Albuterol resources


DRUG INFO
Albuterol

Drug Name: Albuterol

Indication: For relief and prevention of bronchospasm due to asthma; Emphysema; Chronic bronchitis



Pharmacology: Albuterol, a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity.

Mechanism Of Action: Albuterol is a beta(2)-adrenergic agonist. It stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that Albuterol increases cAMP production by activating adenylate cyclase, and the actions of albuterol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentrations leads to a smooth muscle relaxation. Increased intracellular cyclic AMP concentrations also cause an inhibition of the release of mediators from mast cells in the airways.

Drug Category: Adrenergic beta-Agonists; Tocolytic Agents; Bronchodilator Agents; ATC:R03AC

Brand Names/Synonyms: AH 3365; Accuneb; Aerolin; Albuterol; Albuterol Sulfate; Albuterol Sulfate Hfa; Asmaven; Broncovaleas; Cetsim; Cobutolin; Ecovent; Loftan; Proventil; Proventil Inhaler; Proventil-Hfa; Rotahaler; Salbulin; Salbutamol; Salbutamol Free Base; Salbutamol Sulfate; Salbutamol Sulphate; Salbutard; Salbutine; Salbuvent; Solbutamol; Sultanol; Venetlin; Ventalin Inhaler; Ventolin; Ventolin Hfa; Ventolin Inhaler; Ventolin Rotacaps; Volma; Volmax; Xopenex; Xopenex Hfa

Dosage Forms: ORAL SOLUTION; SYRUP; TABLETS; EXTENDED-RELEASE TABLETS; INJECTION (Intramuscular, Intravenous)

Absorption: Systemic absorption is rapid following aerosol administration

Interactions: DrugBank: Interactions for Albuterol

Interactions for Albuterol:


Other short-acting sympathomimetic aerosol bronchodilators should not be used concomitantly with albuterol. If additional adrenergic drugs are to be administered by any route, they should be used with caution to avoid deleterious cardiovascular effects.

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants: Albuterol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of albuterol on the vascular system may be potentiated.

Beta-Blockers: Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as VENTOLIN Inhalation Aerosol, but may produce severe bronchospasm in patients with asthma. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.

Diuretics: The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

Digoxin: Mean decreases of 16% to 22% in serum digoxin levels were demonstrated after single-dose intravenous and oral administration of albuterol, respectively, to normal volunteers who had received digoxin for 10 days. The clinical significance of these findings for patients with obstructive airway disease who are receiving albuterol and digoxin on a chronic basis is unclear. Nevertheless, it would be prudent to carefully evaluate the serum digoxin levels in patients who are currently receiving digoxin and albuterol.

 

 





Chemical IUPAC Name: 2-(hydroxymethyl)-4-(1-hydroxy-2-tert-butylamino-ethyl)-phenol

Chemical Formula: C13H21NO3

Half Life: 1.6 hours

Drug Type: Approved Drug

# Accession No: APRD00553

CAS Registry Number: 18559-94-9



Albuterol News
(When available)



Hospital takes on asthma in young  09 Feb 2006
And those who do know "often I see them sucking on an albuterol inhaler but they may not have controller medications.". Albuterol ... - Pittsburgh Post Gazette,

FDA considers ban on some inhalers  Jan 25, 2006
...layer. In March, the FDA said inhalers using CFCs to dispense the prescription drug Albuterol would be banned at the end of 2008. ... - Asbury Park Press,

Proposed Inhaler Ban  Jan 31, 2006
Last March, the FDA said inhalers that use CFC's to dispense the prescription drug Albuterol would be banned at the end of 2008. ... - Central Florida News 13,

Sepracor Announces Fourth Quarter and Full Year 2005 Results ...  Jan 31, 2006
In March 2005, the FDA issued its final rule for removal of the essential use exemption for albuterol, which currently permits use of CFC-containing albuterol ... - Genetic Engineering News,

Hospital pharmacist a drug cost watchdog  Jan 28, 2006
When Klein considered Xopenex, she asked: Was Xopenex, a derivative of albuterol, better than a generic? If so, were the benefits worth the added cost? ... - Palm Beach Post,

Sepracor Announces Fourth Quarter and Full Year 2005 Results ...  Jan 31, 2006
In March 2005, the FDA issued its final rule for removalof the essential use exemption for albuterol, which currently permitsuse of CFC-containing albuterol ... - Finanzen.net,

Some asthmatics may lose their inhalers  Jan 16, 2006
Allergists say that epinephrine provides less of a benefit than generic albuterol, which is available as a prescription. "Inhaled ... - CNN/Money

Hospital Cost Cutting Could Trigger Lawsuits  Jan 22, 2006
...company, Blue Shield of California, felt the same way about Xopenex as Ms. Klein; the insurer removed the drug from its formulary and substituted albuterol. ... - Los Angeles Times,

Westchester Medical Center and other facilities coordinate care  Jan 9, 2006
He said he had been giving her albuterol to help her breathe. "If she's got croup, don't give her albuterol," Goltzman advised. ... - The Journal News.com,

Breathe Easier!  Jan 22, 2006
Clenbuterol, terbutaline, and albuterol belong to a class of bronchodilators called beta-adrenergic agonists (or beta-2 receptor agonists). ... - TheHorse.com,

Primatene Mist May Be Pulled From Market  Jan 24, 2006
Instead of Primatene Mist, physicians most often use a drug called albuterol to provide quick-acting relief to patients who suffer the symptoms of asthma. ... - ABC News

OTC asthma inhalers on the verge of extinction  Jan 24, 2006
Prescription inhalers use albuterol as their active compound and HFA as a propellant. Albuterol is more effective in treating asthma ... - CNN International

Panel Advises Barring Sale of Inhalers  Jan 24, 2006
Many doctors question whether over-the-counter inhalers like Primatene Mist should even be sold. Most recommend the use of prescription albuterol inhalers. ... - New York Times,

Advances move stem cells closer to clinic  Jan 26, 2006
...it could very quickly move into the clinic,' Scadden told UPI. Potential candidates include terbutaline and albuterol, he said. - Monsters and Critics.com,

Equine Respiratory Disease Part 2: The Lower Airway  Jan 15, 2006
The drug albuterol (common human asthma drug) has been used in the horse, but our clinical pharmacology laboratory has just recently determined that albuterol ... - TheHorse.com,

Panel wants FDA to stop sale of some inhalers  Jan 25, 2006
In March, the FDA said that inhalers using CFCs to dispense the prescription drug albuterol would be banned at the end of 2008. ... - Winston-Salem Journal,

INHALERS BANNED OVER OZONE EFFECT?  Jan 25, 2006
...version. The FDA has already banned CFC-driven inhalers for the prescription-only asthma drug albuterol, starting at the end of 2008. ... - Free Market News Network,

FDA Panels Calls for Banning OTC Asthma Inhalers  Jan 25, 2006
...appropriate treatment for their asthma symptoms. Many physicians prescribe albuterol inhalers. Pramod Kelkar, MD, of Minneapolis ... - MedPage Today,

Panel recommends Primatene mist ban  Jan 25, 2006
But there are other, better, medicines available if that occurs--like albuterol--which is longer acting and has fewer side effects. ... - WTNH,

Industry Insider: Waning shipments force drug importer to shut ...  Jan 18, 2006
Meanwhile, some doctors say rival inhalers, specifically generic albuterol, may be more beneficial to patients than Primatene Mist, which contains an ... - Newark Star Ledger,

ACMH, ArmsCare donate nebulizers to schools for students with ...  Jan 30, 2006
...compressor. Patients use a face mask or mouthpiece to inhale a fine mist medication, such as albuterol, deep into their lungs. In ... - Pittsburgh Tribune-Review,

Bespak shares rise almost 7 per cent on good returns  Jan 26, 2006
The FDA has also outlawed aerosol albuterol formulations containing CFC with effect from December 31, 2008, providing further opportunities for Bespak as ... - Business Weekly,

The Heroes Of 9/11 Are Getting Sick  Jan 29, 2006
So, he said, "they juiced us up with all kinds of Albuterol and various medications to keep us breathing." This allowed rescue workers to continue working on ... - Gotham Gazette,

TEENS ASK US: What could sinus pain and dizziness mean?  Jan 30, 2006
...also called "hayfever"). You also mentioned that you use albuterol for mild asthma that may contribute to such symptoms. If you ... - Grand Forks Herald,

Asthma Inhalers With CFC Propellants Could Be Banned  Jan 27, 2006
In March 2005, the FDA said inhalers using CFCs to dispense the prescription drug albuterol would be banned at the end of 2008. ... - Environment News Service

Mapleton toddler dies of RSV  Jan 28, 2006
Children diagnosed with RSV are often given the drug Albuterol. "It basically decreases your 'worker breathing' by expanding your lungs," Brenner said. ... - Sioux City Journal,

Inhaled Steroid Controls Asthma Better Than Oral Agent  Jan 12, 2006
Participants were 144 children ages six to 17 years with mild-to- moderate persistent asthma who used only as-needed bronchodilators (eg, albuterol). ... - CNN

Notes: Steelers will have to deal with thin air and cut-blocking  Jan 18, 2006
Jerome Bettis will feel it because of his asthma. He'll take his albuterol treatment during the middle of the week instead of just before the game. ... - Uniontown Herald Standard,

New Hope for CF Patients  Jan 18, 2006
She uses a nebulizer twice a day to inhale albuterol and hypertonic saline, a salt-water solution turned into a mist designed to help clear her lungs. ... - abc11tv.com,

Notebook: No complaints about cut-blocking  Jan 18, 2006
...of his asthma. He’ll take his albuterol treatment during the middle of the week instead of just before the game. Troy Polamalu ... - SteelCitySports.com

Good Counsel: When to worry about a cough  Jan 19, 2006
...clogged. They should use bronchodilators such as albuterol products as soon as they start coughing, whether they are wheezing or not. - Rochester Democrat and Chronicle,

Bronchiolitis a fact of life  Jan 8, 2006
The things we do for asthmatics don't help, either. Bronchodilators, such as albuterol, and corticosteroids, such as prednisone, aren't effective. ... - Milwaukee Journal Sentinel (subscription),

Lung patients are suffering from smoke, particles in air  Jan 16, 2006
Some people with asthma may need to increase the amount of "rescue medications," such as Albuterol inhalers, they use, and others will have to see their ... - Tulsa World (subscription),

Health: Waiting to inhale  Jan 7, 2006
...morning? * During the past four weeks, how often have you used your rescue inhaler or nebuliser medication (such as albuterol)? ... - Malay Mail, Merck KGaA Names Engle New Generics Group Regional Director, North ...  Jan 4, 2006
PR Newswire (press release), The Web sites for DEY include http://www.dey.com, http://www.accuneb.com, http://www.curosurf.com, http://www.duoneb.com, http://www.epipen.com. ...

Some asthmatics may lose their inhalers  16 Jan 2006
CNN/Money Albuterol is available in prescription inhalers that use HFA, including GlaxoSmithKline's (up $0.23 to $51.60, Research) Ventolin, and Proventil from the ...

Health News  Dec 20, 2005
Hampton Union, ...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ...

Tests show Salamol asthma inhaler safe, effective  Jan 5, 2006
New Zealand Herald, Independent tests have confirmed the Salamol brand of salbutamol asthma inhaler is safe and effective, says the Government drug-buying agency Pharmac. ...

SALAMOL ASTHMA INHALER SAFE AND EFFECTIVE, SAYS PHARMAC  Jan 4, 2006
TMCnet Zealand Press Association Via Thomson Dialog NewsEdge)Wellington, Jan 5 NZPA - Independent tests have confirmed the Salamol brand of salbutamol asthma inhaler ...

Ban drama motivated Josephs  Jan 9, 2006
News24, 22. Josephs was suspended in December last year for six months after he tested positive for the second time for using salbutamol. ...

Substitute inhalers pass test  Jan 5, 2006
Stuff.co.nz, 2005. It said the sole-supply deal for Salamol – like Ventolin, a salbutamol inhaler – would save $1.7 million over 18 months. ...

Full effects of new asthma inhaler not known, says group  Jan 5, 2006
Stuff.co.nz, More research should be done on the effects of the Salamol brand of salbutamol asthma inhaler on children, pregnant women and other vulnerable patients, says ...

Josephs' form what the doctor ordered for Ajax  Dec 22, 2005
Cape Argus (subscription), Josephs was three weeks ago slapped with a six-month ban after testing positive for the second time in 12 months for the banned substance salbutamol. ...

Children at risk from asthma treatment, says Asthma NZ  Jan 5, 2006
Stuff.co.nz, ...vindication of its decision, later changed, to replace the popular ventolin with salamol as the country's sole Government-subsidised salbutamol asthma inhaler ...

Ventolin still in top spot  Jan 8, 2006
Stuff.co.nz, To save money, the government drug-buying agency Pharmac last year began subsidising Salamol in place of long-standing salbutamol inhaler Ventolin. ...

Release of Fourth Quarter Activity Report  Jan 8, 2006
Scoop.co.nz (press release), Easier After Samasol Report - A report by Government medicines assessment agency Medsafe has confirmed that the Salamol brand of salbutamol asthma inhalers is ...

Sison: Bill expands grounds for legal separation  Jan 3, 2006
Sun.Star, ...the cardiac drug Adalat Retard 20mg tab (Nifedipine); the liprotropic Lopid 3200mg cap; the sympathomimetic drug Ventolin 100mcg/200do (Salbutamol); and the ...

Some asthmatics may lose their inhalers  16 Jan 2006
CNN/Money Albuterol is available in prescription inhalers that use HFA, including GlaxoSmithKline's (up $0.23 to $51.60, Research) Ventolin, and Proventil from the ...

Ventolin still in top spot  Jan 8, 2006
Stuff.co.nz, Seven out of 10 asthmatics are choosing to pay more to stick with the reliever inhaler Ventolin, rather than opting for its cheaper replacement, figures show. ...

Tests show Salamol asthma inhaler safe, effective  Jan 5, 2006
New Zealand Herald, The agency sees the findings announced yesterday as vindication of its decision, later changed, to replace the popular Ventolin with Salamol as the country's ...

Substitute inhalers pass test  Jan 5, 2006
Stuff.co.nz, Salamol hit the New Zealand market in February last year after Government drug-buying agency Pharmac announced its subsidies for Ventolin inhalers would end in ...

Full effects of new asthma inhaler not known, says group  Jan 5, 2006
Stuff.co.nz, ...agency, Pharmac, is claiming the findings, announced yesterday, as vindication of its decision, later changed, to replace the popular Ventolin with Salamol as ...

Pharmac 'vindicated' by asthma inhaler report  Jan 5, 2006
Radio New Zealand, Some asthma sufferers reported it had an unpleasant alcohol taste, that it tended to block up and was not as effective as Ventolin. ...

Salamol shown to be effective  Jan 4, 2006
Newstalk ZB, There was public outcry last year when the drug funding agency announced it would fully subsidise Salamol instead of the more common medication Ventolin. ...

Children at risk from asthma treatment, says Asthma NZ  Jan 5, 2006
Stuff.co.nz, The Government drug-buying agency Pharmac is claiming the findings as vindication of its decision, later changed, to replace the popular ventolin with salamol ...

Fire victim always giving  Jan 2, 2006
Melbourne Herald Sun, Mike Rozier collapsed at Woy Woy Hospital after going there to seek Ventolin supplies for evacuees suffering breathing problems brought on by the bushfire smoke ...

PHARMAC praised  Jan 5, 2006
NZ City, The drug-funding agency commissioned a study into the medication after claims it is not as effective as Ventolin and concerns about its alcohol content. ...

Bushfire volunteer laid to rest  Jan 10, 2006
Advertiser Adelaide, St Johns Ambulance volunteer Mike Rozier, 64, collapsed at Woy Woy Hospital while collecting Ventolin and other medical supplies for bushfire evacuees on ...

Salamol brand of asthma inhaler OK: Medsafe  Jan 4, 2006
Radio New Zealand, Government funding agency Pharmac says the report reinforces its initial view that Salamol inhalers are just as safe and effective as ventolin ones. ...

Hundreds farewell St John volunteer  Jan 10, 2006
Seven.com.au, Mike Rozier collapsed and died at Woy Woy Hospital while getting Ventolin and other medical supplies for the Ettalong bushfire evacuation centre. ...

Ambulance guard in silent tribute  Jan 11, 2006
Wodonga Border Mail, ...bushfires. Mike Rozier collapsed and died at Woy Woy hospital while getting Ventolin and other supplies for an evacuation centre. ...

Sison: Bill expands grounds for legal separation  Jan 3, 2006
Sun.Star, ...name is cotrimoxazole; the cardiac drug Adalat Retard 20mg tab (Nifedipine); the liprotropic Lopid 3200mg cap; the sympathomimetic drug Ventolin 100mcg/200do ...

Food can kill allergic kids, parents warn  Jan 9, 2006
Brockville Recorder and Times, They gave her ventolin to help with the breathing, but this reaction required the EpiPen, a painful injection that Reese still recalls with dread. ...

Into the Blue Box  Dec 20, 2005
Minda News, And so, armed with a mug of coffee and Ventolin inhaler, I embarked on my little archeological expedition in the Cotabato office. I started with the drawers. ...

Nostalgia for nausea and a tie-dyed season of teenage lust  Dec 29, 2005
Australian, ...epidermis of dust, which means that by the time I dig Andrew's photographs from the palimpsest of my past, I'm wheezing and require a hearty snort of Ventolin. ...

Cooler weather aids bushfires fight  Jan 1, 2006
TVNZ, Mike Rozier, 64, suffered an apparent heart attack after going to Woy Woy Hospital to get supplies of Ventolin for people suffering breathing problems caused ...

NSW races to control fires  Jan 2, 2006
NEWS.com.au, ...attack. He died after going to Woy Woy Hospital to seek Ventolin supplies for evacuees suffering breathing problems from the smoke. ...

Fire volunteer dies  Jan 1, 2006
Melbourne Herald Sun, Mr Rozier went to the hospital about 9pm (AEDT) yesterday to get supplies of Ventolin for people suffering breathing problems as a result of the bushfires. ...

Dedicated to life's duty  Jan 2, 2006
Daily Telegraph, ...looked ill. Mr Rozier was collecting Ventolin units to assist the breathing of bushfire victims suffering smoke inhalation. A minute ...

Wednesday funeral for St John volunteer  Jan 4, 2006
Sydney Morning Herald, Mike Rozier collapsed at Woy Woy Hospital on Monday after going there to seek Ventolin supplies for evacuees suffering breathing problems brought on by ...

Bushfires feed on record temperatures  Jan 2, 2006
ABC Online, TONY FORREST, FRIEND AND COLLEAGUE, ST JOHN AMBULANCE: Mike went down to Woy Woy Hospital to get some ventolin for some of the evacuees. ...

Defence may relax entry standards  Dec 22, 2005
Ninemsn, ...manage it. There's not much point being out on a long-range reconnaissance patrol and running out of ventolin," he said. "Obesity ...

Fat, unfit not out of running  Dec 23, 2005
Wodonga Border Mail, ...able to manage it. Theres not much point being out on a long-range reconnaissance patrol and running out of Ventolin,� he said.

Ventolin still in top spot  Jan 8, 2006
Stuff.co.nz, Eyre said. His Ventolin inhaler would normally have cleared up a similar attack in half a day. "I don't care what they say. As far ...

Into the Blue Box  Dec 20, 2005
Minda News, And so, armed with a mug of coffee and Ventolin inhaler, I embarked on my little archeological expedition in the Cotabato office. I started with the drawers. ...

Obey will be missed  Jan 5, 2006
Austin American-Statesman (subscription), It hasn't been long since this community buried Volma Overton, the notable Austin NAACP president who helped desegregate Austin schools and businesses. ...

It’s all in the name  Dec 28, 2005
Calcutta Telegraph, A 50-year-old woman, for example, was hospitalised after taking Flomax, used to treat the symptoms of an enlarged prostate, instead of Volmax, used to relieve ...

Sepracor to defend Xopenex  Jan 12, 2006
MetroWest Daily News, ...said yesterday that it will defend its patent rights following a challenge from Dey LP over a generic version of the Xopenex asthma treatment. ...

Pharmacist wages war on drug costs  Jan 14, 2006
Evansville Courier & Press (subscription), ...see Melinda Klein. Three published studies touted the benefits of Xopenex for asthma patients requiring emergency care. But Klein ...

Sepracor Snoozes  Jan 13, 2006
Smartmoney.com ...months, but that could change. Sepracor recently added a portable inhaler to its Xopenex asthma treatment. And while the sleep market ...

Sepracor Receives Notice of Second Abbreviated New Drug ...  Jan 12, 2006
Business Wire (press release), Dey's submission includes a Paragraph IV certification alleging that Sepracor's patents listed in the Orange Book for XOPENEX(R) inhalation solution are invalid ...

Sepracor Receives Notice of Second Abbreviated New Drug ...  Jan 12, 2006
Finanzen.net, ...solution.Dey's submission includes a Paragraph IV certification alleging thatSepracor's patents listed in the Orange Book for XOPENEX(R) inhalationsolution are ...

Kansas firm wins $1.1b Air Force-Navy plane pact  Jan 13, 2006
Boston Globe, Sepracor Inc.'s patents on the asthma drug Xopenex are being challenged by Dey LP, which filed an abbreviated new-drug application for its version of the ...


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