Indication: For the management of hypertension and prophylaxis treatment of angina pectoris and heart failure
Pharmacology: Bisoprolol is a competitive, beta(1)-selective (cardioselective) adrenergic antagonist. Bisoprolol is used to treat hypertension, arrhythmias, coronary heart disease, glaucoma, and is also used to reduce non-fatal cardiac events in patients with heart failure. Activation of beta(1)-receptors (located mainly in the heart) by epinephrine increases the heart rate and the blood pressure, and the heart consumes more oxygen. Drugs such as Bisoprolol that block these receptors therefore have the reverse effect: they lower the heart rate and blood pressure and hence are used in conditions when the heart itself is deprived of oxygen. They are routinely prescribed in patients with ischemic heart disease. In addition, beta(1)-selective blockers prevent the release of renin, which is a hormone produced by the kidneys which leads to constriction of blood vessels. Bisoprolol is lipophilic and exhibits no intrinsic sympathomimetic activity (ISA) or membrane stabilizing activity.
Mechanism Of Action: Bisoprolol selectively blocks catecholamine stimulation of beta(1)-adrenergic receptors in the heart and vascular smooth muscle. This results in a reduction of heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. Bisoprolol can also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles, causing bronchospasm.
Drug Category: Sympatholytics; Antihypertensive Agents; Adrenergic beta-Antagonists;
Absorption: 80%, not affected by the presence of food
Interactions:
DrugBank: Interactions for Bisoprolol
Interactions for Bisoprolol:
ZEBETA should not be combined with other beta-blocking agents. Patients receiving catecholamine-depleting drugs,
such as reserpine or guanethidine, should be closely monitored, because the added beta-adrenergic blocking action of
ZEBETA may produce excessive reduction of sympathetic activity. In patients receiving concurrent therapy with
clonidine, if therapy is to be discontinued, it is suggested that ZEBETA be discontinued for several days before the
withdrawal of clonidine.
ZEBETA should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain
calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or
antiarrhythmic agents, such as disopyramide, are used concurrently.
Concurrent use of rifampin increases the metabolic clearance of ZEBETA, resulting in a shortened elimination
half-life of ZEBETA. However, initial dose modification is generally not necessary. Pharmacokinetic studies document
no clinically relevant interactions with other agents given concomitantly, including thiazide diuretics, digoxin, and
cimetidine. There was no effect of ZEBETA on prothrombin time in patients on stable doses of warfarin.
Risk of Anaphylactic Reaction: While taking beta-blockers, patients with a history of severe anaphylactic reaction
to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic.
Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions.
Chemical IUPAC Name: 1-[4-[2-(1-methylethoxy)ethoxymethyl]phenoxy]-3-(1-methylethylamino)propan-2-ol
Chemical Formula: C18H31NO4
Half Life: 9-12 hours
Drug Type: Approved Drug
# Accession No: APRD00257
CAS Registry Number: 66722-44-9
Bisoprolol News (When available)
Amiodarone Plus Beta-Blocker Prevents ICD ShocksJan 11, 2006 ...of ICD shocks in 412 patients who were randomized to receive amiodarone plus a beta-blocker (either metoprolol, carvedilol, or bisoprolol), sotalol alone, or a ... - Medscape (subscription)
Mylan Announces Final Approval for Bisoprolol Fumarate Tablets ...Dec 19, 2005 PR Newswire (press release), ...has received final approval from the US Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Bisoprolol Fumarate Tablets USP ...
Business news briefs: 12/20/05Dec 19, 2005 Pittsburgh Post Gazette, Mylan Laboratories received US Food and Drug Administration approval for Bisoprolol Fumarate tablets used to treat high blood pressure. ...
Expect increased volatility15 Jan 2006 Business Standard, Concor, HLL and TCS also appear to have serious downsides in the short-term. HLL and TCS are precariously poised on supports while ...
Railways haulage rates may dip15 Jan 2006 Business Standard, He also said the rate structure would be framed on the lines of what was charged by Container Corporation of India (Concor). To ...
Concor’s dominance over rail container cargo to continueJan 8, 2006 Financial Express, MUMBAI, JAN 8: Concor's monopoly may be over, but its dominance over the rail container cargo will continue, thanks to the eligbility criteria of having rail ...
Rlys to extend Concor`s rent rebate for 2 yearsJan 3, 2006 Business Standard, The Railways have decided to subsidise land rent for Container Corporation of India (Concor) for two more years. This will tilt ...
Concor`s logistics service to take on container policyJan 5, 2006 Business Standard, Container Corporation of India (Concor) will join hands with Central Warehousing Corporation and Pipavava Rail Corporation Ltd to provide complete logistics ...
`Concor has an unfair edge`Jan 6, 2006 Business Standard, This is because the Railways’ own subsidiary, the Container Corporation of India (Concor), is a major player in this area. Indian ...
Private cos need muscle to catch up with ConcorJan 6, 2006 Economic Times, The government’s decision to open up rail container traffic to private players will end Concor’s monopoly in the rail container transport market. ...
Concor to lose monopoly under new container policyJan 5, 2006 Economic Times, NEW DELHI: Container Corporation of India’s (Concor) monopoly over rail-based container business has finally been broken. The ...
Market bullish on ConcorJan 5, 2006 Sify, Despite the announcement of the policy to do away with Container Corporation of India's (Concor) monopoly in container traffic movement on the railway network ...
Railways to extend Concor`s rent rebate for two yearsJan 3, 2006 Myiris.com, The Railways have decided to subsidise land rent for Container Corporation (Q, N,C,F)* of India (Concor) for two more years, reports Business Standard. ...
Concor plans JV for common rail services at JN PortDec 15, 2005 Business Standard, Multi-modal logistics operator Container Corporation of India Ltd (Concor) is planning to team up with Jawaharlal Nehru Port Trust (JNPT), Danish shipping ...
Concor plans terminal expansion at JNPTDec 20, 2005 Business Standard, Multi modal logistics operator Container Corporation of India (Concor) is planning to acquire additional 14 hectares of land to expand its container freight ...
Rail freight corridor details to be unveiled in BudgetJan 12, 2006 Financial Express, The Container Corporation of India (Concor) imports wagons for its operations to supplement those manufactured within the country. ...
Bravo, Laloo!Jan 8, 2006 Economic Times, The Railways’ decision to end Container Corporation of India(Concor)’s effective monopoly and allow private players in container business is welcome. ...
Rail freight tariffs to go down by 40%Jan 9, 2006 Times of India, Railway sources reveal that efforts are being made to eliminate the price distortion created by Concor, which has been encashing its monopoly status by ...
Why India might decide P&O battleJan 14, 2006 The Observer, While DPW runs two terminals in India, one in Kochi in a joint venture with the state-owned Container Corporation of India (Concor) and another in ...
Container cargo movement — Pipavav ready, others to wait and ...Jan 6, 2006 Hindu Business Line, ...sector, players in the industry have started chalking plans to enter into the domain hitherto dominated by the Container Corporation of India Ltd (Concor). ...
Competition on trackJan 8, 2006 Business Standard, Door-to-door container service, which is what they will offer, has so far been the exclusive domain of the Container Corporation of India (Concor), a listed ...
Right On TrackJan 8, 2006 Times of India, ...and foreign, are waiting to enter the containerised transport business, which has so far been the preserve of the Container Corporation of India (CONCOR). ...
Railways open door to private shippersJan 5, 2006 Business Standard, ...off a policy that will allow private companies in container transportation by rail, bringing to an end Container Corporation of India’s (Concor) long-held ...
Railways open door to private shippersJan 5, 2006 Rediff, All companies, including Concor, will now have to pay a one time registration fee of Rs 50 crore to ply on all routes and Rs 10 crore if they want to run on a ...
CCT revises rail container movement proceduresJan 4, 2006 Sify, Rail connectivity for import/export boxes at CCT is handled through Container Corporation of India (Concor) annexe at the Chennai port. ...
Railways on right trackJan 6, 2006 Financial Express, ...and financial, the opening up of one stream of traffic for competition, by ending the long-held monopoly of the Container Corporation of India (Concor) in this ...
Railways to open up freight biz to private firmsJan 5, 2006 India Infoline.com, The move puts an end to Container Corporation of India's (CONCOR) monopoly in the segment. While policy guidelines have been in ...
Foreign players denied berth on container trainJan 6, 2006 Daily News & Analysis, Foreign logistics and shipping companies are currently using the facilities of railway undertaking Container Corporation of India (Concor) for the purpose. ...
Railways throws open container to pvt firmsJan 5, 2006 Times of India, The policy announcement by Railway minister, Lalu Prasad Yadav, puts an end to Railway subsidiary, Container Corporation of India's (Concor) monopoly in the ...
Railways ends monopoly of container train servicesJan 5, 2006 Newindpress, Budget, Laloo Prasad Yadav on Thursday opened the container train services to private players, ending the monopoly of Container Corporation of India (Concor). ...
ASSOCHAM seeks time-bound execution of freight corridor projectJan 7, 2006 India Infoline.com, Welcoming Railway’s decision to permit private container transport companies to compete with CONCOR for moving of goods for both imports and exports, The ...
Reliance has railway cargo plansDec 18, 2005 Business Standard, At present, government-owned multimodal logistics operator Container Corporation of India Ltd (Concor) has monopoly in container freight operations by rail in ...
Ruia, Jaiprakash in race for SK Birla wagon unitDec 16, 2005 Business Standard, Sources in SK Birla group also pointed out that Cimmco was likely to get Rs 20 crore outstanding from Container Corporation (Concor) soon. ...
Railways runs on privatisation trackDec 29, 2005 Times of India, The move puts an end to Railways' subsidiary, Container Corporation of India's (Concor) monopoly in the containerised transport segment. ...
Decatur Lutheran Bible Institute to begin January 31Jan 10, 2006 Decatur Daily Democrat, ..." Creation or Evolution — Which is the Intelligent Choice?" by Mr. Chris-topher Gieschen of Concor-dia Luth-eran High School, Fort Wayne. ...
Paper on pvt sharing in container traffic soonDec 15, 2005 Financial Express, Significantly, the railway ministry had last year allowed Pipavav Rail Corporation Ltd (PRCL) to transport containers by rail, ending Concor’s monopoly in ...
Railways plans to run double-stack containerJan 8, 2006 Sify, ...and the policy of container train movement will be uniformly applicable to all applicants including Container Corporation of India Ltd (CONCOR), he said ...
Private players invited to run rail container servicesJan 5, 2006 Deccan Herald, The process of registration and the policy of container train movement will be uniformly applicable to all applicants including Concor, he said, adding “all ...
JNPT records 9.32 per cent rise in freight traffic in 2005Jan 3, 2006 Business Standard, ...of India Pvt Ltd - managed by a consortium led by Danish shipping giant Maersk Sealand and rail PSU Container Corporation of India (Concor) will start its ...
Docking at port IndiaDec 23, 2005 Financial Express, The Maersk-Concor consortium has been given the contract to redevelop the container terminal at Jawaharlal Nehru Port Trust (JNPT) for Rs 900 crore and P&O has ...
Lalu shows the wayJan 6, 2006 Financial Express, ...operations. The decision ends the monopoly enjoyed by the Indian Railways’ subsidiary, Container Corporation of India (Concor). ...
Shipping Trade Act to check middlemenJan 1, 2006 Business Standard, Joesph said a shipper had the right to know the rationale of the surcharge imposed by an airline or shipping line or even Concor. ...
Domestic container makers upbeatJan 6, 2006 Daily News & Analysis, ...tonnes over the next five years. Concor has been procuring around 1,500 wagons every year. According to Ruia, if private players ...
Company capers for Jan/FebJan 6, 2006 Moneyweb, Schemes of arrangements are likely to be finalised for three companies over the next two months: Assmang (R26 per share), Concor (R28 per share) and Messina ...
Selloff likely in fertiliser PSUsDec 27, 2005 Rediff, These companies include Bharat Sanchar Nigam Ltd, Shipping Corporation of India, Concor, Indian Railways Finance Company, PowerGrid Corporation, Power Finance ...
'Poor warehousing leads to loss in farm produce'Dec 18, 2005 News Today, HD Gujrati, group general manager, CONCOR, Parasuraman R, chairman, CII - southern region, and Ennarasu Karunesan, CEO, Chennai Container Terminal, Chennai ...
India keeps selloff pot boilingDec 12, 2005 Rediff, These PSUs are Container Corporation (Concor), Bharat Sanchar Nigam Ltd, Indian Railways Finance Corporation, Power Finance Corporation, PowerGrid Corporation ...
Funds for Zambezi Bridge Now CompleteDec 14, 2005 AllAfrica.com, The four on the shortlist are the consortia Hochties/CMC/CONCOR, and Mota Engil/Soares da Costa, and two individual Portuguse companies, namely Teixeira Duarte ...
EMCOR Group buys FluidicsJan 12, 2006 Contractor Mag, NORWALK, CONN. — EMCOR Group, the country's largest mechanical contractor, announced Nov. ... Terms of the transaction were not disclosed. EMCOR was ranked No. ...
EMCOR Group, Inc. Announces Recently Awarded $200 Million in ...Jan 10, 2006 New Age Media Concepts (press release) NORWALK, CT, (NAMC) - EMCOR Group, Inc. (NYSE:EME - Profile), a Fortune 500 ... sector commercial work.". EMCOR Group, Inc. is a Fortune ...
EMCOR announces 2-for-1 stock splitDec 15, 2005 Reuters Dec 15 (Reuters) - Emcor Group Inc. (EME.N: Quote, Profile, Research) said on Thursday, its board approved a two-for-one stock split ...
Wolseley secures preferred supplier status with EmcorDec 13, 2005 Contract Journal, Emcor Facilities Management senior buyer Andrew Blackmoor said: "Developing alliances with preferred suppliers is a key element in Emcor's long-term strategic ...
EMCOR: EMCOR Group, Inc. Announces Recently Awarded $200 Million ...Jan 10, 2006 Webbolt Business News (subscription), EMCOR Group, Inc., a Fortune 500® leader in mechanical and electrical construction, energy infrastructure and facilities services for a diverse range of ...
Former Poole & Kent CEO loses quest for legal feesJan 5, 2006 Baltimore Business Journal, Stoffregen had to enter a plea on the criminal charges, he asked Baltimore County Circuit Court judge Robert Dugan to force Poole & Kent parent Emcor to cover ...
Firm's ex-chief accused of fraudJan 6, 2006 Baltimore Sun, ..."Stoffregen, together with confederates, devised and executed a scheme where by they stole more than $1 million from EMCOR and Poole and Kent, and Stoffregen's ...
Small-Cap Stocks in MotionJan 10, 2006 TheStreet.com Emcor Group (EME:NYSE - commentary - research - Cramer's Take) was on the rise after the Norwalk, Conn., construction services company said it was recently ...
People & Awards - McGraw-Hill Construction | ENRJan 4, 2006 Engineering News-Record, Prior to that, he had been president and CEO of EMCOR Group Inc., a mechanical and electrical contracting firm in Greenwich, Conn. ...
MSCA Meeting a Hit, as 20 Receive STAR CertificationJan 10, 2006 Contracting Business Inc., San Jose, CA; Chiller Technology Inc., Burlington, MA; Coleman Spohn Corporation, Cleveland, OH; Comm Air, Inc., South Boston, MA; EMCOR Service/Mesa ...
News For Your Web SiteDec 16, 2005 dBusinessNews Hartford (press release), EMCOR Group, Inc. Announces Two-for-One Stock Split; Special ... Increase in Authorized Shares. Hartford -- EMCOR Group, Inc. (NYSE: EME), a ...
Ascend-Mindanao skills training graduation heldDec 26, 2005 Sun.Star, After the training, they went into industry immersion hosted by MSK Motor Shop, Exodus Cycle Mart, Ride Gear, Emcor Marketing, Guillamac's Marketing, Honda ...
Mylan Announces Final Approval for Bisoprolol Fumarate Tablets ...Dec 19, 2005 PR Newswire (press release), Bisoprolol Fumarate Tablets, which are the AB-rated generic version of Duramed Pharmaceuticals' Zebeta(R) Tablets, 5mg & 10 mg, had US sales of approximately ...
Business news briefs: 12/20/05Dec 19, 2005 Pittsburgh Post Gazette, ...to treat high blood pressure. The drug is the generic version of Duramed Pharmaceuticals' Zebeta. ... William H. Gray III, senior ...
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