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Bivalirudin
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DRUG INFO
Bivalirudin
Drug Name:
Bivalirudin
Indication: For treatment of heparin-induced thrombocytopenia
Pharmacology: Angiomax directly inhibits thrombin by specifically binding both to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Thrombin is a serine proteinase that plays a central role in the thrombotic process, acting to cleave fibrinogen into fibrin monomers and to activate Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently cross-linked framework which stabilizes the thrombus; thrombin also activates Factors V and VIII, promoting further thrombin generation, and activates platelets, stimulating aggregation and granule release
Mechanism Of Action: Inhibits the action of thrombin by binding both to its catalytic site and to its anion-binding exosite.
Drug Category: Anticoagulants; Antithrombotic Agents
Brand Names/Synonyms: Angiomax; Angiomax (Medicines Co or MDCO)
Dosage Forms: Not Available
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: FPRPGGGGNGDFEEIPEEYL
Chemical Formula: C98H138N24O33
Half Life: 25 min (in normal conditions)
Drug Type: Approved Drug
# Accession No: BIOD00076
CAS Registry Number: 128270-60-0
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Bivalirudin News
(When available)
The Medicines Company to Present at the 24th Annual JP Morgan ... Jan 3, 2006
Genetic Engineering News, Clive Meanwell, Chairman and Chief Executive Officer, is expected to discuss company operations, Angiomax(R) (bivalirudin) marketing, and development updates ...
FDA Approvals: Angiomax, Depakote ER, Hylenex Dec 8, 2005
Medscape (subscription) Dec. 8, 2005 — The US Food and Drug Administration (FDA) has approved bivalirudin injection for use in patients with or at risk of heparin-induced ...
The Medicines Company Completes Enrollment of 13,800-Patient ... Dec 7, 2005
Business Wire (press release), This randomized clinical trial is evaluating the direct thrombin inhibitor Angiomax(R) (bivalirudin) replacing heparins (unfractionated heparin or enoxaparin ...
Enrolment of 13,800 patients completed in global trial of Angiox® ... Dec 7, 2005
Biotech Intelligence (press release), This randomised clinical trial evaluates the thrombin-specific anticoagulant Angiox® (bivalirudin) replacing the combination of heparin (either unfractionated ...
The Medicines Company to Present at the 24th Annual JP Morgan ... Jan 3, 2006
Genetic Engineering News, Clive Meanwell, Chairman and Chief Executive Officer, is expected to discuss company operations, Angiomax(R) (bivalirudin) marketing, and development updates ...
IU School of Medicine Partners on Gene Discovery 16 Jan 2006
Inside INdiana Business (press release), Indiana University School of Medicine researchers have led an international team in discovering a gene that causes a rare, inherited and always fatal disorder ...
Medicine endorsed 16 Jan 2006
Advertiser Adelaide, US DOCTORS should prescribe two newer medicines to treat this season's influenza because the dominant strain has become resistant to current drugs, health ...
Sheriffs pushing to get jail medicine requirement changed 16 Jan 2006
In-Forum (subscription), Williams County Sheriff Scott Busching said a law requiring medical training or a nurse's help to give prescription medicine to prisoners "is a pain in the ...
News in medicine 16 Jan 2006
Poughkeepsie Journal, Emergency care in the United States only deserves a C-, according to a new report. The study, conducted by the American College ...
Indiana University School of Medicine Selects MedSeek's SiteMaker ... 16 Jan 2006
Market Wire (press release) ...a leading content management solutions (CMS) provider, announced today the signing of a contract with The Indiana University School of Medicine (IUSM), the ...
Top Universities to Halve Freshmen Intake for Medicine 16 Jan 2006
Chosun Ilbo, ...medical college will face fierce competition this year since Korea¡¯s leading universities are halving their undergraduate intake for medicine starting from ...
Larger Board of Medicine proposed 16 Jan 2006
The Union Leader, CONCORD — The Board of Medicine and other professional regulatory boards could have more members not in their regulated professions under bills proposed by ...
Laughter yoga is a different version of the best medicine 16 Jan 2006
Kingsport Times News, ...and facial muscle strength. It is as integrated medicine and is considered among self-help practices. Laughter yoga classes resume ...
International course on tropical medicine to be held in Havana 16 Jan 2006
Havana Journal This year the 6th edition of the Havana Course in Tropical and Travel Medicine will be held at The Tropical Institute Instituto de medicina Tropical "Pedro ...
An alternative to prescriptions 16 Jan 2006
Fairbanks Daily News-Miner, Dr. Leonie DeRamus exemplifies many of the things alternative medicine is not. She is an MD, board-certified in emergency medicine. ...
Matt Keetley makes 27 saves as Medicine Hat beats Kelowna 4-0 Jan 14, 2006
Calgary Sun, KELOWNA, BC (CP) - Goaltender Matt Keetley made 27 saves and the Medicine Hat Tigers scored three times in the first period en route to a 4-0 victory over the ...
A TASTE OF HIS OWN MEDICINE Jan 15, 2006
New York Post, By DAVID HAFETZ, BRAD HAMILTON and LINDSAY POWERS. The tough guy — at least when it came to his 7-year-old stepdaughter, Nixzmary ...
California starts emergency program to pay for seniors' medicine Jan 13, 2006
San Francisco Chronicle, California will buy prescription drugs for senior citizens and the disabled who cannot get their medicine because of bureaucratic foul-ups under the new ...
California starts emergency program to pay for seniors medicine Jan 12, 2006
San Jose Mercury News, ...as many as 200,000 people eligible for help, California became the largest of at least seven states that have taken emergency measures to get medicine to low ...
Siphoning bear bile for medicine is painless, says China Jan 12, 2006
Times Online, It argued that without a viable substitute, the bile remained an essential ingredient in traditional Chinese medicine and that a campaign launched last year ...
Patients' Genes Can Be Bad Medicine Jan 12, 2006
Forbes ...used by specialists treating cancer or HIV infection," researcher Howard L. McLeod, director of pharmacology at Washington University School of Medicine in St. ...
Medicine Winning the War Against Childhood Blood Cancer Jan 12, 2006
Forbes The report appears in the Jan. 12 issue of the New England Journal of Medicine. The US National Cancer Institute has more about childhood ALL.
Ethiopia, India ink deal to set up tele-medicine, education ... Jan 13, 2006
Monsters and Critics.com, Ethiopian officials signed a three-year agreement Friday with an Indian consultancy firm for the establishment of tele-education and tele-medicine centres in ...
COC packs medicine, has plan in case of Games avian flu outbreak ... Jan 13, 2006
Calgary Sun, ...(CP) - The Canadian Olympic Committee is taking precautions in case there is an avian flu outbreak at next month's Winter Games in Turin, Italy. ...
Dirty Dancing voted top movie medicine Jan 14, 2006
Hindustan Times, The movie Dirty Dancing has been voted the movie women most want to watch when they are ill. According to contactmusic.com, the ...
California Starts Emergency Program To Pay For Seniors Medicine Jan 13, 2006
FoxReno.com, ...as many as 200,000 people eligible for help, California became the largest of at least nine states that have taken emergency measures to get medicine to low ...
State starts emergency program to pay for seniors' medicine Jan 12, 2006
Sacramento Bee, The state of California said Thursday it won't stand by and watch some of its poorest and sickest citizens go without needed medicine. ...
80% of Country Below Average in Emergency Medicine 'Report Card' Jan 13, 2006
Fire Chief, The first-ever National Report Card on the State of Emergency Medicine finds an emergency care system characterized by overcrowding, declining access to care ...
Inhaled Medicine Improves Survival for Lung Transplant Patients Jan 12, 2006
DG News The results of the study are published in the January 12, 2006 edition of the New England Journal of Medicine. The study, which ...
Northwestern Acupuncture and Oriental Medicine Graduation Jan 12, 2006
St. Paul Asian American Press, Ã? The Minnesota College of Acupuncture and Oriental Medicine (MCAOM) at Northwestern Health Sciences University graduated 13 acupuncture and Oriental medicine ...
Sharon's struggle mixes Judaism, modern medicine Jan 9, 2006
Indianapolis Star, By Brian Murphy. JERUSALEM -- Like nearly everything in Israel, Ariel Sharon's condition touches both the hard-edged logic of the ...
Million Dollar Boost for Northern Ontario School of Medicine ... Jan 12, 2006
CNW Telbec (Communiqués de presse), ...announced a $500,000 pledge to the Northern Ontario School of Medicine. ... The Northern Ontario School of Medicine is a pioneering faculty of medicine. ...
Call Kurtis: Emergency Prescription Medicine Plan Jan 12, 2006
CBS 13, ...(CBS 13) SACRAMENTO We're talking about 200,000 Californians struggling to get medicine they desperately need. We received e-mails and calls. ...
Napolitano prescribes state funds for Medicare medicine troubles Jan 13, 2006
Tucson Citizen, Janet Napolitano on Friday declared a potential health crisis and ordered the state to spend up to $500,000 to temporarily help pay for medicine for low-income ...
Judge rejects grazing limits on two Medicine Bow creeks Jan 13, 2006
The Casper Star Tribune, LARAMIE -- A federal court’s rejection of efforts by environmentalists to halt grazing on two creeks in the Medicine Bow National Forest has “huge ...
Roche offers help to local manufacturers to produce HIV medicine ... Jan 12, 2006
SocialFunds.com The model for the transfer of expertise will be based upon the processes to manufacture the HIV protease inhibitor medicine, saquinavir, recommended by the ...
Medicine Winning the War Against Childhood Blood Cancer Jan 12, 2006
WWAY NewsChannel 3, ...at St. Jude, said in a prepared statement. The report appears in the Jan. 12 issue of the New England Journal of Medicine. The US ...
DIRTY DANCING IS ULTIMATE MOVIE MEDICINE Jan 13, 2006
Contactmusic.com, DIRTY DANCING has topped a UK poll as the movie women most want to watch when feeling ill. The smoochy 1987 classic, starring housewife's ...
Motion-sickness medicine joins growing list of recreational drugs Jan 13, 2006
Belleville News-Democrat, Attorney General Lisa Madigan, speaking during a new conference Thursday about a new law that limits sales of cold medicine, said there is always a possibility ...
Skip over-the-counter cough medicine, group advises Jan 13, 2006
Contra Costa Times, ...suggest there's not a lot of justification for using these medications because they haven't been shown to work," said Irwin, a professor of medicine at the ...
Governor promises funding to pay for medicine after confusion from ... Jan 13, 2006
The Eureka Reporter, ...planned, Gov. Arnold Schwarzenegger stepped in late Thursday with a promise of five days’ worth of funding to pay for the medicine.
Kids Vulnerable to Medicine Mishaps Jan 12, 2006
WebMD ...grandparents' pills. Some had gotten the medicines from an open container or purse. Others had been given the medicine by mistake. A wide ...
Medicine And Economics Jan 13, 2006
Harrisonburg Daily News Record, ...are fewer and less expensive. Of course, the classic example of socialized medicine was the former Soviet Union. In 70 years under ...
Medicine Winning the War Against Childhood Blood Cancer Jan 12, 2006
HealthCentral.com THURSDAY, Jan. 12 (HealthDay News) -- Advances in diagnosis and treatment mean that a once deadly childhood blood cancer will soon ...
County unveils discount cards for medicine Jan 13, 2006
Billings Gazette, By TOM HOWARD. Yellowstone County residents could save 15 to 20 percent on the cost of their prescription drugs under a program announced ...
Sharon case pitting medicine, Jewish law Jan 8, 2006
AZ Central.com, JERUSALEM - Like nearly everything in Israel, Ariel Sharon's condition touches both the hard-edged logic of the secular world and the vagaries of faith. ...
Society Of Nuclear Medicine Commends FDA For Release Of New ... Jan 13, 2006
Medical News Today (press release), The Society of Nuclear Medicine commends the Food and Drug Administration's Center for Drug Evaluation and Research, the Center for Biologics Evaluation and ...
Doctors Say Cough Medicine Doesn't Work Jan 12, 2006
KELOLAND TV, Chances are there is cough syrup in your medicine cabinet right now. ... We want to get better fast. 'Give me a medicine that works... now.". ...
Parasites as traditional medicine Jan 14, 2006
Chronicle, Two years back, I discussed the issue of parasites that are used as traditional medicine. ... The medicine helps to control excessive bleeding. ...
Doctor Tasks FG On Traditional Medicine Research Jan 13, 2006
AllAfrica.com, ...need for concrete effort to encourage trado-medical practice, especially to combat the challenges posed by poverty as it applies to accessing modern medicine. ...
Doctors Warn About Giving Cold Medicine to Young Kids Jan 12, 2006
WHOI, Something you give to your kids to help soothe them could end up doing more harm than good. Doctors are warning about over-dosing on cold medicine. ...
Proprietary Chinese medicine recalled Jan 13, 2006
News.gov.hk, Consumers are advised to stop taking a proprietary Chinese medicine called Chi Chun Tang Chu Pai Bo Ying Dan as its microbial content was found to have ...
The Jefferson Award: Beverly Burns, alternative medicine Jan 14, 2006
San Francisco Chronicle, She has a private practice at the Lotus Center in San Francisco and also works at the Osher Center for Integrative Medicine at the University of California at ...
Germany Lacks Bird Flu Medicine Jan 13, 2006
Zaman Online, ...have been taken against the H5N1 strain of bird flu in the country, and in addition no funds have been earmarked for developing an effective medicine to cope ...
Former Mugabe man gets taste of own medicine Jan 13, 2006
ZWNEWS.com, Zvishavane - Zimbabwe police have banned a planned campaign meeting of the country's newest opposition party, the United People's Movement (UPM), giving its ...
New law restricts access to cold, allergy medicine Jan 13, 2006
Chicago Tribune, ILLINOIS -- Cold and allergy medications that can be used to manufacture methamphetamine will be moved behind pharmacy counters Sunday, Atty. Gen. ...
Connecticut receives high marks for emergency medicine Jan 9, 2006
Newsday, By CARA RUBINSKY. HARTFORD, Conn. -- Connecticut's emergency medicine system ranks third in the nation, receiving high marks for patient care and safety but a ...
State gets poor marks for emergency medicine Jan 11, 2006
Seattle Times, When it comes to the state of emergency-medicine systems around the country, there really isn't much good news. At least, that's ...
Traditional Chinese medicine bids for UNESCO heritage Listing Jan 9, 2006
Xinhua, 10 -- The Chinese government is supporting a bid for traditional Chinese medicine to be included on UNESCO's world intangible cultural heritage listing, the ...
Traditional Chinese medicine to apply for cultural heritage Jan 10, 2006
People's Daily Online, China has started the project of applying for the world cultural heritage for its traditional medicine. The plan for the program has drafted recently. ...
Traditional Chinese medicine to apply for cultural heritage Jan 10, 2006
Xinhua, BEIJING, Jan. 11 -- China has started the project of applying for the world cultural heritage for its traditional medicine. The ...
Study Finds University of Medicine and Dentistry of New Jersey ... Jan 10, 2006
New York Times, 10 - The University of Medicine and Dentistry of New Jersey was "undisciplined and careless" in relying too heavily on no-bid contracts in the last fiscal year ...
All in the serve of medicine Jan 9, 2006
Times Online, ...of penicillin and other drugs that changed medical practice for ever; the problem was, how could manufacturers impart knowledge of changing medicine to pill ...
Foot medicine lands Cheney in hospital for shortness of breath Jan 10, 2006
Chicago Tribune, WASHINGTON, DC -- Vice President Dick Cheney's medication for a foot problem caused fluid retention that in turn caused shortness of breath, resulting in a ...
Brown to get a taste of his own medicine after EU rap Jan 11, 2006
Times Online, GORDON BROWN will find the tables turned when he next meets European Union finance ministers, after the European Commission criticised Britain for allowing its ...
258,700 medicine-related cases handled during Jan.- Nov. of 2005 Jan 12, 2006
Xinhua, 12 (Xinhuanet) -- China handled 258,700 medicine-related cases which involved 430 million yuan (around 53.75 million US dollars) in value in the first 11 ...
Connecticut receives high marks for emergency medicine Jan 9, 2006
Boston Globe, By Cara Rubinsky, Associated Press Writer | January 10, 2006. HARTFORD, Conn. --Connecticut's emergency medicine system ranks third in the nation, receiving ...
Cough Medicine Doesn't Work, May Harm Kids Jan 9, 2006
FOX News ...are not useful in children and can actually be harmful,� says Irwin, who is chief of the division of pulmonary, allergy, and critical care medicine at the ...
Centam says trade pact stalled by medicine rules Jan 11, 2006
Reuters AlertNet, By Mica Rosenberg. GUATEMALA CITY, Jan 11 (Reuters) - Implementation of a new US-Central American trade pact could be delayed by ...
InsideStory: Traffickers get a taste of own medicine Jan 8, 2006
Daily Nation (subscription), Arrested at the airport and other key entry points, convicted drug pushers narrate their sobering ordeals at the hands of law enforcers. ...
Sharon felled by medicine side effect Rare consequence of blood ... Jan 5, 2006
San Francisco Chronicle, Israeli Prime Minister Ariel Sharon's massive brain hemorrhage Wednesday appears to be a rare but well-known side effect of blood-thinning medication taken to ...
Connecticut receives high marks for emergency medicine Jan 10, 2006
Stamford Advocate, HARTFORD, Conn. -- Connecticut's emergency medicine system ranks third in the nation, receiving high marks for patient care and safety but a failing grade for ...
State of Emergency Medicine in Tennessee Jan 10, 2006
Bristol Herald Courier, ...based on research released today by The American College of Emergency Physicians in its National Report Card on the State of Emergency Medicine, which handed ...
Alabama ranks No. 41 on national emergency medicine report card Jan 10, 2006
Birmingham Business Journal, The inaugural National Report Card on the State of Emergency Medicine, released by the American College of Emergency Physicians, ranks Alabama 41st out of the ...
US Emergency Medicine Receives "C-" Grade For Emergency Medicine Jan 10, 2006
All Headline News The first-ever National Report Card on the State of Emergency Medicine cites the US emergency care system with overcrowding, declining access to care, soaring ...
Florida emergency medicine scores low on national report card Jan 10, 2006
Tampa Bay Business Journal, The American College of Emergency Physicians' gave Florida an overall grade of C- on the organization's National Report Card on the State of Emergency Medicine ...
Missouri earns C-plus in emergency medicine Jan 10, 2006
Kansas City Star, The American College of Emergency Physicians released its national and state-by-state report cards on emergency medicine Tuesday - and with a reason. ...
South Dakota gets D+ in emergency medicine review Jan 10, 2006
Aberdeen American News, South Dakota lacks an emergency medicine residency program, which could threaten the future supply of emergency doctors, the report said. ...
Doctors say cough medicine doesn't work Jan 9, 2006
United Press International NORTHBROOK, Ill., Jan. 9 (UPI) -- Chest experts say over-the-counter cough syrup doesn't work. The American College of Chest Physicians ...
Physicians' group gives SC B- overall in emergency medicine Jan 10, 2006
WIS, 10, 2006 - The American College of Emergency Physicians is ranking the state of emergency medicine across the nation, and South Carolina passed. ...
The State Of Emergency Medicine Jan 10, 2006
KELOLAND TV, ...is anything but. And a new report card on the state of emergency medicine in the state shows they're right. Today's report card ...
COUGH MEDICINE DOESN'T WORK Jan 9, 2006
Free Market News Network, Consumers spend billions each year on nonprescription cough syrups, drops, and so-called cough and cold medications. But an expert ...
NJ deploys medicine safety net Jan 10, 2006
Newark Star Ledger, BY CAROL ANN CAMPBELL. New Jersey continued yesterday to catch poor, elderly and disabled people falling through holes in the new ...
Cornell's College of Veterinary Medicine Develops Protein Tests to ... Jan 9, 2006
Kansas City infoZine, While dogs keep dying from eating pet food tainted with aflatoxin, Cornell University's College of Veterinary Medicine is announcing it has developed protein ...
Panel: No Evidence To Support Effectiveness Of Cough Medicine Jan 10, 2006
All Headline News Dr. Peter Dicpinigaitis, a panel member, says cough medicine might help some patients, but carry the risk of oversedation, which is especially dangerous to kids ...
You May be Wasting $ Buying OTC Cough Medicine Jan 10, 2006
WLNS, Thinking of taking some over the counter cough syrup to treat your cold? Well, you may want to think again. Many of the nation's ...
Foot medicine shortened Cheney's breath, his office says Jan 9, 2006
Winston-Salem Journal, Medication that Vice President Dick Che-ney was taking for a foot problem caused fluid retention that in turn caused shortness of breath, resulting in a brief ...
US Emergency Medicine System Near Breaking Point Jan 11, 2006
MedPage Today, 11 - The emergency medicine system in the United States, already under stress, could fail if severely tested by a new natural disaster or terrorist attack ...
Endowment to bring lecture series to school of medicine Jan 9, 2006
Greenville Daily Reflector, A new endowed lecture series that honors a pioneering neurosurgeon will bring top medical speakers to the Brody School of Medicine at East Carolina University. ...
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