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Adalimumab
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DRUG INFO
Adalimumab
Drug Name:
Adalimumab
Indication: For treatment of rheumatoid arthritis
Pharmacology: Used in the treatment of rheumatoid arthritis. Elevated levels of TNF are found in the synovial fluid of rheumatoid arthritis patients and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of the disease. Adalimumab binds specifically to TNF-alpha and blocks its general cytokine effects, thereby reducing TNF-induced inflammation and halting the joint destruction.
Mechanism Of Action: Adalimumab binds to TNF-alpha and blocks its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface TNF expressing cells in vitro in the presence of complement.
Drug Category: Immunomodulatory Agents; Antirheumatic Agents; unclassified therapeutic agents (92:00.00)
Brand Names/Synonyms: Ig gamma-1 chain C region; Humira (Abbott Laboratories)
Dosage Forms: Solution
Absorption: Not Available
Interactions: Not Available
Chemical IUPAC Name: Humanized anti-TNF antibody (D2E7)
Chemical Formula: C6428H9912N1694O1987S46 >Mouse-Human chimeric chain 1 Anti-TNF alpha VL >Mouse-Human chimeric chain 2 Anti-TNF alpha VH >Mouse-Human chimeric chain 2 Anti-TNF alpha VL
Half Life: 10-20 days.
Drug Type: Approved Drug
# Accession No: BIOD00049
CAS Registry Number: 331731-18-1
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Adalimumab News
(When available)
Combination Better Than Monotherapy for Early Aggressive Arthritis 05 Jan 2006
MedPage Today, ...with aggressive combination therapy and establishes the superiority of combination therapy to either methotrexate monotherapy or adalimumab monotherapy,� the ...
US okay for B-MS' blockbuster candidate Jan 2, 2006
Pharma Times (subscription), ...anti-tumor necrosis factor products such as Johnson & Johnson's Remicade (infliximab), Wyeth's Enbrel (etanercept) and Abbott Laboratories' Humira (adalimumab ...
Two drugs better than one for RA: study Dec 30, 2005
Reuters.uk, NEW YORK (Reuters Health) - For adults with early, aggressive rheumatoid arthritis (RA), treatment with a combination of Humira (adalimumab) and methotrexate ...
New Drugs Offer More Choices for Psoriasis Dec 21, 2005
Spartanburg Herald Journal (subscription), ...psoriatic arthritis or psoriasis include Remicade; alefacept, sold as Amevive; etanercept, sold as Enbrel; efalizumab, sold as Raptiva; and adalimumab, sold as ...
New Year, new drug for arthritis patients Dec 4, 2005
Scoop.co.nz (press release), The new generation arthritis treatment adalimumab (Humira), one of the TNF alpha inhibitor drugs, will be fully funded for people with severe rheumatoid ...
Arthritis medicine to be fully funded Dec 4, 2005
Stuff.co.nz, The new generation arthritis treatment adalimumab (Humira), one of the TNF alpha inhibitor drugs, will be fully funded from January 1. ...
Long protest brings arthritis relief Dec 6, 2005
Stuff.co.nz, Devoted dad Richard Crowe spent months protesting after discovering a subsidised drug – TNF alpha inhibitor drug adalimumab (Humira) – which helped his ...
Juvenile Arthritis - A Niche In The Market Dec 20, 2005
Pharmaceutical Business Review Juvenile arthritis is the next indication due for approval for blockbuster biologic therapies Remicade (infliximab) and Humira (adalimumab). ...
Arthritis hope on horizon Dec 4, 2005
Newstalk ZB, PHARMAC is funding the new generation arthritis treatment adalimumab from January 1st 2006. It will spend $35 million on the treatment over five years. ...
Back pain relief may be within your reach 16 Jan 2006
Daytona Beach News-Journal, In the past few years, due to a scientific breakthrough, several biologic agents known as "anti-tumor necrosis agents" such as Humira, Enbrel and Remicade have ...
Humira And Methotrexate In Combination Better Than Either Drug ... Jan 1, 2006
About - News & Issues, ...the January 2006 issue of Arthritis and Rheumatism, reveal that for adults with early, aggressive rheumatoid arthritis treatment with Humira and methotrexate ...
Study boosts Humira Dec 30, 2005
Chicago Tribune, Abbott Laboratories' Humira is effective as a first treatment for patients with aggressive rheumatoid arthritis, according to a company-funded study in the ...
New treatments for rheumatoid arthritis Jan 14, 2006
Packet Online, ...new advances in RA treatment involve a new group of anti-inflammatory medications called biologic response modifiers, including Enbrel, Humira, Kineret and ...
Pharmac to spend $103 million more on NZers Jan 8, 2006
Stuff.co.nz, ...asthma. The largest funding decision this year made the rheumatoid arthritis drug adalimumab (Humira) available to New Zealanders. ...
PHARMAC invests $103 million in NZers’ health Jan 8, 2006
Scoop.co.nz (press release), ...diabetes. The largest single funding decision made this year has involved the rheumatoid arthritis drug adalimumab (Humira). The ...
Combination Better Than Monotherapy for Early Aggressive Arthritis Jan 5, 2006
MedPage Today, 5 - Combination therapy with Humira (adalimubab) and methotrexate is better for treating early aggressive rheumatoid arthritis than is either drug alone ...
Two drugs better than one for RA: study Dec 30, 2005
Reuters.uk, NEW YORK (Reuters Health) - For adults with early, aggressive rheumatoid arthritis (RA), treatment with a combination of Humira (adalimumab) and methotrexate ...
UCB initiated with "neutral" Jan 4, 2006
New Ratings The competitve landscape in the Crohn's disease market is challenging, in view of the sBLA filing of Humira, which is expected to be submitted after 12 months ...
Business briefs Dec 30, 2005
Worcester Telegram (subscription), ABBOTT PARK, Ill. — Early-stage rheumatoid arthritis patients who took the drugs Humira and methotrexate together were more likely to go into remission or ...
Bristol-Myers gets FDA approval for arthritis drug Dec 24, 2005
Economic Times, ...therapies. Older treatments include Abbott Laboratories Inc's Humira, Johnson & Johnson's Remicade and Amgen Inc's Enbrel. Three ...
Abbott to win big if Boston buys Guidant Jan 10, 2006
Boston Globe, ...would be the company's second-largest, behind its $6.9 billion acquisition of Knoll Pharmaceuticals, a deal that brought with it Humira, Abbott's blockbuster ...
Commercial Insight: Disease Modification in Rheumatoid Arthritis ... Dec 20, 2005
Pharmaceutical Business Review The launch of new treatments at a premium cost appears to confer a superior treatment, as exemplified by Abbott's launch of Humira. ...
Fitch: Abbott Laboratories' Ratings Unchanged After Acquisition ... Jan 9, 2006
Business Wire (press release), 30, 2005, supported by attractive growth of Humira, offset by generic competition for Synthroid and the immediate-release formulation of Biaxin.
FDA OKs Bristol-Myers rheumatoid arthritis drug Dec 23, 2005
Herald News Daily, ...one or more other therapies. Older tre - ) Humira, Johnson & Johnson‘s (NYSE: - ) Remic - ) Enbrel. Three Bristol-Myers studies ...
Biologic drugs the latest psoriasis weapon Dec 20, 2005
United Press International It as well as Amevive, Enbrel, Humira and Raptiva have been approved to treat psoriasis and psoriatic arthritis since 2003, the newspaper reported. ...
Juvenile Arthritis - A Niche In The Market Dec 20, 2005
Pharmaceutical Business Review Juvenile arthritis is the next indication due for approval for blockbuster biologic therapies Remicade (infliximab) and Humira (adalimumab). ...
Medicare expands tier pricing system Jan 3, 2006
USA Today Patients would pay more, for example, if they sought the expensive rheumatoid arthritis treatments Humira or Enbrel for a less serious use, such as for the ...
Fitch Affirms Abbott Laboratories 'AA-'; Outlook Stable Dec 22, 2005
Business Wire (press release), ...growth drivers, including high-volume diagnostic instrumentation, including the Prism and Cell-Dyn Sapphire, and two new indications for Humira, first-line ...
Charity demands arthitis therapy Jan 2, 2006
Norfolk Eastern Daily Press, In 2004, she was treated with Humira, one of the anti-TNF therapies, and the change was dramatic: within a few weeks she was cutting down trees, trimming ...
Recent Advances in Biologic Therapies Jan 6, 2006
Medscape (subscription) Long-term efficacy, remission, and safety of adalimumab (HUMIRA) plus methotrexate in patients with rheumatoid arthritis in the ARMADA trial. ...
Four for safety, three for thrills Jan 1, 2006
This is Money, ...pharmaceutical companies. Its most important source of revenue is Humira, an arthritis treatment on which CAT receives royalties. The ...
US okay for B-MS' blockbuster candidate Jan 2, 2006
Pharma Times (subscription), ...anti-tumor necrosis factor products such as Johnson & Johnson's Remicade (infliximab), Wyeth's Enbrel (etanercept) and Abbott Laboratories' Humira (adalimumab ...
New Drugs Offer More Choices for Psoriasis Dec 21, 2005
Spartanburg Herald Journal (subscription), ...arthritis or psoriasis include Remicade; alefacept, sold as Amevive; etanercept, sold as Enbrel; efalizumab, sold as Raptiva; and adalimumab, sold as Humira. ...
Bristol-Myers Shares Gain in Europe After US Clears Drug Dec 27, 2005
Bloomberg Existing treatments for rheumatoid arthritis include Enbrel, sold by Amgen Inc. and Wyeth, Johnson & Johnson's Remicade and Abbott Laboratories' Humira. ...
Bristol-Myers Squibb Receives US Approval for Arthritis Drug Dec 23, 2005
New York Times, ...status. Orencia will compete with Enbrel by Amgen, Remicade by Johnson & Johnson and Humira by Abbott - all called anti-TNF agents. ...
Pharmac relents on Zoladex Dec 19, 2005
National Business Review, ...cent, AstraZeneca said, but Abbott would get substitute subsidies in the form of funding for "Abbott Laboratories’ rheumatoid arthritis drug Humira, and to ...
Judge triples jury's penalty for Stratagene Dec 20, 2005
San Diego Union Tribune, 26 settlement that it and several other companies reached in connection with a case involving the sales of Abbott's Humira product for the treatment of ...
Cancer medicine to be withdrawn due to subsidy cut Dec 14, 2005
Scoop.co.nz (press release), In exchange, PHARMAC is to fund Abbott Laboratories’ rheumatoid arthritis drug Humira, and to guarantee security of supply for Lucrin at the reduced price ...
Eisai Submits New Drug Application for Rheumatoid Arthritis Drug ... Dec 26, 2005
Japan Corporate News (press release), ...active rheumatoid arthritis. Abbott markets adalimumab (D2E7) in the US and European Union under the brand name of HUMIRA. In Japan ...
Eisai Submits New Drug Application for Rheumatoid Arthritis Drug ... Dec 27, 2005
Chemie.de (press release), ...severely active rheumatoid arthritis. Abbott markets adalimumab (D2E7) in the US and European Union under the brand name of HUMIRA(R).
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