Adenosine resources


DRUG INFO
Adenosine

Drug Name: Adenosine

Indication: For the conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome)



Pharmacology: Adenosine is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Adenosine is indicated for the conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome). Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of nucleoside transport such as dipyridamole. Adenosine is not blocked by atropine.

Mechanism Of Action: Adenosine slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome.

Drug Category: Vasodilator Agents; Antiarrhythmic Agents; Analgesics; Cardiac drugs; ATC:C01EB10

Brand Names/Synonyms: 2'-Deoxyadenosine; Adenine Deoxy Nucleoside; Adenine Deoxyribonucleoside; Adenine Deoxyribose; Adenine Nucleoside; Adenine Riboside; Adenocard; Adenocor; Adenoscan; Adenosin; Adenosine; Adenosine 99%; Adenosine for Biochemistry; Adenosine, Free Base; Adensoine; Adenyldeoxyriboside; Boniton; CCRIS 1782; Da; Deoxyadenosine; Desoxyadenosine; Myocol; Nucleocardyl; Sandesin; Usaf Cb-10

Dosage Forms: LIQUID

Absorption: Not Available

Interactions: DrugBank: Interactions for Adenosine

Interactions for Adenosine:


Intravenous Adenocard (adenosine) has been effectively administered in the presence of other cardioactive drugs, such as quinidine, beta-adrenergic blocking agents, calcium channel blocking agents, and angiotensin converting enzyme inhibitors, without any change in the adverse reaction profile. Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenocard. Because of the potential for additive or synergistic depressant effects on the SA and AV nodes, however, Adenocard should be used with caution in the presence of these agents. The use of Adenocard in patients receiving digitalis may be rarely associated with ventricular fibrillation.

The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline. In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective. Adenosine effects are potentiated by dipyridamole. Thus, smaller doses of adenosine may be effective in the presence of dipyridamole. Carbamazepine has been reported to increase the degree of heart block produced by other agents. As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine.





Chemical IUPAC Name: 2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Chemical Formula: C10H13N5O4

Half Life: <10 secs

Drug Type: Approved Drug

# Accession No: APRD00132

CAS Registry Number: 58-61-7



Adenosine News
(When available)



A New Way of Looking at Molecular Motors  09 Feb 2006
Molecular motors run on tracks, like trains, using chemical reactions that involve the chemical compound adenosine triphosphate (ATP) for fuel. ... - AScribe

An Unlikely Role For The Cystic Fibrosis Gene In The Kidney  09 Feb 2006
The ROMK channels from Cftr-deficient mice also demonstrated an impaired response to a small energy molecule called ATP (adenosine triphosphate). ... - Medical News Today (press release),

CORvalenTM (D-Ribose) Improves Pain And Quality Of Life In ...  09 Feb 2006
...“We do know however that people with fibromyalgia have lower levels of the energy molecule called adenosine triphosphate (ATP) and a reduced capacity to make ... - Medical News Today (press release),

Pharmacopeia Receives Milestone Payment Following Delivery of ...  Feb 8, 2006
CCR-1 antagonists (anti-inflammatory agents with therapeutic potential in rheumatoid arthritis and multiple sclerosis) and adenosine A2A antagonists (anti ... - PR Newswire (press release),

ST. LOUIS POST-DISPATCH  Feb 5, 2006
That's because a powerful chemical called adenosine triphosphate, or ATP, is providing fuel for the muscles. But ATP lasts only about 15 seconds. ... - St. Louis Post-Dispatch,

Can-Fite BioPharma Appointed Dr. Ilan Cohn as Vice Chairman of the ...  Feb 7, 2006
...a multi-layered intellectual property platform that positions the company as a leader in the therapeutic field of drugs that target the A3 adenosine receptor. ... - Genetic Engineering News,

Cardiac Emergency  Feb 6, 2006
CoQ10 is also known for its role in mitochondrial ATP (adenosine triphosphate) synthesis, a crucial aspect of energy production on a cellular level. ... - Natural Products Industry Insider,

Weekly Calendar  Feb 6, 2006
Tues., Feb. 7, 4:15 pm "The Chemistry of RNA Editing by Adenosine Deaminases," a Chemistry colloquium with Peter Beal, University of Utah; 233 Remsen. HW. ... - Johns Hopkins Gazette,

Darkness Unveils Vital Metabolic Fuel Switch Between Sugar And Fat  Jan 25, 2006
A series of experiments pinpointed 5-prime adenosine monophosphate (5'-AMP) as the key molecular mediator of the constant darkness effect, switching mice from ... - Science Daily (press release)

High-buzz drinks attract teens looking for energy  Jan 29, 2006
BY HANNAH GOULD. Chemically known as trimethylxanthine, caffeine blocks the brain's receptors of adenosine. Adenosine is a chemical ... - Detroit Free Press,

Anesthetic preconditioning as the alternative to ischemic ...  Jan 23, 2006
We read with interest the article by Canyon and Dobson 1 presenting a combination of the adenosine A1 agonist 2-chloro-N6-cyclopentyladenosine (CCPA) and ... - The Journal of Thoracic and Cardiovascular Surgery

UVa wants science to lure businesses  Jan 28, 2006
...and easier for the university and the state to create more products," said Joel Linden, a professor of medicine and co-founder of Adenosine Therapeutics, a ... - Charlottesville Daily Progress,

High throughput screening for kinase inhibitors  Feb 3, 2006
...for kinase inhibition. Kinases phosphorylate proteins with the terminal phosphate of adenosine triphosphate (ATP). The Liverpool ... - RSC,

Department of Physiology and Pharmacology, James Cook University ...  Jan 23, 2006
On the other hand, we reported that pretreating the heart with an intravenous solution of the adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine ... - The Journal of Thoracic and Cardiovascular Surgery

TICKLED THINK!  Jan 19, 2006
Normally, we feel sleepy because the brain produces a substance called adenosine, which binds itself to nerve cells and slows them down, making us drowsy. ... - Glasgow Daily Record,

New Treatments For Diabetic Kidney Disease  Jan 9, 2006
..."These drugs act on receptors for the compound adenosine. We've been working with drugs affecting the adenosine system in acute ... - Medical News Today (press release),

Standard Test May Miss Heart Disease in Women  Feb 1, 2006
A better test is the so-called provocative coronary testing, a stress test in which an adenosine injection mimics the effects of exercising on a treadmill. ... - Los Angeles Times,

New findings about messenger molecule raise hopes for new drugs  Jan 19, 2006
University scientists have developed a new method for measuring the concentration of the messenger substance for cells, cyclic adenosine monophosphate (cAMP ... - Innovations-Report,

Duska Therapeutics Announces Board Change  Jan 26, 2006
...is an emerging biopharmaceutical company that is focusing on the development of diagnostic and therapeutic products related to adenosine 5'-triphosphate, or ATP ... - Genetic Engineering News,

More Nashvillians perk up for Caffeine  Jan 31, 2006
...is sleep-deprived. Caffeine works by blocking the action of adenosine, a brain chemical that promotes sleep. Caffeine's role in ... - Robertson County Times,

Fresh from the Pipeline: Nelarabine  Jan 9, 2006
Nelarabine (Fig. 1) is demethoxylated by adenosine deaminase to ara-G, and converted by cellular kinases to the active 5'-triphosphate, ara-GTP. ... - Nature.com (subscription),

Can-Fite in R&D pact with NIH  Jan 24, 2006
The agreement relates to new small molecules that are agonists of the A(3) adenosine receptor A(3)AR, invented in the laboratory of Prof. ... - Jerusalem Post,

Hibernation gene could be medical eye opener  Jan 18, 2006
Subsequently, they found elevated levels of a small molecular compound, Adenosine monophosphate, or AMP, in the blood of mice exposed to constant darkness. ... - Houston Chronicle,

Coffee limits blood flow to heart  Jan 15, 2006
Dr. Kaufmann said that caffeine may block certain receptors in the walls of blood vessels, interfering with the normal process by which adenosine signals blood ... - Newindpress,

Sulfonylureas for Type 2 Diabetes Drugs Linked to Heart Deaths  Jan 17, 2006
Sulfonylureas promote insulin release by binding to adenosine triphosphate (ATP)-sensitive potassium channels in pancreatic cells, thereby keeping these ... - CNN

Pharmacopeia's Delivery of Additional Lead Compounds to Organon ...  Jan 11, 2006
...immunosuppressant with potential utility in multiple indications including psoriasis, multiple sclerosis and transplant rejection), adenosine A2A antagonists ... - Yahoo! News (press release)

New malaria treatment guidelines issued  Jan 20, 2006
Artemisinin and its derivatives inhibit an essential calcium adenosine triphosphatase, PfATPase 6. Artemisinin has now given way to the more potent ... - Pan American Health Organization,

Baby continues to battle near-fatal health problems 4-month-old ...  Jan 22, 2006
We really didn't understand the enormity of the situation.". Doctors administered a drug called adenosine seven times but it failed to slow his heartbeat. ... - Waterbury Republican American,

In Good Shape  Jan 23, 2006
The natural compound staurosporine is an effective inhibitor for the adenosine triphosphate (ATP) dependent protein kinases because it fits precisely into the ... - Innovations-Report,

Can-Fite BioPharma Signed a Cooperative Research and Development ...  Jan 24, 2006
Agreement (CRADA) with the National Institute of Health in the US The CRADA relates to new small molecules that are agonists of the A(3) adenosine receptor (A(3 ... - Genetic Engineering News,

Leaf Carbohydrate Metabolism Enzymes: Are They Up- or Down ...  Jan 24, 2006
...of the key enzymes involved in carbon utilization or the synthesis of sucrose and starch: sucrose-phosphate synthase (SPS) and adenosine-5'-diphosphoglucose ... - CO2 Science Magazine,

Study supports ForsLean efficacy, safety  Jan 11, 2006
Amongst other effects, this is understood to increase lean body mass and help optimize body composition though cAMP (cyclic adenosine monophosphate) activation ... - NutraIngredients.com,

Division of Thoracic and Cardiovascular Surgery, Ribeirão Preto ...  Jan 23, 2006
This blockage also enhances the "crosstalk" between cyclic adenosine monophosphate (cAMP) and cGMP pathways, which facilitates the effect of the cAMP-dependent ... - The Journal of Thoracic and Cardiovascular Surgery

Cocaine in Coca-Cola  Jan 21, 2006
...the next morning. This is because caffeine blocks adenosine, a chemical in the brain that causes drowsiness. Caffeine also gives ... - Paly Voice, Williams-Labadie Promotes Jim Grossmann to Senior Vice President ...  Jan 13, 2006
PharmaLive.com (press release), During that time, he has directed a wide range of innovative marketing programs to support the growth of Adenoscan® -- the largest brand in the Astellas ...


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