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Aldesleukin
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DRUG INFO
Aldesleukin
Drug Name:
Aldesleukin
Indication: For treatment of adults with metastatic renal cell carcinoma
Pharmacology: Used to treat renal cell carcinoma, proleukin induces the enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human interleukin-2 dependent cell lines, the enhancement of lymphocyte cytotoxicity, the induction of killer cell (lymphokine-activated (LAK) and natural (NK)) activity; and the induction of interferon-gamma production. IL-2 is normally produced by the body, secreted by T cells, and stimulates growth and differentiation of T cell response. It can be used in immunotherapy to treat cancer. It enhances the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor.
Mechanism Of Action: Proleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.
Drug Category: Antineoplastic Agents
Brand Names/Synonyms: Interleukin-2 precursor;IL-2;T-cell growth factor;TCGF; Proleukin (Chiron Corp)
Dosage Forms: POWDER FOR SOLUTION
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Human interleukin 2 (modified)
Chemical Formula: C690H1115N177O202S6
Half Life: 13 min-85 min
Drug Type: Approved Drug
# Accession No: BIOD00082
CAS Registry Number: 85898-30-2
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Aldesleukin News
(When available)
Study shows relaxation helps healing after surgery 16 Jan 2006
Knoxville News Sentinel (subscription), One, Interleukin-6 (IL-6), works to maintain balance in the immune response. The higher the level generally, the more the healing process is stimulated. ...
Combination of Interleukin-12 Interferon and appears to be safe Jan 7, 2006
Xagena.it, A research has shown that the immune-stimulating hormone known as Interleukin-12 ( IL-12 ) can safely be administered with Interferon, another immune-system ...
American Stock Exchange Lists Common Stock of Interleukin Genetics Dec 28, 2005
Business Wire (press release), WALTHAM, Mass.--(BUSINESS WIRE)--Dec. 28, 2005--Interleukin Genetics, Inc. ... Philip R. Reilly, Chief Executive Officer of Interleukin Genetics, Inc. ...
American Stock Exchange Lists Common Stock of Interleukin Genetics ... Dec 28, 2005
PR Newswire (press release), NEW YORK, Dec. 28 /PRNewswire/ -- The American Stock Exchange(R) (Amex(R)) today listed the common stock of Interleukin Genetics, Inc. ...
Interleukin moves to American Stock Exchange Dec 28, 2005
Boston Business Journal, ...under the ticker symbol ILI. Interleukin had been traded over the counter under the ticker symbol ILGN. CEO Philip Reilly said in ...
Interleukin Genetics listed on American Stock Exchange Dec 28, 2005
Boston Mass High Tech, As of today, the common shares of Interleukin Genetic Inc. are listed on the American Stock Exchange under the ticker symbol ILI. ...
Researchers Show That Patterns of Genetic Variation Leading to ... Jan 11, 2006
Business Wire (press release), 11, 2006--Interleukin Genetics (AMEX: ILI) reports today that interactions of variations commonly found in the promoter region of a gene that plays a key role ...
Shocking Away Melanoma Jan 10, 2006
WFtv.com, ...before the tumor membrane pores close again. These plasmids contain the gene for interleukin-12. Adil Daud, MD, an oncologist at ...
Bio-Tech Company Conquers Lupus, and a Few Others Jan 13, 2006
Christian News Wire (press release), ...this proliferative gene channel, Kv1.3+, the proto-oncogene p56lck is kept "asleep" and the chemical it produces causing cell death, IL-2 (InterLeukin 2) is ...
Endothelin–an emerging role in proinflammatory pathways in brain Dec 29, 2005
AJP-Regul Integr Comp Physiology (subscription) ...ucalgary.ca). Ahmed MS, Llanos Q, Dinarello CA, and Blatteis CM. Interleukin 1 reduces opioid binding in guinea pig brain. Peptides 6 ...
Recent Advances in Biologic Therapies Jan 6, 2006
Medscape (subscription) Tocilizumab is a humanized monoclonal antibody to the interleukin (IL)-6 receptor and has been found to be effective in a phase 2, dose-ranging study in RA ...
Older women can fight off inflammation with lots of sleep and a ... Jan 3, 2006
Newstarget.com, University of Wisconsin in Madison, oversaw the research that determined two factors were instrumental in keeping a harmful protein known as interleukin-6 at a ...
Herceptin may work better when it is followed by injections of ... Jan 5, 2006
News-Medical.net, ...new study is the first to indicate that the drug trastuzumab, also known as Herceptin, may work better when it is followed by injections of interleukin (IL) 2 ...
Immune stimulants may help cancer patients, study shows Jan 9, 2006
Pharmaceutical Business Review ...is the first to indicate that the drug trastuzumab (marketed by Genentech as Herceptin) may work better when it is followed by injections of interleukin (IL) 2 ...
Immune-system boosters aid cancer drugs Jan 9, 2006
United Press International ...that found that the cancer drug Herceptin (trastuzumab) may be even more effective in fighting breast cancer when followed by injections of interleukin (IL) 2 ...
Gene increases risk of tuberculosis Jan 8, 2006
Xagena.it, But extremely high levels of MCP-1 can be dangerous, as they inhibit the production of another immune protein called interleukin-12. ...
CSU equine orthopedic research brings equine athletes back into ... Jan 5, 2006
CSU e-comment, IRAP, which stands for Interleukin-1 Receptor Antagonist Protein Procession System, is a substance that blocks the excessive production of synovial fluid in ...
Sound sleep, social bonds help against diseases Dec 18, 2005
Webindia123, As part of the normal aging process, the amount of the protein Interleukin-6 (IL-6) in the bloodstream automatically increases. ...
New Treatment For Kidney And Skin Cancer Dec 27, 2005
KLTV, ...kidney cancer. A new treatment called Interleukin-2 looks promising for people who have kidney cancer or melanoma. Susan Griffis ...
How Do Islet Cells Die During Early Stages Of Diabetes? Dec 19, 2005
Medical News Today (press release), Citation: Steer SA, Scarim AL, Chambers KT, Corbett JA (2005) Interleukin-1 stimulates b-cell necrosis and release of the immunological adjuvant HMGB1. ...
Prophylaxis Against Postoperative Atrial Fibrillation Current ... Dec 29, 2005
Journal of American Medical Association (subscription), The 174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation: is atrial fibrillation an ...
Tanox Submits IND Application For TNX-650 For Treatment Of ... Dec 21, 2005
Pharmaceutical Processing, ...transplantation. TNX-650 is a monoclonal antibody targeting Interleukin 13, an important growth factor for malignant lymphoma cells. ...
FDA approves promising drug for kidney cancer Dec 21, 2005
Chicago Tribune, The current standard treatment for kidney cancer--immune therapy with interferon or interleukin-2--has only modest benefits and can be extremely toxic. ...
New drug combo may boost cancer treatment Jan 5, 2006
Science Daily (press release) ...is the first to indicate that the drug trastuzumab -- also known as Herceptin -- may work better when it is followed by injections of interleukin, IL-2 or IL-12 ...
Carbon Monoxide Soothes Inflammatory Bowel Disease Jan 3, 2006
Science Daily (press release) ...in mice. The group traced the action of inhaled CO to a protein that is produced by immune cells called interleukin (IL)-12. IL-12 ...
FDA Approves Nexavar for Kidney Cancer Dec 22, 2005
ACS News Center, The patients in the study all had renal cell carcinoma that had spread, and most had already been treated with interleukin-2 or interferon. ...
Genaera Corporation to Host Investor Conference Call to Review ... Jan 3, 2006
PR Newswire (press release), Genaera's other programs include: squalamine for the treatment of cancer; interleukin-9 antibody, a respiratory treatment based on the discovery of a genetic ...
An Overview of the Clinical Molecular Diagnostic Tests Currently ... Jan 5, 2006
Genetic Engineering News, Incyte Pharmaceuticals - Infectio Diagnostic Inc - Innogenetics NV/SA - InnoGenex - Interleukin Genetics - Invitrogen - Kreatech Diagnostics - LabCorp - LI ...
The role of genes in the development of non-Hodgkin's lymphomas Dec 15, 2005
News-Medical.net, ...out that variations of individual DNA building blocks in genes encoding for the cellular signaling molecules tumor necrosis factor (TNF) and interleukin 10 (IL ...
Clinic proposes new cancer center Jan 5, 2006
OregonLive.com, The current clinics offer chemotherapy, radiation therapy and biotherapy, which includes such treatments as interferon and interleukin. ...
Kidney cancer drug gets FDA approval Dec 20, 2005
USA Today Pazdur noted that Nexavar, a pill, is easier on patients than standard treatments, such as interferon and interleukin-2, which are typically given in an ...
FDA: New drug for kidney cancer "a major advance" Dec 20, 2005
Xinhua, Unlike the current standard treatment for kidney cancer - immune therapy with interferon or interleukin-2 - which has only modest benefits but can be extremely ...
Two classicists, two molecular geneticists chosen for science ... Dec 26, 2005
Jerusalem Post, He has done fertile and original research on protein synthesis and isolation of interferon-beta and interleukin-6 proteins and the cloning of genes that encode ...
FDA Approves New Treatment for Advanced Kidney Cancer Dec 20, 2005
FDA.gov ...progression or death. In the larger study, most patients had previously received treatment with interleukin-2 or interferon. The median ...
FDA Approves Nexavar(R) for Treatment of Patients with Advanced ... Dec 20, 2005
Yahoo! News (press release) All subgroups examined, including patients who had not received conventional treatment with biologics, such as interleukin-2 or interferon-alpha, appeared to ...
FDA Approves Drug for Advanced Kidney Cancer Dec 20, 2005
MedPage Today, ...antiangiogenesis agent. The FDA said the larger study recruited patients who had previously been treated with interleukin-2 or inteferon. In ...
Nexavar cleared in USA for kidney cancer Dec 21, 2005
Pharma Times (subscription), Meanwhile, Nexavar appears to be much less toxic than current treatments for this type of cancer, such as interleukin-2 or interferon-alpha, and has the ...
FDA approves drug for patients with advanced kidney cancer Dec 21, 2005
Baltimore Sun, The current standard treatment for kidney cancer - immune therapy with interferon or interleukin-2 - has modest benefits and can be extremely toxic. ...
NeoPharm, Inc. Announces PRECISE Trial Update Dec 27, 2005
Genetic Engineering News, Cintredekin besudotox is a recombinant protein consisting of a single molecule composed of two parts: a tumor-targeting molecule (Interleukin-13, or IL13) and ...
FDA approves Kidney cancer drug Dec 21, 2005
Andhra Cafe, ...few side effects, and some patients who started taking it more than two years ago are still doing well, as compared with interferon or interleukin with more ...
(PRN) - Goodyear Completes Sale of North American Farm Tire Assets ... Dec 28, 2005
Bolsamania.com, Shareholding (2) ... [. PRN) - American Stock Exchange Lists Common Stock of Interleukin Genetics Incorporated ... [+. PRN) - royal ...
FDA approves Bayer's Nexavar for advanced kidney cancer Dec 21, 2005
Food Consumer, In patients who previously received treatment with interleukin-2 or interferon, those who took Nexavar had 167 days before the tumor progressed compared to 84 ...
Advanced renal cell carcinoma: FDA approves Nexavar Dec 21, 2005
Xagena.it, All subgroups examined, including patients who had not received conventional treatment with biologics, such as Interleukin-2 or Interferon-alpha, appeared to ...
FDA Approvals: Nexavar and Tamiflu Dec 28, 2005
Medscape (subscription) ...among all patient subgroups evaluated in the study, including patients who had not received conventional treatment with biologics such as interleukin-2 or ...
Stockholders of Maxim Pharmaceuticals Approve Merger Proposal Dec 21, 2005
Finanzen.net, Maxim has completed one Phase 3clinical trial of Ceplene(TM) plus Interleukin-2 combination therapyas a remission maintenance therapy for patients with acute ...
Stockholders of Maxim Pharmaceuticals Approve Merger Proposal Dec 21, 2005
Business Wire (press release), Maxim has completed one Phase 3 clinical trial of Ceplene(TM) plus Interleukin-2 combination therapy as a remission maintenance therapy for patients with acute ...
Global Inflammation: a Cardiovascular Risk Marker in Women Dec 28, 2005
Medscape (subscription) NEW YORK (Reuters Health) Dec 28 - Elevated levels of inflammatory markers including C-reactive protein and interleukin 6 (IL-6) predict cardiovascular risk in ...
Synta Pharmaceuticals to Focus 2006 Development on Its Oral IL-12 ... Dec 23, 2005
Yahoo! News (press release) STA-5326 is the first and only oral, small-molecule, selective inhibitor of the interleukin (IL)-12 cytokine family, which includes IL-12 and IL-23. ...
Smoke Toxin may Battle Bowel Disease Dec 20, 2005
Ivanhoe, Results revealed carbon monoxide inhibits the production of interleukin-12, a protein produced by immune cells when the body is faced with invading germs. ...
Investigative Antiviral Agent Aplaviroc Lowers Viral Load without ... Dec 22, 2005
DG News The chemokines assessed included regulated on activation normal T cell expressed and secreted (RANTES), MIP-1 alpha MIP-1 beta, interleukin-8 (IL-8), membrane ...
UTHCT Scientist Identifies Genetic Mutation Linked to TB Dec 19, 2005
Newswise (press release) The high level of MCP-1 restricts the production of another crucial chemical, interleukin-12, a key factor in controlling infection, he said. ...
Carbon monoxide soothes bowel disease Dec 19, 2005
United Press International Plevy and his colleagues at the University of Pittsburgh tested the theory on mice and found that inhaled CO inhibited the production of interleukin (IL)-12 by ...
Studies Show Benefits of Newborn Screening for ‘Bubble Boy ... Dec 19, 2005
Newswise (press release) In the retrospective analysis, investigators measured serum or plasma levels of interleukin-7 (IL-7), a T-cell growth cytokine elevated in SCID, in combination ...
Synta Pharmaceuticals to Focus 2006 Development on Its Oral IL-12 ... Dec 23, 2005
PR Newswire (press release), ...plan decisions reached for each Synta program: STA-5326 STA-5326 is the first and only oral, small-molecule, selective inhibitor of the interleukin (IL)-12 ...
Infectious Agent Thwarts Typical Defense Mechanisms Dec 21, 2005
Newswise (press release) Wewers said. That response was characterized by an overwhelming increase of a chemical messenger called interleukin-1 beta (IL-1B). IL ...
Shocking away melanoma Dec 30, 2005
News 8 Austin, ...far. Daud said biopsies and blood samples reveal they are getting the expression of the interleukin-12 gene protein into the tumor. ...
‘Transfusion not necessary’ Dec 18, 2005
Trinidad News, ...increase white blood cells. Interleukin-11 and, when available, thrombopoietin may be used to increase platelets. Other medications can ...
Smoke gets in your skin Dec 20, 2005
Globe and Mail, Some of these small proteins, or cytokines such as interleukin and tumour necrosis factor, have been associated with severity of psoriasis symptoms. ...
Zenotech to launch two bio generics in Feb, plans GDR Dec 20, 2005
Newindpress, The company is planning to launch another bio generic for oncology, Interleukin-2 (IL-2) in the third quarter of the next financial year. ...
Announcement and Resource Dec 18, 2005
Journal of Clinical Endocrinology and Metabolism, The article by Illig et al., "Significant Association of the Interleukin-6 Gene Polymorphisms C-174G and A-598G With Type 2 Diabetes" (J Clin Endocrinol Metab ...
Nexavar® Approved by the FDA for Renal Cell Carcinoma Dec 28, 2005
Cancer Consultants (press release), ...options for metastatic renal cell carcinoma consist of palliative surgery, radiation therapy, or immune-stimulating agents such as interleukin or interferon. ...
Polymorphism And Antibodies Associated With Highly Increased Risk ... Dec 27, 2005
Science Daily (press release) Promising For Rheumatoid Arthritis (February 14, 2002) -- Northwestern University researchers have reported the first successful use of interleukin-13 (IL-13 ...
Combo of immune substances proves safe Dec 13, 2005
myDNA.com, New research shows that the immune-stimulating hormone known as interleukin-12 (IL-12) can safely be administered with interferon, another immune-system protein ...
Active Biotech Reports Interim Results of ANYARA Phase I Clinical ... Dec 14, 2005
Market Wire (press release) ...generated. These include a sustained level of the immunostimulatory cytokine Interleukin 2 (IL-2) after the second day of treatment. ...
Partnership to develop new renal cancer test Dec 13, 2005
OutSourcing-Pharma.com, ...diverse symptoms, resistance to radiation and chemotherapy, and infrequent responses to immunotherapy agents such as interferon alpha and interleukin (IL)-2. ...
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