Indication: For topical treatment of cutaneous lesions in patients with AIDS- related Kaposi sarcomaia.
Pharmacology: Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS- related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.
Mechanism Of Action: Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.
Interactions:
DrugBank: Interactions for Alitretinoin
Interactions for Alitretinoin:
Patients who are applying Panretin® gel should not concurrently use products that contain DEET (N,
N-diethyl-m-toluamide), a common component of insect repellent products. Animal toxicology studies showed increased
DEET toxicity when DEET was included as proof of the formulation. Although there was no clinical evidence in the
vehicle-controlled studies of drug interactions with systemic antiretroviral agents, including protease inhibitors,
macrolide antibiotics, and azole antifungals, the effect of Panretin® gel on the steady-state concentrations of
these drugs is not known. No drug interaction data are available on concomitant administration of Panretin® gel
and systemic anti-KS agents.
Chemical IUPAC Name: 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoicacid
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Light or Heat Treatments as Alternatives to DrugJan 11, 2006 New York Times, And chemical peels and retinoids like adapalene (brand name Differin) and tretinoin (Retin-A) help too, by preventing dead skin cells from clogging pores. ...
Cosmetics tipsDec 21, 2005 Fort Wayne News Sentinel, ...option to address wrinkles and blemishes is the active ingredient tretinoin, found in prescription products such as Renova, Tazorac, and Retin-A. Tretinoin not ...
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REVIEW : Bald! a reflection on the world’s superior headsDec 25, 2005 Arkansas Democrat-Gazette (subscription), Yet this is a reality that millions upon millions of people simply refuse to acknowledge, now as always, which explains Botox and Retin-A and Viagra and any ...
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