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Bleomycin
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DRUG INFO
Bleomycin
Drug Name:
Bleomycin
Indication: For palliative treatment in the management of the following neoplasms; Malignant neoplasm (trachea, bronchus, lung); Squamous cell carcinoma; Lymphomas
Pharmacology: Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-nonspecific except for Bleomycin (which has major effects in G2 and M phases). Bleomycin is indicated in the palliative treatment of squamous cell carcinoma, lymphomas, testicular carcinoma, alone or in combination with other drugs.
Mechanism Of Action: Although the exact mechanism of action of Bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis.
Drug Category: Antimetabolites; Antibiotics; Antineoplastic Agents; ATC:L01DC01
Brand Names/Synonyms: BLEOMYCIN; BLM; Blenoxane; Bleo; Bleocin; Bleomicin; Bleomicina [INN-Spanish]; Bleomycin (USAN ); Bleomycin sulfate; Bleomycine [INN-French]; Bleomycins; Bleomycinum [INN-Latin]
Dosage Forms: Injection; POWDER FOR SOLUTION
Absorption: systemic absorption approximately 45%
Interactions: [an error occurred while processing this directive]
Chemical IUPAC Name: 3-[[2-[2-[2-[2-[4-[2-[6-amino-2-[1-(2-amino-2-carbamoyl-ethyl)amino-2-carbamoyl-ethyl]-5-methyl-pyrimidin-4-yl]carbonylamino-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino-3-hydroxy-2-methyl-pentanoyl]amino-3-hydroxy-butanoyl]aminoethyl]-1,3-thiazol-4-yl]-1,3-thiazol-4-yl]carbonylamino]propyl-dimethyl-sulfonium
Chemical Formula: C55H84N17O21S3
Half Life: 115 minutes
Drug Type: Approved Drug
# Accession No: APRD00453
CAS Registry Number: 11056-06-7
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Bleomycin News
(When available)
Patients With Unfavorable Risk Hodgkin’s Lymphoma May Not ... Dec 19, 2005
Cancer Consultants (press release), ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) is the most commonly used chemotherapy regimen. BEACOPP (bleomycin, etoposide ...
Patients with Unfavorable Risk Hodgkin’s Lymphoma May Not ... Dec 20, 2005
Cancer Consultants (press release), ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) is the most commonly used chemotherapy regimen for Hodgkin’s lymphoma. ...
PhotoCure ASA - PCI technology enhances effect of anti-cancer drug Dec 5, 2005
Biotech Intelligence (press release), ...journal Clinical Cancer Research, it is now demonstrated that PCI can significantly improve the curative effect of the anti-cancer drug bleomycin in animal ...
Intensive Chemotherapy Regimen Shows Promise for Germ Cell Tumors Dec 5, 2005
Cancer Consultants (press release), This regimen consisted of cycles of cisplatin, vincristine, bleomycin, and carboplatin, followed by one cycle of vincristin and bleomycin and three cycles of ...
Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in ... Dec 9, 2005
Am J Pathology (subscription) The present study examined the pulmonary expression of CCL11 and CCR3 during bleomycin (blm)-induced lung injury and determined their importance in the ...
Plenary Session Snapshot Dec 19, 2005
Medscape (subscription) And, as discussed in the session, the results of chemo-radiation using a limited number of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine), commonly ...
Christmas tree pickup established at 3 parks Dec 27, 2005
Beaumont Enterprise, Trees stripped of their stands, decorations and any plastics can be left at Rogers Park at Dowlen and Gladys; Sprott Park at Usan and Virginia; and Magnolia ...
Clemson 52, Winthrop 51 Dec 20, 2005
Gainesville Sun, ...usan Yenser's putback in the final second gave Clemson a 52-51 win over Winthrop on Tuesday night. The Lady Tigers (5-6) led 48-37 ...
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