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Alpha-1-proteinase inhibitor
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DRUG INFO
Alpha-1-proteinase inhibitor
Drug Name:
Alpha-1-proteinase inhibitor
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Indication: For treatment of panacinar emphysema
Pharmacology: Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema.
Mechanism Of Action: Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). It primarily inhibits the action of the serine protease called elastase (also plasmin and thrombin). The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Drug Category: Enzyme replacement; enzymes (44:00.00)
Brand Names/Synonyms: Alpha-1-antitrypsin precursor;Alpha-1 protease inhibitor;Alpha-1- antiproteinase; Aralast (Baxter); Prolastin (Talecris Biotherapeutics ¨C formerly Bayer)
Dosage Forms: POWDER FOR SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Alpha-1-proteinase inhibitor
Chemical Formula: C2001H3130N514O601S10
Half Life: Not Available
Drug Type: Approved Drug
# Accession No: BIOD00002
CAS Registry Number: 9041-92-3
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