Alendronate resources


DRUG INFO
Alendronate

Drug Name: Alendronate

Indication: For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women



Pharmacology: Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.

Mechanism Of Action: The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Alendronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Drug Category: Antiresorptives; Bisphosphonates; Antihypocalcemic Agents; ATC:M05BA04

Brand Names/Synonyms: ALENDRONIC ACID; Acide Alendronique [Inn-French]; Acido Alendronico [Inn-Spanish]; Acidum Alendronicum [Inn-Latin]; Adronat; Alendronate; Alendronate Sodium; Alendronic Acid; Alendronic Acid [Ban:Inn]; Alendros; Arendal; CHEMBANK1709; Fosamax; MK 217; Onclast

Dosage Forms: 10 mg (Rx) Fosamax lactose 40 mg (Rx) Fosamax lactose

Absorption: Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.

Interactions: Intravenous ranitidine was shown to double the bioavailability of oral alendronate. The clinical significance of this increased bioavailability and whether similar increases will occur in patients given oral H2-antagonists is unknown; no other specific drug interaction studies were performed. Products containing calcium and other multivalent cations likely will interfere with absorption of alendronate.



Chemical IUPAC Name: (4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid

Chemical Formula: C4H13NO7P2

Half Life: >10 years

Drug Type: Approved Drug

# Accession No: APRD00561

CAS Registry Number: 66376-36-1



Alendronate News
(When available)



What Causes Osteoporosis?  Feb 6, 2006
Calcium and vitamin D supplements as mentioned previously are often paired with bisphosphonates like Alendronate and Risedronate, selective estrogen receptor ... - DailyIndia.com,

It is Predicted in the Next Ten Years the Demand for Drugs to ...  Feb 3, 2006
Procter & Gamble. With the bisphosphonate alendronate (Fosamax), Merck holds a 39% market share in the seven major markets. Lilly's 17 ... - International News Service,

European positive opinion for first quarterly IV injection for  Jan 27, 2006
Patient preference for once-monthly ibandronate versus one-weekly alendronate in a randomized, open-label, cross-over trial: the Boniva Alendronate Trial in ... - WebWire (press release),

Denosumab shows increased bone mineral density in postmenopausal ...  Jan 21, 2006
60mg increased BMD of the lumbar spine by 7.4 percent in women administered the therapy twice yearly and 6.2 percent for Fosamax ( Alendronate ) 70mg weekly. ... - Xagena.it,

UPDATE: Hungary's Richter: Wins Drug Patent Case Vs Merck  Jan 18, 2006
...said. Original drug manufacturer Merck launched the infringement case against Richter over Sedron's active ingredient alendronate. ... - Business Online,

Merck Announces Strong Full-Year and Fourth-Quarter 2005 Earnings ...  Jan 31, 2006
Sales outside of the United States were affected by theavailability of generic alendronate sodium products in some markets,including the United Kingdom, Canada ... - Finanzen.net,

ANALYST VIEW - Erste ups Richter net profit estimate, price target  Jan 25, 2006
...any of Merck's patents by manufacturing and distributing Sedron, a generic equivalent to Merck's Fosamax (an anti-osteoporosis drug containing alendronate). ... - Portfolio.hu,

Merck profits edge ahead in fourth quarter  Feb 1, 2006
Hyzaar (losartan and hydrochlorothiazide), advanced 2% to $782 million in the fourth quarter, although the osteoporosis drug Fosamax (alendronate) declined 5 ... - Pharma Times (subscription),

Treatments for excess parathyroid hormone  Jan 17, 2006
Medication to control the effects of hyperparathyroidism on the bones is possible, too - osteoporosis drugs such as Fosamax (alendronate) and Actonel ... - Newsday,

Boniva for injection cleared in USA  Jan 9, 2006
...version has seen modest sales growth, as it was competing with once-weekly products including market leader Merck & Co's Fosamax (alendronate), which makes ... - Pharma Times (subscription),

PHARMAC invests $103 million in NZers’ health  Jan 8, 2006
...“For example, an increase in the number of people taking alendronate for osteoporosis could reduce the number of hip replacements in the future. ... - Scoop.co.nz (press release),

Merck loses lawsuit against Richter  Jan 18, 2006
...the first instance, Richter was obliged to suspend the production and distribution of its anti-osteoporosis product, Sedron, containing alendronate, which is a ... - Portfolio.hu,

Health checkup: Food and drug interactions  Jan 18, 2006
...side effects. The absorption of alendronate (Fosamax), a drug to prevent osteoporosis, is decreased by almost everything. It should ... - Rochester Democrat and Chronicle,

Doctors May Neglect Bone Loss When Prescribing Steroids  Jan 16, 2006
...osteoporosis. They are Fosamax (alendronate) manufactured by Merck, and Actonel (risedronate), made by Procter & Gamble, the authors noted. ... - MedPage Today,

Loyola to study for first time IV medication for osteopenia and ...  Jan 10, 2006
Oral osteoporosis medications such as alendronate and risedronate may exacerbate the problem because main side effects are gastric ulcers, abdominal pain and ... - News-Medical.net, Vanuatu Villagers May Be First Climate Change 'Refugees'  Dec 20, 2005
Port Vila Presse, Details of the scheme were unveiled at a meeting organized by the United Nations Environment Programme's (UNEP) polar centre, GRID Arendal in Norway. ...

GE en ANZ investeringsbank regelen faciliteit 120 miljoen dollar ...  Dec 13, 2005
Netherlands Corporate News (persbericht), Sevan Marine has offices in Tananger and Arendal, Norway and Rio de Janeiro, Brazil. The Company is listed on the Oslo Stock Exchange with ticker code SEVAN. ...

Exercise weighs in to slow bone loss from osteoporosis  15 Jan 2006
Fort Wayne Journal Gazette, ...when she was diagnosed with osteopenia – a precursor to osteoporosis – 10 years ago, she started taking calcium supplements and a drug, Fosamax, to try to ...

FDA OKs First IV Osteoporosis Drug  Jan 13, 2006
WebMD However, men can also develop osteoporosis. Boniva belongs to a family of drugs called biphosphonates, which also include Actonel and Fosamax. ...

DemiDose(TM) Pill Splitter Allays Concern Over Dose Accuracy in ...  Jan 11, 2006
PR Newswire (press release), By design, DemiDose(TM) specifically splits many of the highest priced brand name prescription pharmaceutical tablets, eg, Cialis(R), Fosamax(R), Levitra(R ...

Boniva for injection cleared in USA  Jan 9, 2006
Pharma Times (subscription), This version has seen modest sales growth, as it was competing with once-weekly products including market leader Merck & Co's Fosamax (alendronate), which ...

Osteoporosis drug backed  Jan 8, 2006
Trade Arabia, It is the latest entrant in the multibillion-dollar osteoporosis market that includes Sanofi-Aventis' Fosamax and Procter & Gamble's Actonel.

DemiDose(TM) Pill Splitter Allays Concern Over Dose Accuracy in ...  Jan 11, 2006
Yahoo! News (press release) ...design, DemiDose(TM) specifically splits many of the highest priced brand name prescription pharmaceutical tablets, eg, Cialis®, Fosamax®, Levitra®, Lipitor ...

Tonic for high drug costs  Jan 1, 2006
Indianapolis Star, For instance, in New York, a three-month supply of Lipitor (20 mg) or Fosamax (70 mg) costs $413 under the least expensive Medicare plan, but $516 from Canada. ...

Medicare confusion compounded by technical glitches  Dec 15, 2005
Greenwich Time, The site calculates for a 30-day supply of the brand-name drug, called Fosamax, even when seniors are seeking estimates for plans in which they only take the ...

Actonel makers sue GSK and Roche over Boniva ads  Jan 5, 2006
Pharma Times (subscription), ...trying to make gains in a competitive marketplace currently dominated by Merck & Co's $3.2 billion-dollar-a-year market leader, Fosamax (alendronate), approved ...

New Medicare drug plan for seniors has many scratching their heads  Jan 8, 2006
North County Times, The AARP site gives additional information outlining savings available from generic alternatives. In this example, Fosamax and Lipitor could be split. ...

Advair may get a stronger warning label  Jan 11, 2006
Daily Press, ...blood pressure and Actos for diabetes. My wife takes Fosamax for her bones and Aciphex for reflux. It became essential for us to ...

No anesthesia: Merck cuts deeper to save money  Dec 16, 2005
Chicago Sun-Times, ...expiration. Some other drugs, including popular osteoporosis pill Fosamax, lose patent protection over the next few years. Clark ...

Study: Drugs from Canada may not be best buy  Dec 30, 2005
Kansas City Star, For instance, in New York, a three-month supply of Lipitor (20 mg) or Fosamax (70 mg) costs $413 each under the least expensive Medicare plan, but $516 from ...

Merck to Ax $1B More in Costs Through 2010  Dec 15, 2005
Herald News Daily, ...expiration. Some other drugs, including popular osteoporosis pill Fosamax, lose patent protection over the next few years. Despite ...

Merck hikes cost-cutting target to $5B  Dec 15, 2005
Newark Star Ledger, ...generic rivals starting next year. A similar fate awaits the Fosamax osteoporosis treatment in 2008. Moreover, Merck now faces 9,200 ...

Sapphire Therapeutics, Inc. Builds Drug Development Team Through ...  Jan 9, 2006
dBusinessNews Newark (press release), ...clinical development positions at Theravance, Wyeth and Merck, where he played a key role managing clinical trials that led to the approval of Fosamax(R) and ...

Did a British university sell out to Procter & Gamble?  Dec 22, 2005
Slate In 2004, P&G's main rival, Merck, was due to publish a head-to-head study comparing its osteoporosis drug, Fosamax, with Actonel. ...

Drug Prices in Medicare Plans are 48% Higher Than Veterans' Prices  Dec 22, 2005
Common Dreams (press release), Fosamax (70 mg., osteoporosis treatment): lowest VA price is $493.32; lowest Medicare plan price is $709.68 - a difference of $216.36, or 43.9 percent. ...

UPDATE 1-Roche, Glaxo: US OKs new use for osteoporosis drug  Jan 6, 2006
Reuters It is the latest entrant in the multibillion-dollar osteoporosis market that includes Sanofi-Aventis' (SASY.PA: Quote, Profile, Research) Fosamax and Procter & ...

Merck Unveils Plan to Reclaim Leadership Position  Dec 15, 2005
Business Wire (press release), WORLDWIDE PRODUCT 2005 SALES ----- ZOCOR (Cholesterol modifying) $4.2 to $4.5 billion FOSAMAX (Osteoporosis) $3.1 to $3.4 billion COZAAR/HYZAAR ...

... Go to the Article  Jan 4, 2006
CancerWise ...loss. Bisphosphonates, a family of drugs used to prevent and treat osteoporosis, include Fosamax®, Actonel® and Boniva®. The ...

The People's Pharmacy  Jan 1, 2006
Seattle Times, Q: My job was outsourced last year, and I lost my health coverage. I take Lipitor, Norvasc, Altace, Toprol-XL and Actos. My wife takes Fosamax and Aciphex. ...

Medicare drug plans much costlier than VA drugs  Jan 4, 2006
Rock River Times, ...higher. Fosamax, 70 mg., osteoporosis treatment, VA: $493.32; Medicare: $709.68, a difference of $216.36 or 43.9 percent higher. ...

Preventing bone loss is best protection  Dec 13, 2005
Newsday, Boniva reminds me of two similar drugs on the market, Actonel and Fosamax. They work by slowing down the activity of cells in your body that cause bone loss. ...

Merck Chief Clark, After Cost Cuts, Needs Purchases (Update1)  Dec 14, 2005
Bloomberg Merck will also face generic competition in 2008 to its Fosamax osteoporosis treatment, the company's second-biggest- selling product, with $3.2 billion in ...

Lilly to pay $36M fine for false claims  Dec 22, 2005
Indianapolis Star, ...after first-year sales of Evista came in far below its expectations and the drug faced competition from two established rival products, Fosamax and hormone ...

Study: Private plans more expensive to Medicare  Dec 22, 2005
Bradenton Herald, Medicare. Other examples include Fosamax for osteoporosis: $493.32 versus $709.68. And Protonix for acid reflux: $253.32 versus $1,080. ...

I'm shrinking  Dec 25, 2005
Belleville News-Democrat, ...bearing exercise (walking, weightlifting, etc.), to consume plenty of calcium, and, when appropriate, to take a drug such as Boniva or Fosamax, which inhibits ...

Merck reveals plans for rebirth  Dec 16, 2005
NorthJersey.com, ...expiration. Several other drugs, including the popular osteoporosis pill Fosamax, lose patent protection over the next few years. ...

Merck details plan to return to profitability  Dec 19, 2005
In-PharmaTechnologist.com, ...expiration. Indeed, some other drugs, including popular osteoporosis pill Fosamax, lose patent protection during the next few years. ...

Newly Released Discount Coupons and Callback Buttons Help ...  Dec 14, 2005
Emediawire (press release), This special offer provides you with savings up to 60% on Fosamax, Zocor, Norvasc, Pravachol and 6000 other brand and generic medications! ...


Home Copyright phasechange.org 2006.
All Rights Reserved.
Google
 
Web rxreview.org