Indication: For the treatment of high blood pressure and management of edema
Pharmacology: Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Mechanism Of Action: As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like benzthiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of benzthiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Drug Category: Antihypertensive Agents; Diuretics; Stimulants; ATC:C03AA
Interactions:
DrugBank: Interactions for Benzthiazide
Interactions for Benzthiazide:
Benzthiazide may interact with alcohol, blood thinners, decongestant drugs
(allergy, cold, and sinus medicines), diabetic drugs, lithium, norepinephrine, NSAIDs like Aleve or Ibuprofen, and
high blood pressure medications.
Chemical IUPAC Name: 3-(benzylsulfanylmethyl)-9-chloro-5,5-dioxo-5λ6-thia-2,4-diazabicyclo[4.4.0]deca-3,6,8,10-tetraene-8-sulfonamide
Chemical Formula: C15H14ClN3O4S3
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: APRD00728
CAS Registry Number: 91-33-8
Benzthiazide News (When available)
Millionaires find touch in 4th quarter, down Trojans16 Jan 2006 Chambersburg Public Opinion, ...minutes. Urese Taylor had 11 points and eight rebounds for Chambersburg while Aaron Hill scored eight with six rebounds. Motichka ...
Corralling the MustangsDec 27, 2005 Chambersburg Public Opinion, For the quarter, Chambersburg was eight-for-14 shooting with Aaron Hill, Matt Bosenbark, Armond Perez and Urese Taylor coming off the bench to contribute 11 of ...
Trojans bury CD East with precise shootingDec 21, 2005 Chambersburg Public Opinion, ...just three points. "We had a slew of guys guarding him," Shreffler said, "but Martin Kell and Urese Taylor did especially well.".
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