|
Bupropion
resources
|
|
|
|
|
|
DRUG INFO
Bupropion
Drug Name:
Bupropion
Indication: For the treatment of depression and as aid to Smoking cessation.
Pharmacology: Bupropion, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Compared to classical tricyclic antidepressants, Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotonin, and dopamine. In addition, Bupropion does not inhibit monoamine oxidase. Bupropion produces dose-related central nervous system (CNS) stimulant effects in animals, as evidenced by increased locomotor activity, increased rates of responding in various schedule-controlled operant behavior tasks, and, at high doses, induction of mild stereotyped behavior.
Mechanism Of Action: Bupropion selectively inhibits the neuronal reuptake of dopamine, norepinephrine, and serotonin; actions on dopaminergic systems are more significant than imipramine or amitriptyline whereas the blockade of norepinephrine and serotonin reuptake at the neuronal membrane is weaker for bupropion than for tricyclic antidepressants. The increase in norepinephrine may attenuate nicotine withdrawal symptoms and the increase in dopamine at neuronal sites may reduce nicotine cravings and the urge to smoke. Bupropion exhibits moderate anticholinergic effects.
Drug Category: Antidepressants; Antidepressants; ATC:N07BA02
Brand Names/Synonyms: Bupropion; Bupropion Hcl; Wellbatrin; Wellbutrin; Wellbutrin Sr; Wellbutrin Xl; Zyban
Dosage Forms: immediate and sustained release tablets
Absorption: for sustained release, peak plasma conc. are achieved within 3 hours.
Interactions:
DrugBank: Interactions for Bupropion
Interactions for Bupropion:
Few systemic data have been collected on the metabolism of WELLBUTRIN following concomitant administration with
other drugs or, alternatively, the effect of concomitant administration of WELLBUTRIN on the metabolism of other
drugs.
Because bupropion is extensively metabolized, the coadministration of other drugs may affect its clinical
activity. In vitro studies indicate that bupropion is primarily metabolized to hydroxybupropion by the CYP2B6
isoenzyme. Therefore, the potential exists for a drug interaction between WELLBUTRIN and drugs that affect the CYP2B6
isoenzyme (e.g., orphenadrine and cyclophosphamide). The threohydrobupropion metabolite of bupropion does not appear
to be produced by the cytochrome P450 isoenzymes. The effects of concomitant administration of cimetidine on the
pharmacokinetics of bupropion and its active metabolites were studied in 24 healthy young male volunteers. Following
oral administration of two 150-mg sustained-release tablets with and without 800 mg of cimetidine, the
pharmacokinetics of bupropion and hydroxybupropion were unaffected. However, there were 16% and 32% increases in the
AUC and Cmax, respectively, of the combined moieties of threohydrobupropion and erythrohydrobupropion.
While not systematically studied, certain drugs may induce the metabolism of bupropion (e.g., carbamazepine,
phenobarbital, phenytoin).
Animal data indicated that bupropion may be an inducer of drug-metabolizing enzymes in humans. In one study,
following chronic administration of bupropion, 100 mg 3 times daily to 8 healthy male volunteers for 14 days, there
was no evidence of induction of its own metabolism. Nevertheless, there may be the potential for clinically important
alterations of blood levels of coadministered drugs.
Drugs Metabolized by Cytochrome P450IID6 (CYP2D6): Many drugs, including most antidepressants
(SSRIs, many tricyclics), beta-blockers, antiarrhythmics, and antipsychotics are metabolized by the CYP2D6 isoenzyme.
Although bupropion is not metabolized by this isoenzyme, bupropion and hydroxybupropion are inhibitors of the CYP2D6
isoenzyme in vitro. In a study of 15 male subjects (ages 19 to 35 years) who were extensive metabolizers of the
CYP2D6 isoenzyme, daily doses of bupropion given as 150 mg twice daily followed by a single dose of 50 mg desipramine
increased the Cmax, AUC, and t1/2 of desipramine by an average of approximately 2-, 5- and
2-fold, respectively. The effect was present for at least 7 days after the last dose of bupropion. Concomitant use of
bupropion with other drugs metabolized by CYP2D6 has not been formally studied.
Therefore, co-administration of bupropion with drugs that are metabolized by CYP2D6 isoenzyme including certain
antidepressants (e.g., nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics
(e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g.,
propafenone, flecainide), should be approached with caution and should be initiated at the lower end of the dose
range of the concomitant medication. If bupropion is added to the treatment regimen of a patient already receiving a
drug metabolized by CYP2D6, the need to decrease the dose of the original medication should be considered,
particularly for those concomitant medications with a narrow therapeutic index.
MAO Inhibitors: Studies in animals demonstrate that the acute toxicity of bupropion is
enhanced by the MAO inhibitor phenelzine .
Levodopa and Amantadine: Limited clinical data suggest a higher incidence of adverse experiences in
patients receiving bupropion concurrently with either levodopa or amantadine. Administration of WELLBUTRIN Tablets to
patients receiving either levodopa or amantadine concurrently should be undertaken with caution, using small initial
doses and small gradual dose increases.
Drugs that Lower Seizure Threshold: Concurrent administration of WELLBUTRIN and agents (e.g.,
antipsychotics, other antidepressants, theophylline, systemic steroids, etc.) that lower seizure threshold should be
undertaken only with extreme caution. Low initial dosing and small gradual dose increases should be employed.
Nicotine Transdermal System: .
Alcohol: In post-marketing experience, there have been rare reports of adverse neuropsychiatric
events or reduced alcohol tolerance in patients who were drinking alcohol during treatment with WELLBUTRIN. The
consumption of alcohol during treatment with WELLBUTRIN should be minimized or avoided (also see CONTRAINDICATIONS).
Chemical IUPAC Name: 1-(3-chlorophenyl)-2-tert-butylamino-propan-1-one
Chemical Formula: C13H18ClNO
Half Life: 24 hours
Drug Type: Approved Drug
# Accession No: APRD00621
CAS Registry Number: 34841-39-9
|
|
|
|
|
|
Bupropion News
(When available)
Study: Antidepressants pose risks for newborns 09 Feb 2006
These include tricyclics such as amitriptyline sold as Elavil, bupropion sold as Wellbutrin, venlafaxine sold as Effexor and trazodone sold as Desyrel. ... - San Diego Union Tribune,
Smoke Out Doctors Who Neglect Their Smoking Patients (from ... 09 Feb 2006
...the many cessation aids that are now available, including nicotine patches and gum, nicotine inhalers and nasal spray, and medications, such as bupropion. ... - American Council on Science and Health,
2005 - the year of recovery for GSK 09 Feb 2006
...of 2004, in which copycat versions of some of its best sellers, such as the antidepressants Paxil (paroxetine) and Wellbutrin (bupropion), substantially ate ... - Pharma Times (subscription),
OMH adds new smoking cessation workshop Feb 8, 2006
Association.�. Information about tobacco cessation aids such as the nicotine patch and Bupropion (Zyban) will be presented. The ... - Gaylord Herald Times,
Comorbid Tobacco Dependence and Psychiatric Disorders Jan 23, 2006
...combining US Food and Drug Administration-approved pharmacological treatments (nicotine replacement therapies, sustained-release bupropion [Zyban]) with ... - Psychiatric Times,
Biovail Receives Approval for Wellbutrin XL to Treat Depression in ... Jan 17, 2006
Notice of Compliance (NOC) for 150 mg and 300 mg tablet strengths of Wellbutrin® XL, a once-daily, extended-release formulation of bupropion hydrochloride (HCl ... - DG News
International Approvals: Exubera, Kiovig, Wellbutrin XL Jan 30, 2006
Canada's Therapeutic Products Directorate has approved bupropion HCl extended-release tablets for the treatment of major depressive disorder. ... - Medscape (subscription)
Biovail Receives Approval for Wellbutrin(R) XL to Treat Depression ... Jan 17, 2006
Notice of Compliance (NOC) for 150mg and 300mg tablet strengths of Wellbutrin(R) XL, a once-daily, extended-release formulation of bupropion hydrochloride (HCl ... - Business Wire (press release),
Biovail depression drug okayed Jan 17, 2006
...issued a notice of compliance for 150-milligram and 300-milligram tablet strengths of Wellbutrin XL, an extended-release formulation of bupropion hydrochloride ... - Toronto Star,
Kicking the habit Jan 9, 2006
...physical withdrawal symptoms. Bupropion (Zyban) is a non-nicotine prescription antidepressant that helps reduce cravings. These methods ... - Press-Enterprise (subscription),
Attention-Deficit/Hyperactivity Disorder and Substance Use ... Jan 23, 2006
In ADHD adults with SUDs, the nonstimulant agents (atomoxetine [Strattera]), antidepressants (bupropion [Wellbutrin]), and extended-release or longer-acting ... - Psychiatric Times,
Continuity of Antidepressant Treatment for Adults With Depression ... Jan 24, 2006
...paroxetine, fluvoxamine, citalopram, venlafaxine, and venlafaxine extended-release), other newer antidepressants (mirtazapine, bupropion, and nefazodone), or ... - Am J Psychiatry (subscription)
TODAY ON PHARMALIVE.COM Jan 25, 2006
...interdisciplinary program to examine the genetic basis for individual variation in response to nicotine replacement medications and bupropion for treating ... - PharmaLive.com (press release),
The CDC estimates 46.2 million Adults in the US Smoke Cigarettes ... Jan 26, 2006
...available, including many over-the-counter and prescription products for nicotine replacement therapy and the antidepressant bupropion (GlaxoSmithKlines Zyban ... - Business Wire (press release),
Brief Reports: Patterns of Psychotropic Medication Use by Race ... Jan 25, 2006
...amoxapine. Other antidepressants included bupropion, venlafaxine, maprotiline, trazodone, mirtazapine, and nefazodone. Benzodiazepines ... - Psychiatric Services (subscription)
The Stop Smoking Laser Jan 13, 2006
...vaporized form of nicotine through the mouth. Doctors can also prescribe a drug, called bupropion. The medication was originally used as ... - WSOCtv.com,
New Study Shows Hispanics Less Likely to Use Medication to Quit ... Jan 9, 2006
Research has found that the use of the patch, nasal spray or bupropion can double the likelihood of a smoker quitting successfully. ... - HispanicBusiness.com,
Reviewing evidence for effectiveness of gene-based smoking ... Jan 23, 2006
...mainstays of current smoking cessation treatment are nicotine replacement therapy (patches, gum, inhalers, lozenges and spray) and bupropion (Zyban), although ... - RxPG NEWS,
A Reintroduction to Clinical Sexuality Jan 23, 2006
Debattista C, Solvason B, Poirier J, Kendrick E, Loraas E: A placebo-controlled, randomized, double-blind study of adjunctive bupropion sustained release in ... - Focus (subscription)
UPDATE 1-Biovail seeks strict tests for Wellbutrin clones Dec 21, 2005
Reuters ...that it has submitted a "citizen petition" to US regulators seeking strict testing for generic versions of its top-selling antidepressant drug, Wellbutrin XL. ...
Andrx Files Patent Infringement Suit Against GlaxoSmithKline Over ... Dec 21, 2005
Patent Baristas, Andrx Pharmaceuticals has filed a patent infringement suit against the UK's GlaxoSmithKline PLC over a version of the antidepressant Wellbutrin XL. ...
"What questions have disappeared?" Jan 15, 2006
The Common Voice, Prefer "The Matrix" or "You've Got Mail'? Eminem or Sophie B. Hawkins? Been to Ibiza or Cool Britannia? Taking Prozac or Wellbutrin for the depression? ...
At pharmacy, it's Plan Deluge Jan 12, 2006
OregonLive.com, ...caseworker and four with her insurer, he finally was able to establish that the woman owed a $5 co-payment on her prescription for the antidepressant Wellbutrin ...
Suicide Drops With Antidepressant Use Jan 3, 2006
FOX News The 10 drugs identified by the FDA are Prozac, Paxil, Zoloft, Effexor, Celexa, Lexapro, Luvox, Remeron, Serzone, and Wellbutrin. ...
The fool's gold that heals Jan 13, 2006
Guardian Unlimited, GlaxoSmithKline's Zyban for giving up smoking, for example, is a long-acting form of Wellbutrin for depression by another name. ...
A New Year’s Resolution Jan 4, 2006
PR Web (press release), Although medications such as Effexor, Prozac, Paxil, Wellbutrin, Zoloft and Celexa are considered non-addictive, there are many people who describe vast swings ...
Biovail Submits Citizen Petition to FDA Dec 21, 2005
Business Wire (press release), ...of a Citizen Petition with the Food and Drug Administration (FDA) to require rigorous bioequivalence testing for generic products that reference Wellbutrin XL(R ...
Biovail seeks strict testing on some drugs Dec 21, 2005
BusinessWeek ...that it asked the Food and Drug Administration to require "rigorous bioequivalence testing" for generic drugs that refer to its Wellbutrin XL antidepressant. ...
Andrx sues GlaxoSmithKline over drug Dec 20, 2005
BusinessWeek ...said Tuesday it is suing British drug maker GlaxoSmithKline PLC in a federal court for patent infringement over a version of the antidepressant Wellbutrin XL. ...
Business news in brief Dec 21, 2005
Philadelphia Inquirer, Andrx Corp., a generic-drug-maker, said it filed a lawsuit contending one dosage form of GlaxoSmithKline PLC's antidepressant Wellbutrin XL infringes a patent ...
Biovail says citizen petition submitted to FDA Dec 21, 2005
Reuters ...was submitted to US regulators to require rigorous bioequivalence testing for generic products that reference Biovail's Wellbutrin antidepressant before they ...
Andrx Sues GlaxoSmithKline Plc for Infringement of Andrx's Patent ... Dec 20, 2005
Black Enterprise, The Company believes Glaxo's currently marketed formulation of Wellbutrin XL(R) 150mg infringes Andrx Pharmaceuticals, LLC's US Patent No. 6,905,708. ...
Andrx Sues GlaxoSmithKline for Patent Infringement Dec 20, 2005
ag-IP-news Agency, The company believes Glaxo's currently marketed formulation of Wellbutrin XL 150mg infringes Andrx Pharmaceuticals, LLC's US Patent No. ...
GSK sued in patent case Dec 21, 2005
Philadelphia Business Journal, Andrx (NASDAQ: ADRX) of Fort Lauderdale, Fla., said GlaxoSmithKline's currently marketed formulation of 150-mg Wellbutrin XL, an antidepressant, infringes one ...
Andrx sues GlaxoSmithKline Dec 20, 2005
South Florida Business Journal, The Fort Lauderdale-based pharmaceutical company (NASDAQ: ADRX) said Glaxo's currently marketed formulation of 150-mg Wellbutrin XL infringes one of its patents ...
Pill may help avert winter woes Dec 26, 2005
Arizona Republic, ...affective disorder, who had experienced bouts of seasonal depression for an average of 13 years, to take the antidepressant bupropion (Wellbutrin XL) or a ...
Huffing and Puffing Jan 2, 2006
Washington Post, I tried various established methods to help him quit: the antidepressant medication Wellbutrin, which decreases cravings; the nicotine patch; and hypnosis. ...
Spree of burglaries reported on New Year’s weekend Jan 9, 2006
Central Kitsap Reporter, The medications were Wellbutrin and Litium. She told the deputy she couldn’t find anything else missing and her door doesn’t lock. ...
May trial set in Laguna case Jan 10, 2006
Ironwood Daily Globe, Laguna, who had been on the antidepressants since November, was taking Celexa, Wellbutrin, Ceroquel, for schizophrenia, and Xanex. ...
The Down Side of Popping Pills Jan 11, 2006
AlterNet, Wellbutrin, Neurontin, Seroquel, Depakote, Effexor, Inderal, Trileptal, Paxil, Zyprexa, Lamictal, Abilify, I've taken them all. ...
7 days to the best sex ever! Jan 11, 2006
New York Daily News, ...the antidepressant after a year of treatment, Weeks suggested that he consider consulting one again and inquire about the antidepressant Wellbutrin, which is ...
Seasonal Affective Disorder, a Common But Shadowy Condition Dec 29, 2005
MedPage Today, ...scientists are experimenting with other possibilities, including other familiar depression treatments, such as cognitive therapy and Wellbutrin (bupropion). ...
Antidepressants Don't Appear to Raise Suicide Risk, Study Shows Jan 1, 2006
Bloomberg FDA warning were Effexor, Prozac, Pfizer Inc.'s Zoloft, GlaxoSmithKline Plc's Paxil, Solvay SA's Luvox, Biovail Corp.'s Wellbutrin, Forest Laboratories Inc.'s ...
London shares outlook - seen modestly higher ahead of MPC meeting ... Dec 20, 2005
Forbes The suit alleges patent infringement by their current formulation of Wellbutrin XL 150mg. Andrx said the suit seeks treble damages ...
Teen Star Lindsay Lohan Hospitalized After Asthma Attack Jan 5, 2006
MedPage Today, Bulimic patients should not take Wellbutrin (bupropion), she added, because this antidepressant may raise the risk of seizures for these patients. ...
Herb Weisbaum: Some Encouraging News On Treating Depression Jan 5, 2006
KOMO, ...the risk of suicidal behavior was the lowest for patients taking 10 of the newest antidepressant, such as Prozac, Paxil, Zoloft, Celexa, Lexapro, and Wellbutrin ...
Pharmacists get pills out despite drug plan snags Jan 5, 2006
Baltimore Sun, ...enrollment system, which instantly confirmed that Harrison was, in fact, a member, and that his plan covered his prescription for Wellbutrin, an antidepressant ...
Two murders hit county Jan 3, 2006
Ironwood Daily Globe, Laguna, who has been on the antidepressants since November, is currently taking Celexa, Wellbutrin, Ceroquel, for schizophrenia, and Xanex. ...
The Health Report: Ring in the New Year by Understanding Your ... Jan 5, 2006
DeadBrain.us (satire) ..."Vivactil? Vivacious! You are happy and ready to shop, have sex, watch sports. "Wellbutrin, come on, people! You are WELL! Do you hear the word WELL in there? ...
Euroshares outlook - flat post weak US Wall St; Adidas, Puma eyed ... Dec 20, 2005
Forbes Andrx announced last night that it is suing GlaxoSmithKline for patent infringement over the the a formulation of the antidepressent drug Wellbutrin XL 150mg. ...
Depression Weighs Heaviest on the Elderly Dec 31, 2005
PakTribune.com, ...among the elderly: SSRIs (selective serotonin reuptake inhibitors) such as Prozac, Zoloft and Paxil; and the even-newer non-SSRIs such as Wellbutrin and Effexor ...
Business Briefing Dec 21, 2005
Sun-Sentinel.com, Andrx said it believes Glaxo's currently marketed formulation of Wellbutrin XL in the 150-milligram strength infringes an Andrx patent. ...
The Drug Dilemma Dec 28, 2005
ABC7Chicago.com, He or she may lower your dose or put you on a different drug. Wellbutrin and the herb ginkgo biloba may reverse the side effects of some medications.
Quitting smoking just got a little bit easier 16 Jan 2006
Collegiate Times at Virginia Tech, For those who can’t kick the habit quite so easily, there is still hope for successful quitting: Zyban, a new prescription drug. ...
Doctor negligent, says father of overdose victim Jan 15, 2006
Advertiser Adelaide, Shaun Evans, 22, died at the Royal Adelaide Hospital on October 1, 2001, after taking a combination of the quit-smoking drug Zyban and an anti-inflammatory ...
Health and wellness centers help some keep resolutions Jan 13, 2006
The Beam, Sessions two and three begin the drug therapies of Zyban and nicotine patches. Four and five include exercise, nutrition and relaxation training. ...
LABOUR: Free vote on smoking ban Jan 13, 2006
noticias.info, ...wanting to quit, and to give even more help we have made available on the NHS, stop-smoking aids such as nicotine patches and the anti-smoking drug Zyban. ...
Coroner queries patient's drugs Jan 11, 2006
NEWS.com.au, Australian deputy Coroner Tony Schapel has found that Shaun Evans died in 2001 from the combined effects of taking a large quantity of the drug Zyban, given to ...
The fool's gold that heals Jan 13, 2006
Guardian Unlimited, GlaxoSmithKline's Zyban for giving up smoking, for example, is a long-acting form of Wellbutrin for depression by another name. ...
Doctors criticised for delay Jan 12, 2006
Advertiser Adelaide, Shaun Michael Evans, 22, of Walkerville, died after overdosing on more than 100 Zyban tablets, and other anti-inflammatory tablets, he took on the night of ...
It's never too late to make a New Year's resolution to quit ... Jan 11, 2006
Times Herald-Record, One reason for this is if you are planning to use a pharmacotherapy, such as Zyban, you need to see your primary care provider for a prescription and you need ...
Psychiatric patients who smoke Jan 10, 2006
News-Medical.net, ...current smoking cessation treatment are nicotine replacement therapy (patches, gum, inhalers, lozenges and spray) and bupropion (Zyban), although behavioural ...
Smoking Resolution Jan 2, 2006
WNCT, ...do it.". However, he also recommends a pharmaceutical crutch, like Well-Butrin or Zyban. Bupropion is a generic form of Zyban. They ...
Smoking Study Being Conducted In Milwaukee Jan 5, 2006
Milwaukee Channel.com, ...five different medicines or medicine combinations, including the nicotine patch, the nicotine lozenge, combining the patch with the lozenge, Zyban, the pill to ...
Drug May Help People Quit Smoking Dec 21, 2005
WIVB, Shirley Worthington quit smoking last June. Like most smokers, she had tried before, but didn't make it. But she succeeded with a drug called Zyban. ...
Is it true that smoking can give you a saggy bottom and thighs? Dec 22, 2005
Times Online, Another possibility is Zyban bupropion; these are slow-release tablets that alter noradrenaline and dopamine levels in the centres in the brain responsible for ...
UPDATE 1-Pfizer anti-smoking drug to get quick review Dec 21, 2005
Reuters ...last month, varenicline was more effective than GlaxoSmithKline Plc's (GSK.L: Quote, Profile, Research)(GSK.N: Quote, Profile, Research) Zyban at helping ...
Pfizer anti-smoking drug to get quick review Dec 21, 2005
Reuters India, According to data from a late-stage clinical trials released last month, varenicline was more effective than GlaxoSmithKline Plc's Zyban at helping smokers to ...
Resolve to Quit Smoking Dec 29, 2005
Newswise (press release) Smokers can also ask their doctor to prescribe them the drug Buproprian SR (Zyban). Zyban stimulates the release of a feel-good ...
Coroner questions hospital's treatment of patient Jan 11, 2006
ABC Online, He had cut his wrist and told staff he had taken 110 quit smoking tablets known as Zyban. But he failed to tell staff he had also taken anti-inflammatories. ...
Kicking the habit Jan 9, 2006
Press-Enterprise (subscription), ...physical withdrawal symptoms. Bupropion (Zyban) is a non-nicotine prescription antidepressant that helps reduce cravings. These methods ...
Police hunt down cheque forgers Jan 10, 2006
Mmegi, The acting station commander, Howard Modo said the man was recuperating after swallowing 20 Zyban tablets, which were prescribed for smoking. ...
SIXTH ANNUAL REPORT: FUTURE BLOCKBUSTERS Dec 30, 2005
Med Ad News (subscription), ...per day. These patients were given varenicline, GlaxoSmithKline’s marketed Zyban smoking-cessation treatment or a placebo. The ...
New hope for smokers Dec 23, 2005
USA Weekend ...up. And there are non-nicotine methods, including behavior modification and the prescription drug bupropion hydrochloride (Zyban). ...
How To Quit Smoking Dec 30, 2005
WMDT, By STACEY KAISER -- WMDT 12/30/2005. "I've tried the patches, the gum, the lozenges, the medication ZyBan. I've tried it all, the ...
Grant will help Union County step up smoking cessation campaign in ... Jan 1, 2006
Palladium-Item, ...stop the cravings. He hasn't smoked in four months. "I tried cold turkey, I tried Zyban, and I always went back to smoking. I don't ...
Hospitals help smokers kick habit Jan 3, 2006
Ironton Tribune, ...years of quality living.�. The classes are free except for the cost of nicotine replacement or Zyban. Family, friends or other ...
East Valley news briefs Jan 1, 2006
Arizona Republic, ...classes throughout the county, and discounts on nicotine replacement therapy will be available for some participants, including patches, gum, lozenges or Zyban ...
A company's threat: Quit smoking or leave Dec 21, 2005
DetNews.com, After a company-sponsored smoking-cessation program and Zyban, a medication to help quit, the 50-year-old smoked her last cigarette in January 2004. ...
Companies getting tough with employees who smoke Dec 20, 2005
Winston-Salem Journal, After attending a company-sponsored smoking-cessation program and taking Zyban, a medication to help quit, Sutkin smoked her last cigarette in January 2004. ...
Kicking the habit from within Dec 19, 2005
Globes, The company plans to sell Libertal for €150 for the withdrawal period, similar to the price of a treatment with the drug Zyban, and a little higher than ...
|
|
|
