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Brinzolamide
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DRUG INFO
Brinzolamide
Drug Name:
Brinzolamide
Indication: For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Pharmacology: Used in the treatment of glaucoma, brinzolamide inhibits aqueous humor formation and reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss.
Mechanism Of Action: Brinxolamide is both a sulfonamide and a carbonic anhydrase II inhibitor. Carbonic anhydrase catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions, with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure, and thereby a reduction in the risk of optic nerve damage and glaucomatous visual field loss.
Drug Category: Antiglaucomic Agents; Ophthalmics; Carbonic Anhydrase Inhibitors; ATC:S01EC04
Brand Names/Synonyms: Brinzolamide; Azopt; Brinzolamide [USAN]; 2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (R)-; Azopt
Dosage Forms: SUSPENSION
Absorption: Not Available
Interactions: Interactions for Brinzolamide:
AZOPT (brinzolamide ophthalmic suspension) 1% contains a carbonic anhydrase inhibitor. Acid-base and electrolyte alterations were not reported in the clinical trials with brinzolamide. However, in patients treated with oral carbonic anhydrase inhibitors, rare instances of drug interactions have occurred with high-dose salicylate therapy. Therefore, the potential for such drug interaction should be considered in patients receiving AZOPT (brinzolamide ophthalmic suspension) 1%.
Chemical IUPAC Name: 2-ethylamino-4-(3-methoxypropyl)-5,5-dioxo-5$l^{6},7-dithia-4-azabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
Chemical Formula: C12H21N3O5S3
Half Life: 111 days
Drug Type: Approved Drug
# Accession No: APRD00475
CAS Registry Number: 138890-62-7
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Brinzolamide News
(When available)
Christmas tree pickup established at 3 parks Dec 27, 2005
Beaumont Enterprise, Trees stripped of their stands, decorations and any plastics can be left at Rogers Park at Dowlen and Gladys; Sprott Park at Usan and Virginia; and Magnolia ...
Clemson 52, Winthrop 51 Dec 20, 2005
Gainesville Sun, ...usan Yenser's putback in the final second gave Clemson a 52-51 win over Winthrop on Tuesday night. The Lady Tigers (5-6) led 48-37 ...
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