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Alefacept
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DRUG INFO
Alefacept
Drug Name:
Alefacept
Indication: For treatment of moderate to severe chronic plaque psoriasis
Pharmacology: Interferes with lymphocyte activation by specifically binding to the lymphocyte antigen, CD2, and inhibiting LFA-3/CD2 interaction. Activation of T lymphocytes involving the interaction between LFA-3 on antigen-presenting cells and CD2 on T lymphocytes plays a role in the pathophysiology of chronic plaque psoriasis. Also causes a reduction in subsets of CD2+ T lymphocytes as well as CD4+ and CD8+ T lymphocytes.
Mechanism Of Action: Inhibits T-lymphocyte activation and production by binding to the CD2 lymphocyte antigen.
Drug Category: Immunomodulatory Agents; Immunosuppresants; misc. skin and mucous membrane agents (84:92.00)
Brand Names/Synonyms: Amevive; Amevive (Biogen Inc.)
Dosage Forms: POWDER FOR SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Human LFA-3/IgG1 fusion protein
Chemical Formula: C2306H3594N610O694S26
Half Life: ~270 hours
Drug Type: Approved Drug
# Accession No: BIOD00055
CAS Registry Number: 222535-22-0
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Alefacept News
(When available)
Clinical Trials Update: Dec. 9, 2005 Dec 9, 2005
Atlanta Journal Constitution (subscription), Biogen Idec, the maker of AMEVIVE (Alefacept), has established a registry to collect information on pregnancies and the children of those pregnancies exposed ...
New Drugs Offer More Choices for Psoriasis Dec 21, 2005
Spartanburg Herald Journal (subscription), Since 2003, biologic drugs approved for psoriatic arthritis or psoriasis include Remicade; alefacept, sold as Amevive; etanercept, sold as Enbrel; efalizumab ...
Two-Pronged Approach Targets Psoriasis Dec 27, 2005
WMTW, ...the hospital. Dr. Steven Feldman used a new approach that included a weekly shot of a drug called Amevive. "In psoriasis, patients ...
New Drugs Offer More Choices for Psoriasis Dec 21, 2005
Spartanburg Herald Journal (subscription), Since 2003, biologic drugs approved for psoriatic arthritis or psoriasis include Remicade; alefacept, sold as Amevive; etanercept, sold as Enbrel; efalizumab ...
Biologic drugs the latest psoriasis weapon Dec 20, 2005
United Press International It as well as Amevive, Enbrel, Humira and Raptiva have been approved to treat psoriasis and psoriatic arthritis since 2003, the newspaper reported. ...
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