Acyclovir resources


DRUG INFO
Acyclovir

Drug Name: Acyclovir

Indication: For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox



Pharmacology: Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.

Mechanism Of Action: Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts acyclovir to the acyclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Acyclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, acyclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.

Drug Category: Antivirals; Nucleosides and Nucleotides (08:18.32); ATC:J05AB

Brand Names/Synonyms: AC2; Aciclovier; Aciclovir; Acycloguanosine; Acyclovir; Acyclovir Sodium; Alti-Acyclovir; Avirax; BW-248U; Valtrex; Vipral; Virorax; Wellcome-248u; Zovirax; Zovirax Wellstat Pac; Zovirax Zostab Pac

Dosage Forms: Intravenous Infusion; Capsules; Tablets; Suspension; Topical Cream; Topical Ointment

Absorption: Oral _ Bioavailability 10 to 20%

Interactions: Co-administration of probenecid with acyclovir has been shown to increase the mean half-life and the area under the concentration-time curve. Urinary excretion and renal clearance were correspondingly reduced. The clinical effects of this combination have not been studied.



Chemical IUPAC Name: 2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one

Chemical Formula: C8H11N5O3

Half Life: 2.5-3.3 hours

Drug Type: Approved Drug

# Accession No: APRD00567

CAS Registry Number: 59277-89-3



Acyclovir News
(When available)



'Kissing disease' responds to newer form of old drug  Jan 12, 2006
Studies of the herpes drug acyclovir in the 1980s and 1990s failed to show a benefit in people with mono, but Dr. Henry Balfour, a herpes specialist at the ... - Macleans,

INFECTION PLAYS MAJOR ROLE IN ULCERS  Jan 24, 2006
...to come down with encephalitis. Acyclovir is a medicine that can be used for herpes encephalitis. Your aunt's course might have ... - Charlotte Sun-Herald,

Second horse with equine herpesvirus euthanized at Pimlico  Jan 13, 2006
The horses in the detention barn that have tested positive are being treated with anti-pyretic drugs, steroids and Acyclovir, a human anti-viral used in the ... - Thoroughbred Times,

Pimlico illness strikes again  Jan 14, 2006
He also said the horses are being treated with acyclovir, an oral, anti-viral medication for humans, because it is the only medication available to lessen the ... - Baltimore Sun,

Equine herpes virus appears to be more common, severe  Jan 15, 2006
In the past two years, some veterinarians have tried acyclovir, a human antiviral medicine, which seems to help some stricken animals. ... - Baltimore Sun,

BioAlliance Pharma Appoints Former GlaxoSmithKline Executive as ...  Jan 23, 2006
...indication. A second product, acyclovir Lauriad(R), for the treatment of oral herpes, has completed a Phase I clinical trial in Europe. ... - Genetic Engineering News,

It works for me: hot treatment for cold sores  Jan 20, 2006
...glands. The standard treatment is anti-viral cream such as acyclovir, which is also available in tablet form for more severe cases. ... - Times Online,

FLAVORx Enhances Treatment Options for Pediatric Oncology Patients  Jan 19, 2006
3. Acyclovir (to prevent viral infections)- Orange Cream, Banana, Cherry. 4. Septra/Bactrim (to prevent some types of pneumonia)- Grape, Bubblegum, Watermelon. ... - PR Web (press release), ICAAC: Women who shed HSV in genitals shed more HIV  Jan 8, 2006
Aidsmap, The study investigators suggest that providing the anti-HSV drug aciclovir to women with genital ulcerative disease may be a way of reducing the risk of HIV ...

Pharma cos may record modest growth in Q3  16 Jan 2006
TMCnet ...currently in litigation. The rulings for Actos, Valtrex, Fiomax, Provigil and Tricor are expected in the coming months. Dr Reddy's ...

Pharma cos may record modest growth in Q3  Jan 15, 2006
Economic Times, 7-8 are currently in litigation. The rulings for Actos, Valtrex, Fiomax, Provigil and Tricor are expected in the coming months.

'Kissing disease' responds to newer form of old drug  Jan 12, 2006
Macleans, ...of Minnesota, decided to take another look at the treatment, this time in the form of a related medication called valacyclovir (brand name Valtrex), which is ...

1/13 WWE Friday Night Smackdown Express: New champion, other new ...  Jan 14, 2006
Pro Wrestling Torch Piper said it looked like some sort of herpes, and said that they have Valtrex which can bring that down. JBL had to hold Jillian back. ...

Herpes virus can go into hiding  Dec 19, 2005
Charleston Post Courier (subscription), Several medications - acyclovir (Zovirax, generic), famciclovir (Famvir) and valacyclovir (Valtrex) - can shorten a herpes outbreak by a day or two. ...

Indian drug firms to continue with strategy  Dec 19, 2005
International Herald Tribune, Besides Lipitor, Ranbaxy is fighting more than a half-dozen cases challenging patents on brands like GlaxoSmithKline's herpes drug Valtrex; AstraZeneca's anti ...

Indian Drug Maker Says It Will Keep Attacking Patents Despite ...  Dec 19, 2005
New York Times, In addition to Lipitor, Ranbaxy is fighting more than a half-dozen cases challenging the patents on brands like Valtrex, GlaxoSmithKline's herpes drug; Nexium ...

Herpes virus can go into hiding  Dec 19, 2005
Charleston Post Courier (subscription), Several medications - acyclovir (Zovirax, generic), famciclovir (Famvir) and valacyclovir (Valtrex) - can shorten a herpes outbreak by a day or two. ...


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