups ready for store shelvesDec 19, 2005 Brandon Sun, But for now, the $3.99 soups — sold in one-litre tetra packs — are available in Winnipeg at Dakota Family Foods, Lorenzo’s Speciality Foods, the three ...
APPMA Announces Top Six Pet Industry Trends for '06Dec 28, 2005 Business Wire (press release), Inc. (formerly Rayovac Corp.) recently acquired Tetra, a privately held fish product supplier; Central Garden & Pet Co. purchased ...
Tour de grottoDec 22, 2005 San Antonio Current, Today, only goldfish and Tetra swim around in the pool, but I can identify with that prankster urge. Around the back of the grotto, there's an empty niche. ...
Developer deal surprises DeltonansDec 24, 2005 Orlando Sentinel, Andrew Woodcock, a project manager for Tetra Tech, a consultant to the city, said someone at the city -- he wasn't sure whether it was Behring -- authorized a ...
Opinion Headlines from the Idaho State JournalDec 28, 2005 Idaho State Journal, What a marvelous idea; perhaps the Journal should take the first step and begin publishing a tetra-lingual edition in English, Spanish, Bannock, and Shoshone. ...
Ornamental fish sector enjoying rapid growthDec 19, 2005 Daily Express, ...among the highly sought-after ornamental fish in the world is Arowana, as for Asia, the Gold Fish and Koi, while Europeans are keen on Tetra, Cychlids and Guppy ...
The Literator: heroes and villainsDec 22, 2005 Independent, ...marching orders from HarperCollins when it closed the Flamingo list, Gwyn Jones had set up his own Portobello Books, backed by the Rausings of Tetra Pak fame. ...
Three Sigma firms record turnover of €72mDec 24, 2005 Sunday Business Post, Turnover at SWC rose to €13.3 million from €10.6 million in 2003.The company provides radio communications systems, including the Tetra system used by ...
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