Pharmacology: Benzonatate, a non-narcotic antitussive agent chemically related to tetracaine and other ester-type local anesthetics, is used to suppress cough associated with both acute and chronic respiratory conditions.
Mechanism Of Action: Benzonatate acts peripherally, anesthetizing the stretch receptors of vagal afferent fibers in the alveoli of the lungs, bronchi, and pleura. When applied locally, Benzonatate binds within the intracellular portion of voltage-gated sodium channels, decreasing the rate of membrane depolarization and increasing the threshold for electrical excitability.
News items from around Southern CaliforniaDec 15, 2005 San Jose Mercury News, A girl and two boys were hospitalized, one in serious condition, after taking the prescription drug Benzonatate Wednesday morning at school. ...
Campus overdose puts 3 in hospitalDec 15, 2005 OCRegister, The overdoses of the prescription cough suppressant benzonatate were reported about 10:25 am Hours later, one of the male students, a 14-year-old, was arrested ...
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